Brenda Andrews

Brenda Andrews, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1308
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-8562

Web Site: http://sites.utoronto.ca/andrewslab/homepage.html


Research:

Studying simple yeast cells to understand human cells


Education:

Postdoctoral Fellow: University of California, San Francisco
Ph.D.: University of Toronto
B.Sc.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

Research Interests:

The Andrews lab uses functional genomics coupled with yeast genetics and cell biology to study cell cycle transcription factor pathways and mechanisms of cell cycle regulation. Current projects include: 1) systematic synthetic dosage lethality (SDL) screens using automated yeast genetics to define targets of protein kinases; 2) a 'phenomics' project that uses high through put fluorescence microscopy to define biological networks and to map cell cycle transcription factor pathways; 3) collaborations with the Boone, Hughes and other labs to map genetic networks controlling cell cycle progression and cell polarity in yeast.

 

Currently Accepting Graduate Students

Irene Andrulis

Irene Andrulis, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI, Room 984
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8256

Web Site: http://www.lunenfeld.ca/researchers/Andrulis


Research:

Genetic alterations in breast cancer and sarcoma


Education:

Postdoctoral Fellow:  University of Toronto
Ph.D.:  University of California, Irvine
B.Sc.:  University of Pennsylvania


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Medicine and Human Genetics

Research Interests:

My laboratory conducts multi-disciplinary studies to identify genetic alterations that play a role in breast cancer and sarcoma and to determine their clinical importance.  Our goals are to explore the biology of these genetic alterations, to aid in diagnosis and treatment, and to discover novel targets for therapeutics.


Not Accepting Graduate Students

Philip Awadalla

Philip Awadalla, Ph.D.

Professor

Address:
Ontario Institute for Cancer Research
MaRS Centre, Suite 6-42
661 University Ave.
Toronto, ON, M5G 0A3

Phone #: 647-260-7990

Web Site: http://pawadallalab.org

 


Research:

Organization and evolution of biological systems


Education:

Postdoctoral Fellow:  University of British Columbia and University of California, Davis
Ph.D.: University of Edinburgh
M.Sc.: University of Toronto


Fields of Interest:

  • Molecular Medicine and Human Genetics
  • Computational and Systems Biology

Research Interests:

Working with empirical genomic data and modern computational models, the laboratory addresses questions relevant to how genetics and the environment influences the frequency and severity of diseases in human populations. Our work focuses on next generation genomic tools to capture genetic determinants of phenotypes, specifically associated with aging, cancer and infectious diseases, from large population cohorts as well as family based studies.

 

Currently Accepting Graduate Students

Gary Bader

Gary Bader, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 602
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-3935

Web Site: http://baderlab.org/


Research:

Organization and evolution of biological systems


Education:

Postdoctoral Fellow:  Memorial Sloan-Kettering Cancer Center
Ph.D.: University of Toronto  
B.Sc.: McGill University


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

Research Interests:

We study the organization and evolution of biological systems using computational biology and bioinformatics techniques. This work is supported through the development of open-source biological pathway and network databases and visualization and analysis software.

 

Currently Accepting Graduate Students

Alan Bernstein

Alan Bernstein

Adjunct Professor

Address:
Canadian Institute for Advanced Research, Suite 1400
180 Dundas St.
Toronto, ON M5G 1X8

Phone #: 416-971-4255

Web Site: http://www.cifar.ca/cifar-staff


Research:

Intersection of research and public policy, especially science policy


Education

Postdoctoral Fellow:  Imperial Cancer Research Laboratories, U.K.
M.Sc, Ph.D.:  University of Toronto
B.Sc.:  University of Waterloo


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

Research Interests:

My current research interests centre around the intersection of research and public policy, especially with regard to science policy.

 

Not Accepting Graduate Students

Benjamin Blencowe

Benjamin Blencowe, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1016
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-3016

Web Site: http://sites.utoronto.ca/intron/


Research:

Regulation of gene expression and alternative splicing


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  EMBL, Heidelberg, Germany and University of London, UK
B.Sc (Hon):  Imperial College London, UK


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

Research Interests:

Our research focuses on mechanisms underlying the regulation of gene expression and how these mechanisms go awry in human diseases. Most of our research is directed at understanding how alternative splicing is integrated with other layers of gene regulation to control fundamental biological processes, such as cell fate determination.

 

Currently Accepting Graduate Students

Andrew Bognar

Andrew Bognar, Ph.D.

Associate Professor

Address:
University of Toronto
Medical Sciences Building, Room 4259
1 King's College Circle
Toronto, ON, M5S1A8

Phone #: 416-978-5854


Research:

Structure and functional of folylpolyglutamate synthetase


Education:

Postdoctoral Fellow:  Washington State University; Concordia University; John Hopkins University
Ph.D.:  McGill University
B.Sc. (Hon):  McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

Research Interests:

Structure and Function of folylpolyglutamate synthetase the enzyme that allows folate coenzymes and antifolate drugs to remain inside cells by forming polyglutamates. Studying the reaction mechanism by in vitro mutagenesis, kinetics and HPLC for product identification. Regulation of one-carbon metabolism in yeast by glycine. Role of antifolates in inflammatory diseases.

