James Dennis, Ph.D.


Mount Sinai Hospital
LTRI Rm. 988
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8233

Web Site: http://dennislab.lunenfeld.ca/


Cell surface receptors and signaling


Postdoctoral Fellow:  University of Toronto
M.Sc., Ph.D.:  Queens University
B.Sc.:  Concordia University

Fields of Interest:

  • Computational and Systems Biology
  • Genetic Models of Development and Disease

Research Interests:

We study the regulation of cell surface receptors and signaling. Cell surface expression of receptors is dependent on N-glycosylation in the ER and modifications in the Golgi, which is in turn, sensitive to basic metabolism. Models include cell culture, mice and C. elegans, and phenotypes include cancer, immunity and stem cell maintenance.