Viewing entries in
Models of Dev. & Disease

Brenda Andrews

Brenda Andrews, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1308
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-8562

Web Site: http://sites.utoronto.ca/andrewslab/homepage.html


Research:

Studying simple yeast cells to understand human cells


Education:

Postdoctoral Fellow: University of California, San Francisco
Ph.D.: University of Toronto
B.Sc.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

The Andrews lab uses functional genomics coupled with yeast genetics and cell biology to study cell cycle transcription factor pathways and mechanisms of cell cycle regulation. Current projects include: 1) systematic synthetic dosage lethality (SDL) screens using automated yeast genetics to define targets of protein kinases; 2) a 'phenomics' project that uses high through put fluorescence microscopy to define biological networks and to map cell cycle transcription factor pathways; 3) collaborations with the Boone, Hughes and other labs to map genetic networks controlling cell cycle progression and cell polarity in yeast.

 

Accepting Rotation Students:

Yes

 

 

 

 

Alan Bernstein

Alan Bernstein

Adjunct Professor

Address:
Canadian Institute for Advanced Research, Suite 505
MaRS West Tower, 661 University Ave.
Toronto, ON M5G 1M1

Phone #: 416-971-4255

Web Site: http://www.cifar.ca/cifar-staff


Research:

Intersection of research and public policy, especially science policy


Education

Postdoctoral Fellow:  Imperial Cancer Research Laboratories, U.K.
M.Sc, Ph.D.:  University of Toronto
B.Sc.:  University of Waterloo


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My current research interests centre around the intersection of research and public policy, especially with regard to science policy.

 

Accepting Rotation Students:

N/A

 

Gabrielle Boulianne

Gabrielle Boulianne, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8701

Admin: iris.biberstein@sickkids.ca

Web Site: http://sites.utoronto.ca/gboullab/


Research:

Development and function of the nervous system


Education:

Postdoctoral Fellow: University of Calilfornia, San Francisco
Ph.D.: University of Toronto
B.Sc.: McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

 The Boulianne lab uses the fruit fly, Drosophila melanogaster, as a model to study the development and function of the nervous system and to establish models of human disease.

 

Accepting Rotation Students:

No

 

Julie Brill

Julie Brill, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9716, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8863



Web Site:   http://www.sickkids.ca/AboutSickKids/Directory/People/B/Julie-Brill-Staff-Profile.html


Research:

Phosphatidylinositol phosphates in animal development

Education:

Postdoctoral Fellow:  Stanford School of Medicine
Ph.D.: Massachusetts Institute of Technology
B.A.:  Swarthmore College


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

 Phosphatidylinositol phosphates (PIPs) are membrane lipids with critical roles in cell signaling, yet little is known of their functions in animal development. Using Drosophila, we discovered novel roles for PIPs and their regulators in cytokinesis, gametogenesis and organelle biogenesis. Our future studies will uncover molecular mechanisms involved in these processes.

 

Accepting Rotation Students:

No

 

Brian Ciruna

Ciruna.jpg

Brian Ciruna, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 302050

Admin: iris.biberstein@sickkids.ca

Web Site: http://www.sickkids.ca/...Brian-Ciruna-Staff-Profile.html


Research:

Zebrafish developmental genetics


Education:

Postdoctoral Fellow: New York University School of Medicine
Ph.D.:  University of Toronto
B.Sc. (Hon): University of Toronto


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Determine how polarized changes in cell shape, structure and movement ultimately form the vertebrate body during embryonic development.
Determine how abnormal cell polarity contributes to congenital malformations and disease (including scoliosis, polycystic kidney disease, and tumor metastasis).
Develop new technologies for zebrafish developmental genetic research.