 

Not Accepting Graduate Students

Charles Boone

Charles Boone, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Room 1312
160 College Street
Toronto, ON M5S 3E1

Phone #: 416-946-7260

Web Site: http://sites.utoronto.ca/boonelab/


Research:

Functional genomics for mapping genetic, chemical-genetic, and protein-protein interactions in yeast


Education:

Postdoctoral Fellow:  University of Oregon
Ph.D.:  McGill University
B.Sc.:  Queen's University


Fields of Interest:

Computational and Systems Biology
Functional Genomics and Proteomics

Research Interests:

We are developing and applying functional genomics approaches for mapping genetic, chemical-genetic, and protein-protein interactions on a large-scale using the yeast model system. The ultimate goal is to place all yeast genes and their corresponding products on a functional network.

 

Currently Accepting Graduate Students

Gabrielle Boulianne

Gabrielle Boulianne, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8701

Web Site: http://sites.utoronto.ca/gboullab/


Research:

Development and function of the nervous system


Education:

Postdoctoral Fellow: University of Calilfornia, San Francisco
Ph.D.: University of Toronto
B.Sc.: McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

Research Interests:

 The Boulianne lab uses the fruit fly, Drosophila melanogaster, as a model to study the development and function of the nervous system and to establish models of human disease.

 

Currently Accepting Graduate Students

Julie Brill

Julie Brill, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9716, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8863



Web Site:   http://www.sickkids.ca/AboutSickKids/Directory/People/B/Julie-Brill-Staff-Profile.html


Research:

Phosphatidylinositol phosphates in animal development

Education:

Postdoctoral Fellow:  Stanford School of Medicine
Ph.D.: Massachusetts Institute of Technology
B.A.:  Swarthmore College


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

Research Interests:

 Phosphatidylinositol phosphates (PIPs) are membrane lipids with critical roles in cell signaling, yet little is known of their functions in animal development. Using Drosophila, we discovered novel roles for PIPs and their regulators in cytokinesis, gametogenesis and organelle biogenesis. Our future studies will uncover molecular mechanisms involved in these processes.


Currently Accepting Graduate Students

Martha Brown

Martha Brown, Ph.D.

Associate Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 4256
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-5853


Research:

Enteric adenoviruses


Education:

Postdoctoral Fellow: Hospital for Sick Children
Postdoctoral Fellow: Universite de Sherbrooke
M.Sc., Ph.D.: Queen's University
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

Research Interests:

The fastidious human enteric adenoviruses are a leading cause of pediatric diarrhea but do not cause disease in other tissues.  Research interests include: the unique structural features of these adenoviruses, how they enter intestinal cells, blocks to replication in other cells and development of these viruses as vaccine vectors.


Not Accepting Graduate Students

John Brumell

John Brumell, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 19-9706
686 Bay St.
Toronto, ON, M5G 0A4

Phone #: 416-813-3555

Web Site: http://www.sickkids.ca/...Brumell.html


Research:

How bacterial pathogens infect cells


Education:

Postdoctoral Fellow:  University of British Columbia
Postdoctoral Fellow:  SLRI, Mount Sinai Hospital
Ph.D.:  University of Toronto
B.Sc.:  University of Western Ontario


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

Research Interests:

My research examines how bacterial pathogens can infect our cells, and cause disease.

 

Currently Accepting Graduate Students

Eric Campos

Campos.jpg

Eric Campos, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 14.9706
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7400

Web Site: https://lab.research.sickkids.ca/campos


Research:

Histones and the inheritance of epigenetic information.


Education:

Postdoctoral Fellow: HHMI, New York University School of Medicine
Ph.D.:  University of British Columbia
B.Sc. (Hon): University of Ottawa


Fields of Interest:

  • Functional Genomics & Proteomics
  • Cellular & Molecular Structure & Function

Research Interests:

My laboratory focuses on histones and their role in epigenetic inheritance. Histones organize DNA by forming nucleosomes.  They influence chromatin structures and gene expression. We aim to understand how epigenetic information found on histones is transmitted through cell division, and how the process goes awry in a number of cancers.

 

Currently Accepting Graduate Students

Amy Caudy

Amy Caudy, Ph.D.

Assistant Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 308
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-4074

Web Site: http://tdccbr.med.utoronto.ca/...caudy.html


Research:

Metabolomics, cell growth and metabolism


Education:

Lewis-Sigler Fellow:  Princeton University
Postdoctoral Fellow:  Washington University
Ph.D.:  Watson School of Biological Sciences, Cold Spring Harbor Laboratory
B.A.:  Washington University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

Research Interests:

Discovery of novel enzymatic pathways using full scan LC-MS metabolomics, and characterization of the regulatory connections between cell growth and metabolism.

