Viewing entries in
Micro&Infectious Disease

Martha Brown

Martha Brown, Ph.D.

Associate Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 4256
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-5853


Research:

Enteric adenoviruses


Education:

Postdoctoral Fellow: Hospital for Sick Children
Postdoctoral Fellow: Universite de Sherbrooke
M.Sc., Ph.D.: Queen's University
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

The fastidious human enteric adenoviruses are a leading cause of pediatric diarrhea but do not cause disease in other tissues.  Research interests include: the unique structural features of these adenoviruses, how they enter intestinal cells, blocks to replication in other cells and development of these viruses as vaccine vectors.

 

Accepting Rotation Students:

No

 

John Brumell

John Brumell, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 19-9706
686 Bay St.
Toronto, ON, M5G 0A4

Phone #: 416-813-3555

Web Site: http://www.sickkids.ca/...Brumell.html


Research:

How bacterial pathogens infect cells


Education:

Postdoctoral Fellow:  University of British Columbia
Postdoctoral Fellow:  SLRI, Mount Sinai Hospital
Ph.D.:  University of Toronto
B.Sc.:  University of Western Ontario


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

My research examines how bacterial pathogens can infect our cells, and cause disease.

 

Accepting Rotation Students:

Yes

 

 

Alan Cochrane

Alan Cochrane, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Room 4383
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-2500


Research:

HIV-1 RNA processing by host factor


Education:

Postdoctoral Fellow: Roche Institute of Molecular Biology
Ph.D.: Queen's University
B.Sc.: McMaster University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

HIV-1 replication is critically dependent upon tight regulation of RNA processing. From a single transcript, over 40 mRNAs are generated. My lab is focused on identify host cellular factors which regulate this process and characterizing small molecules that disrupt it in the hope of developing novel treatments for this disease.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Dr. Cochrane is an active member of the CanCURE research consortium (Canadian HIV Cure Enterprise) 

www.cancurehiv.org          

CanCURE logo_EN_COLOR.jpg

 

 

Leah Cowen

Leah Cowen, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1638
Toronto, ON, M5G 1M1

Phone # :416-978-4085

Web Site: http://individual.utoronto.ca/cowen/index.html


Research:

Pathogenic fungi in evolution, development, and disease


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  University of Toronto
B.Sc.:  University of British Columbia


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Research in the Cowen lab exploits model and pathogenic fungi to address mechanisms governing evolution, development, drug resistance, and infectious disease.  We take an interdisciplinary approach incorporating genomics, proteomics, chemical genomics, molecular genetics, experimental evolution, and models of fungal pathogenesis.  Our work reveals novel therapeutic strategies for life-threatening infectious disease.

 

Accepting Rotation Students:

Yes

 

 

Alan Davidson

Alan Davidson, Ph.D

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1634
Toronto, ON, M5G 1M1

Phone #: 416-978-0332

Web Site: http://individual.utoronto.ca/Davidsonlab/index.html


Research:

Bacteriophages and CRISPR systems


Education:

Postdoctoral Fellow: Massachusetts Institute of Technology
Ph.D.: University of Toronto
B.Sc.: University of Toronto


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

My laboratory focuses on bacteriophages (phages), the viruses that infect bacteria.  We study how phages work, and how we can exploit phage-derived entities for applications in human health.  We also study anti-CRISPRs, which are phage-encoded inhibitors of CRISPR-Cas systems. We discovered these proteins, and are currently endeavouring to understand how they work, and how they can be exploited in genome editing applications.

 

Accepting Rotation Students:

Yes

 

 

Alex Ensminger

Alex Ensminger, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1637
Toronto, ON, M5G 1M1

Phone #: 416-978-6522

Web Site: http://individual.utoronto.ca/ensminger_lab/


Research:

Host-pathogen interactions and clinical microevolution of Legionella pneumophila


Education:

Postdoctoral Fellow: Tufts University School of Medicine
Ph.D.: Massachusetts Institute of Technology
B.Sc.: Haverford College


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

We use cutting-edge genomics, experimental evolution, and high-throughput robotics to study host-pathogen interactions and clinical microevolution. Our work is primarily focused on the causative agent of Legionnaires’ Disease, Legionella pneumophila, an often-fatal intracellular bacterial pathogen with a remarkably broad host range.

 

Accepting Rotation Students:

No

 

Lori Frappier

Lori Frappier, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1633
Toronto, ON, M5G 1M1

Phone #: 416-946-3501

Web Site: http://individual.utoronto.ca/frappierlab/index.html


Research:

How herpesvirus promote viral persistence and oncogenesis


Education:

Postdoctoral Fellow: Cornell University Medical College
Ph.D.: McGill University
B.Sc.: Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

We study how herpesvirus  proteins (particularly Epstein-Barr virus) manipulate nuclear processes to promote viral persistence and contribute to oncogenesis, often using proteomics methods.  We also study how PML nuclear bodies are regulated and disrupted by viral proteins, and the functions of a novel DNA replication protein that we discovered by proteomics.