 

Accepting Rotation Students:

Yes

 

 

Julie Claycomb

Julie Claycomb, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1535
Toronto, ON, M5G 1M1

Phone #: 416-978-3825

Web Site: http://individual.utoronto.ca/claycomblab/


Research:

Small RNA pathways in animal development


Education

Postdoctoral Fellow: University of Massachusetts Medical School
Ph.D.: Massachusetts Institute of Technology
B.Sc. (Hon), B.A.:  University of Pittsburgh


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Research in the Claycomb lab is aimed at uncovering the molecular mechanisms by which small RNA pathways related to RNA interference modulate chromatin throughout animal development. Our studies exploit integrated experimental approaches including molecular genetics, genomics, and cell biology in the model nematode, C. elegans.

 

Accepting Rotation Students:

Yes

 

 

Joe Culotti

Joe Culotti, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI Rm.846
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8244


Research:

Mechanism of axon guidance and cell migration


Education:

Postdoctoral Fellow: Max Planck Institute for Experimental Medicine
Postdoctoral Fellow: California Institute of Technology
Ph.D.: University of Washington
B.Sc.:  University of California, Irvine


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Our research focuses on the molecular mechanisms of axon growth and guidance as well as the molecular mechanisms of cell migration.

 

James Dennis

James Dennis, Ph.D.

Professor

Address:
Mount Sinai Hospital
LTRI Rm. 988
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8233

Web Site: http://dennislab.lunenfeld.ca/


Research:

Cell surface receptors and signaling


Education:

Postdoctoral Fellow:  University of Toronto
M.Sc., Ph.D.:  Queens University
B.Sc.:  Concordia University


Fields of Interest:

  • Computational and Systems Biology
  • Genetic Models of Development and Disease

Research Interests:

We study the regulation of cell surface receptors and signaling. Cell surface expression of receptors is dependent on N-glycosylation in the ER and modifications in the Golgi, which is in turn, sensitive to basic metabolism. Models include cell culture, mice and C. elegans, and phenotypes include cancer, immunity and stem cell maintenance.

 

Brent Derry

Brent Derry, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 18-9714
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301829

Admin: taylor.becker@sickkids.ca

Web Site: http://lab.research.sickkids.ca/derry


Research:

Apoptosis and DNA repair in C. elegans


Education:

Postdoctoral Fellow:  University of California, Santa Barbara
Ph.D.: University of California, Santa Barbara
M.Sc.:  Carleton University
B.Sc.:  McMaster University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We are interested in cell autonomous and cell-nonautonomous mechanisms of apoptosis and DNA repair in the nematode worm C. elegans. We are also interested in understanding mechanisms by which the cerebral cavernous malformation (CCM) proteins control excretory canal development.

 

Accepting Rotation Students:

Yes

 

John Dick

John Dick, Ph.D.

Professor

Address:
UHN, MaRS Centre
TMDT Bldg., East Tower Rm 8-358
101 College St.
Toronto, ON, M5G 1L7

Phone #: 416-581-7472

Web Site: http://jdstemcellresearch.ca/


Research:

Human hematopoiesis and leukemogenesis


Education:

Postdoctoral Fellow:  OCI & Mt. Sinai Hospital Research Institute
Ph.D.:  University of Manitoba
B.Sc. (Hon):  University of Manitoba


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Understanding human hematopoiesis and leukemogenesis using unique human tissue based models to examine critical genes, proteins, or epigenetic factors in these processes
Pursuing pre-clinical studies of therapeutics and whether they are targeting cancer stem cells
Exploring potential biomarkers that may stratify leukemia patients and advance personalized medicine.

 

Accepting Rotation Students:

No

 

Peter Dirks

Peter Dirks, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-6426

Admin: nahed.mojadiddi@sickkids.ca

Web Site: http://www.sickkids.ca/Research/Dirks-Lab/index.html


Research:

Stem cells in brain cancer


Education:

Clinical Fellowship: University Rene Descartes, Paris
Ph.D.:  University of Toronto
M.D.: Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Our laboratory is interested in applying the conceptual and methodologic framework of stem cell biology to the study of brain cancer. In our view, brain cancer is a caricature of normal development but with aberrant molecular regulation of self renewal and differentiation. We study both human brain cancer and mouse models of brain cancer to ask questions about cell of origin, nature of the cells that propagate cancer growth, and explore novel therapeutic targets using genetic and small molecule approaches.