 

Currently Accepting Graduate Students

Hue Sun Chan

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Hue Sun Chan, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 5363
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-2697

Web Site: http://biochemistry.utoronto.ca/person/hue-sun-chan/

 


Research:

Theoretical and Computational Investigations of Protein Folding, Interactions, and Evolution


Education:

Postdoctoral Fellow:  University of California at San Francisco
Ph.D., University of California at Berkeley


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Computational and Systems Biology

Research Interests

Protein folding and interactions are physico-chemical processes.  Our group's overall research goal is to elucidate their underlying energetics. To this end, a main emphasis of our effort is to develop proteinlike heteropolymer models with coarse-grained interactions and simplified representations of chain geometries. The rationale of these approaches is to capture the essential physics and at the same time allow for a broad coverage of the protein conformational space - and also a broad coverage of the sequence space for evolutionary studies - that is not readily achievable currently in higher-resolution models.

Not Accepting Graduate Students

Brian Ciruna

Ciruna.jpg

Brian Ciruna, Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 302050

Web Site: http://www.sickkids.ca/...Brian-Ciruna-Staff-Profile.html


Research:

Zebrafish developmental genetics


Education:

Postdoctoral Fellow: New York University School of Medicine
Ph.D.:  University of Toronto
B.Sc. (Hon): University of Toronto


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

Research Interests:

Determine how polarized changes in cell shape, structure and movement ultimately form the vertebrate body during embryonic development.
Determine how abnormal cell polarity contributes to congenital malformations and disease (including scoliosis, polycystic kidney disease, and tumor metastasis).
Develop new technologies for zebrafish developmental genetic research.

 

Currently Accepting Graduate Students

Julie Claycomb

Julie Claycomb, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1535
Toronto, ON, M5G 1M1

Phone #: 416-978-3825

Web Site: http://individual.utoronto.ca/claycomblab/


Research:

Small RNA pathways in animal development


Education

Postdoctoral Fellow: University of Massachusetts Medical School
Ph.D.: Massachusetts Institute of Technology 
B.Sc. (Hon), B.A.:  University of Pittsburgh


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

Research Interests:

Research in the Claycomb lab is aimed at uncovering the molecular mechanisms by which small RNA pathways related to RNA interference modulate chromatin throughout animal development. Our studies exploit integrated experimental approaches including molecular genetics, genomics, and cell biology in the model nematode, C. elegans.

 

Currently Accepting Graduate Students

Alan Cochrane

Alan Cochrane, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Room 4383
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-2500


Research:

HIV-1 RNA processing by host factor


Education:

Postdoctoral Fellow: Roche Institute of Molecular Biology
Ph.D.: Queen's University
B.Sc.: McMaster University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

Research Interests:

HIV-1 replication is critically dependent upon tight regulation of RNA processing. From a single transcript, over 40 mRNAs are generated. My lab is focused on identify host cellular factors which regulate this process and characterizing small molecules that disrupt it in the hope of developing novel treatments for this disease.

 

Currently Accepting Graduate Students

 

Dr. Cochrane is an active member of the CanCURE research consortium (Canadian HIV Cure Enterprise) 

www.cancurehiv.org          

CanCURE logo_EN_COLOR.jpg

 

 

Ronald Cohn

Ronald Cohn, M.D.

Professor

Address:
Hospital for Sick Children
Div. of Metabolic & Clinical Genetics, Suite 960
525 University Ave.
Toronto ON M5G 1X8

Phone #: 416.813.7654 ext. 228780

Web Site: http://www.sickkids.ca/../.Ronald-Cohn.html


Research:

Paediatrics, Genetics, Molecular Biology of Neuromuscular Disorders


Education:

Postdoctoral Fellow:  University of Iowa and Johns Hopkins University
M.D.:  University of Essen, Germany

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

Research Interests:

Maintenance of muscle mass in inherited and acquired muscle disorders
Molecular mechanisms of muscle regeneration and fibrosis
Hypotonia with a particular focus on muscle and connective tissue disorders
Translating next generation sequencing into daily clinical diagnostics and management


Currently Accepting Graduate Students

Richard Collins

Richard Collins, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 4280
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-3541

Web Site: http://individual.utoronto.ca/collins_lab/


Research:

RNA and mitochondria


Education:

Postdoctoral Fellow:  St. Louis University 
Ph.D.:  University of Regina
B.Sc.:  University of Regina


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

Research Interests:

 We are interested in RNA and mitochondria, especially a natually-occurring Neurospora mitochondrial plasmid that encodes a catalytic RNA called the VS ribozyme. We are currently studying how such plasmids move between mitochondria, and whether they may be useful as vectors for genetic transformation of mitochondria.


Not Accepting Graduate Students