 

Accepting Rotation Students:

Yes

 

Barbara Funnell

Barbara Funnell, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1632
Toronto, ON, M5G 1M1

Phone #: 416-978-1665

Web Site: http://individual.utoronto.ca/funnell_lab/


Research:

Chromosome dynamics, segregation of bacterial plasmids


Education:

Postdoctoral Fellow:  Stanford University
Ph.D.:  University of Wisconsin, Madison
B.Sc.:  McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our interest is chromosome dynamics, in particular, the segregation, or partition, of bacterial plasmids. Plasmids carry genes beneficial to their bacterial hosts but often harmful to us, such as antibiotic resistance and pathogenesis genes. We study the mechanism of partition using the P1 plasmid model system in Escherichia coli.

 

Accepting Rotation Students:

No

 

Scott Gray-Owen

Gray-Owen.jpg

Scott Gray-Owen, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Room 4381
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-946-5307


Research:

Pathogen interactions of human-restricted bacterial and viral pathogens


Education:

Postdoctoral Fellow:  Max Planck Insitut für Biologie, Germany
Ph.D.: University of Calgary  
B.Sc.: University of Calgary


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our research aims to understand how human-restricted bacterial pathogens colonize host tissues and evade the host’s otherwise effective immune response. Our paradigm is the pathogenic Neisseria sp., which includes the bacteria that cause the sexually transmitted disease gonorrhea and rapidly progressing invasive meningococcal meningitis. These bacteria are highly adapted to life in humans, undergoing constant evolution of surface antigens via a combination of antigenic and phase variation, and actively suppressing both innate and adaptive immune responses. Our studies in this regard have led to the development of more relevant in vitro and in vivo models of neisserial infection and disease; to a detailed description of molecular processes that occur downstream of immune activating and inhibitory carcinoembryonic antigen-related cellular adhesion molecule (CEACAM)-related proteins; to reveal a previously unrecognized ‘pathogen-associated molecular pattern’ (PAMP) that allows innate immune detection of bacterial in the tissues; to provide new molecular and immunological insights into the epidemiological synergy between sexually transmitted gonorrhea and HIV-1; to the development of novel vaccines with the potential to broadly protect against neisserial infection; and to the development of a new class of antibiotics that function by activating cylindrical proteases within the bacterial cytoplasm. 

 Publications (Pubmed)   

 

Accepting Rotation Students:

No

 

Sadhna Joshi

Joshi.jpg

Sadhna Joshi, D.Sc.

Associate Professor

Address:
Room 4377, Medical Sciences Building
1 King’s College Circle
Toronto, ON M5S 1A8

Phone #: 416-978-2499

Web Site: http://drsadhnajoshi.weebly.com/


Research:

Genetic strategies for HIV-1 prevention


Education:

Postdoctoral Fellow: University of Leiden, The Netherlands
D.Sc., Ph.D.: University of Paris VII, Paris, France
B.Sc.: University Paris VII, Paris, France


Fields of Interest:

Molecular Microbiology and Infectious Disease

 

Research Interests:

Research in my laboratory is focused on the development of genetic strategies for HIV-1 prevention (microflora defense) and treatment (gene therapy). Genes encoding secreted bi- and tri-functional antiviral proteins that inhibit HIV-1 infection of unmodified target cells are used for this purpose.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Jun Liu

Liu.jpg

Jun Liu, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1615
Toronto, ON, M5G 1M1

Phone #: 416-946-5067

Web Site: http://sites.utoronto.ca/liulab/


Research:

Novel strategies for the control of tuberculosis, and design of effective TB vaccines


Education:

Postdoctoral Fellow:  University of California, Berkeley
Ph.D.:  Medical College of Wisconsin
B.Sc.:  Peking University, China


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

Research Interests:

Our research goal is to develop novel strategies for the control of tuberculosis, one of the world’s most deadly infectious diseases.  We are working on understanding how Mycobacterium tuberculosis maintains persistent infection in the host and how to rationally design the next generation of effective TB vaccines.

 

Currently Accepting Graduate Students

William Navarre

William Navarre, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1635
Toronto, ON, M5G 1M1

Phone #: 416-946-5356

Web Site: http://sites.utoronto.ca/navlab


Research:

Molecular mechanisms controlling the expression of genes required for bacterial virulence


Education:

Postdoctoral Fellow: University of Washington School of Medicine
Postdoctoral Fellow:  New York University School of Medicine
Ph.D.:  University of California, Los Angeles
B.S.: University of Michigan


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Research in the Navarre lab is aimed at understanding the molecular mechanisms controlling  the expression of genes required for bacterial virulence.  The lab has a central focus on genomic evolution and lateral gene transfer, which plays a primary role in the evolution of pathogens and the rapid spread of antibiotic resistance.

 

Accepting Rotation Students:

Yes

 

John Parkinson

John Parkinson, Ph.D.

Professor

Address:
Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Rm. 21.9709
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-5746

Web Site: http://www.compsysbio.org/


Research:

Evolution and operation of biological systems that pertain to human disease


Education:

Postdoctoral Fellow:   University of Manitoba
Postdoctoral Fellow:   University of Edinburgh, U.K.
Ph.D.:  University of Manchester, U.K.
B.Sc. (Hon): University of Bath, U.K.


Fields of Interest:

  • Computational and Systems Biology
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our labs interests are focused on the evolution and operation of biological systems, particularly those that pertain to human disease. Specific systems of interests include those that allow bacterial pathogens and parasites to survive and persist within their human hosts. In collaboration with the NIH, we are actively developing and applying novel integrative strategies that combine mathematical models with functional genomics to target parasite metabolism.

 

Accepting Rotation Students:

Yes