 

Accepting Rotation Students:

Yes

 

James Dowling

James Dowling, M.D., Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, 15-9703
686 Bay St.
Toronto ON M5G 0A4

Phone #: 416-813-8980 (x308980)

Admin: irina.iovu@sickkids.ca

Website:

http://www.sickkids.ca/AboutSickKids/Directory/People/D/James-Dowling-Staff-Profile.html


Research:

diseases of skeletal muscle, phosphoinositide signalling, zebrafish


Education:

Postdoctoral Fellow:  University of Michigan
M.D., Ph.D.:  University of Chicago;   Residency: Children's Hospital of Philadelphia
B.Sc., M.Sc.:  Yale University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory seeks to understand the pathogenic mechanisms of and develop therapies for childhood muscle diseases.  We combine gene discovery and model systems research to define disease pathology and identify treatments.  Our favorite model system is the zebrafish, and we are interested in the role of endolysosomes in muscle biology.

 

Accepting Rotation Students:

Yes

 

Sean Egan

Egan.jpg

Sean Egan, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9704
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-5267

Admin: iris.biberstein@sickkids.ca

Web Site: http://www.sickkids.ca/.../Sean-Egan.html


Research:

Mouse models of breast cancer and development


Education:

Postdoctoral Fellow:  The Whitehead Institute/Massachusetts Institute of Technology
Ph.D.:  University of Manitoba, Department of Microbiology
B.Sc. (Hon): University of Manitoba


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

Research Interests:

The Egan lab uses mouse models to study breast cancer and mouse development. For example, we use gene targeting to design models for breast cancer which can be probed to define cooperative signaling networks that are involved in transformation and metastasis, and that can be targeted in the clinic.

 

James Ellis

James Ellis, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9715
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7295

Admin: nahed.mojadiddi@sickkids.ca

Web Site: http://lab.research.sickkids.ca/ellis/


Research:

Induced pluripotent stem (iPS) cells


Education:

Postdoctoral Fellow:  National Institute for Medical Research, U.K.
Ph.D.: University of Toronto
B.Sc. (Hon): McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

We reprogram patient skin cells into induced pluripotent stem (iPS) cells to study Autism, Cystic Fibrosis and Congenital Heart Disease. The affected cell types are derived from iPS cells for drug discovery. We also study stem cell chromatin structure and generate retrovirus vectors to deliver reporter genes into stem cells.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Andrew Fraser

Andrew Fraser, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre
Rm. 1212, 160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-2712

Web Site: http://www.fraserlab.org/


Research:

How variations in genome sequence affect phenotype in C. elegans


Education:

Postdoctoral Fellow: Wellcome/CRC Institute, U.K.
Postdoctoral Fellow: Cold Spring Harbor
Ph.D.:  University of London, U.K.
B.Sc. - University of Cambridge, U.K.


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We want to understand how variations in genome sequence affect phenotype in health and disease. To do this, we use the nematode worm as a simple model system in which we can perturb the function of any gene in any genetic background and learn how to predict the outcome.

 

Accepting Rotation Students:

No

 

Sevan Hopyan

Sevan Hopyan, M.D.-Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9713
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301266

Admin: nahed.mojadiddi@sickkids.ca

Web Site: https://lab.research.sickkids.ca/hopyan/

 


Research:

Morphogenetic mechanisms that shape the limb bud


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Clinical Fellow:  Royal Children's Hospital, Australia
M.D., Ph.D.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My lab studies morphogenetic mechanisms that shape the initial limb bud and what early molecular events specify skeletal pattern. Our goals are to quantitatively model limb bud growth in 4D, and use what we learn to bioengineer a limb bud in a dish. We also identify mutations that cause human anomalies.

 

Accepting Rotation Students:

No

 

Chi Chung Hui

Chi Chung Hui, D.Sc.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-4994

Admin: katheline.aguilar@sickkids.ca

Web site: http://lab.research.sickkids.ca/hui/

 


Research:

Genetic control of animal development and tumorigenesis


Education:

Postdoctoral Fellow:  National Institute for Basic Biology, Japan
Postdoctoral Fellow: Samuel Lunenfeld Research Institute, Toronto
D.Sc. (Ph.D.): Nagoya University, Japan
M. Phil.: University of Hong Kong
B.Sc. (Hon):   University of Hong Kong


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

We are interested in understanding the genetic control of animal development and the molecular mechanisms involved in tumorigenesis.  We utilize molecular genetic approaches in mice to examine how Gli transcription factors are regulated by Hedgehog-dependent and -independent mechanisms, and the function of Iroquois transcription factors in heart and limb development.

 

Accepting Rotation Students:

Yes

 

Monica Justice

Justice.jpg

Monica Justice, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 14-9716
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 x309199

Admin: catherine.tan@sickkids.ca

Web Site: http://lab.research.sickkids.ca/justice/


Research:

Mouse Modeling / Clinical Genetics
Additional Affiliations
Head and Senior Scientist, Program in Genetics and Genome Biology, SickKids


Education:

Postdoctoral Fellow: National Cancer Institute - Frederick Cancer Research and Development Center
Ph.D.: Kansas State University
B.Sc.: Fort Hayes State University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Dr Justice’s research aims to merge mouse modeling with clinical genetics to understand the basis for human diseases, and to exploit models to improve disease symptoms. Two major projects are 1) eliminating tumour-initiating cells in childhood cancers and 2) discovering pathways for therapeutic intervention in Rett Syndrome through genetic suppressors.

 

Accepting Rotation Students:

Yes

 

David Kaplan

Kaplan.jpg

David Kaplan, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 18-9715
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301433

Admin: taylor.becker@sickkids.ca

Web Site: http://lab.research.sickkids.ca/miller-kaplan/

 


Research:

Genes and signaling pathways regulating neurodegeneration and neuronal survival


Education:

Postdoctoral Fellow:  University of California, San Francisco
Ph.D.:  Harvard University
B.A.:  Clark University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

We focus on identifying and characterizing the genes and signaling pathways regulating neurodegeneration and neuronal survival, how stem cells build and repair the brain, on developing drugs to mobilize our stem cells to repair injuries and degeneration, and discovering new drugs to treat brain and childhood cancers.

 

Accepting Rotation Students:

No

 

Tae-Hee Kim

Tae-Hee Kim, Ph.D.

ASSIsTANT PROFESSOR

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research and Learning
686 Bay St., Room 16.9709
Toronto, ON, M5G 0A4

Phone #: 416-813-8138

Admin: michelle.driz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/kim

 


RESEARCH:

Mechanisms of gastro-intestinal stem cells


EDUCATION:

Postdoctoral Fellow: Dana-Farber Cancer Institute / Harvard University
Ph.D.: Cornell University / Sloan-Kettering Institute
M.Sc.: University of Illinois at Urbana-Champaign                                                                                                                 B.Sc.: Sungkyunkwan University


FIELDS OF INTEREST:

  • Genetic Models of Development and Disease
  • Cellular & Molecular Structure & Function

 

RESEARCH INTERESTS:

We are interested in the mechanisms of stem cell renewal and differentiation and their perturbation in diseases such as cancer. Using the gut as a model system and applying mouse genetics, epigenomics and gut organoid cultures, we investigate signaling, chromatin modification and the transcriptional basis of gastrointestinal stem cells.

 

Accepting Rotation Students:

Contact PI directly for more information.