Viewing entries in
Structure & Function

Irene Andrulis

Irene Andrulis, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI, Room 984
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8256

Web Site: http://www.lunenfeld.ca/researchers/Andrulis


Research:

Genetic alterations in breast cancer and sarcoma


Education:

Postdoctoral Fellow:  University of Toronto
Ph.D.:  University of California, Irvine
B.Sc.:  University of Pennsylvania


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory conducts multi-disciplinary studies to identify genetic alterations that play a role in breast cancer and sarcoma and to determine their clinical importance.  Our goals are to explore the biology of these genetic alterations, to aid in diagnosis and treatment, and to discover novel targets for therapeutics.

 

Accepting Rotation Students:

No

 

Benjamin Blencowe

Benjamin Blencowe, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1016
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-3016

Web Site: http://sites.utoronto.ca/intron/


Research:

Regulation of gene expression and alternative splicing


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  EMBL, Heidelberg, Germany and University of London, UK
B.Sc (Hon):  Imperial College London, UK


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

Our research focuses on mechanisms underlying the regulation of gene expression and how these mechanisms go awry in human diseases. Most of our research is directed at understanding how alternative splicing is integrated with other layers of gene regulation to control fundamental biological processes, such as cell fate determination.

 

Accepting Rotation Students:

Yes

 

 

Gabrielle Boulianne

Gabrielle Boulianne, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8701

Admin: iris.biberstein@sickkids.ca

Web Site: http://sites.utoronto.ca/gboullab/


Research:

Development and function of the nervous system


Education:

Postdoctoral Fellow: University of Calilfornia, San Francisco
Ph.D.: University of Toronto
B.Sc.: McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

 The Boulianne lab uses the fruit fly, Drosophila melanogaster, as a model to study the development and function of the nervous system and to establish models of human disease.

 

Accepting Rotation Students:

No

 

Julie Brill

Julie Brill, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9716, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8863



Web Site:   http://www.sickkids.ca/AboutSickKids/Directory/People/B/Julie-Brill-Staff-Profile.html


Research:

Phosphatidylinositol phosphates in animal development

Education:

Postdoctoral Fellow:  Stanford School of Medicine
Ph.D.: Massachusetts Institute of Technology
B.A.:  Swarthmore College


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

 Phosphatidylinositol phosphates (PIPs) are membrane lipids with critical roles in cell signaling, yet little is known of their functions in animal development. Using Drosophila, we discovered novel roles for PIPs and their regulators in cytokinesis, gametogenesis and organelle biogenesis. Our future studies will uncover molecular mechanisms involved in these processes.

 

Accepting Rotation Students:

No

 

Martha Brown

Martha Brown, Ph.D.

Associate Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 4256
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-5853


Research:

Enteric adenoviruses


Education:

Postdoctoral Fellow: Hospital for Sick Children
Postdoctoral Fellow: Universite de Sherbrooke
M.Sc., Ph.D.: Queen's University
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

The fastidious human enteric adenoviruses are a leading cause of pediatric diarrhea but do not cause disease in other tissues.  Research interests include: the unique structural features of these adenoviruses, how they enter intestinal cells, blocks to replication in other cells and development of these viruses as vaccine vectors.

 

Accepting Rotation Students:

No

 

John Brumell

John Brumell, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 19-9706
686 Bay St.
Toronto, ON, M5G 0A4

Phone #: 416-813-3555

Web Site: http://www.sickkids.ca/...Brumell.html


Research:

How bacterial pathogens infect cells


Education:

Postdoctoral Fellow:  University of British Columbia
Postdoctoral Fellow:  SLRI, Mount Sinai Hospital
Ph.D.:  University of Toronto
B.Sc.:  University of Western Ontario


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

My research examines how bacterial pathogens can infect our cells, and cause disease.

 

Accepting Rotation Students:

Yes

 

 

Amy Caudy

Amy Caudy, Ph.D.

Assistant Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 308
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-4074

Web Site: http://tdccbr.med.utoronto.ca/...caudy.html


Research:

Metabolomics, cell growth and metabolism


Education:

Lewis-Sigler Fellow:  Princeton University
Postdoctoral Fellow:  Washington University
Ph.D.:  Watson School of Biological Sciences, Cold Spring Harbor Laboratory
B.A.:  Washington University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

Discovery of novel enzymatic pathways using full scan LC-MS metabolomics, and characterization of the regulatory connections between cell growth and metabolism.

 

Accepting Rotation Students:

No

 

Brian Ciruna

Ciruna.jpg

Brian Ciruna, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 302050

Admin: iris.biberstein@sickkids.ca

Web Site: http://www.sickkids.ca/...Brian-Ciruna-Staff-Profile.html


Research:

Zebrafish developmental genetics


Education:

Postdoctoral Fellow: New York University School of Medicine
Ph.D.:  University of Toronto
B.Sc. (Hon): University of Toronto


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Determine how polarized changes in cell shape, structure and movement ultimately form the vertebrate body during embryonic development.
Determine how abnormal cell polarity contributes to congenital malformations and disease (including scoliosis, polycystic kidney disease, and tumor metastasis).
Develop new technologies for zebrafish developmental genetic research.

 

Accepting Rotation Students:

Yes

 

 

Julie Claycomb

Julie Claycomb, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1535
Toronto, ON, M5G 1M1

Phone #: 416-978-3825

Web Site: http://individual.utoronto.ca/claycomblab/


Research:

Small RNA pathways in animal development


Education

Postdoctoral Fellow: University of Massachusetts Medical School
Ph.D.: Massachusetts Institute of Technology
B.Sc. (Hon), B.A.:  University of Pittsburgh


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Research in the Claycomb lab is aimed at uncovering the molecular mechanisms by which small RNA pathways related to RNA interference modulate chromatin throughout animal development. Our studies exploit integrated experimental approaches including molecular genetics, genomics, and cell biology in the model nematode, C. elegans.

 

Accepting Rotation Students:

Yes

 

 

Alan Cochrane

Alan Cochrane, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Room 4383
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-2500


Research:

HIV-1 RNA processing by host factor


Education:

Postdoctoral Fellow: Roche Institute of Molecular Biology
Ph.D.: Queen's University
B.Sc.: McMaster University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

HIV-1 replication is critically dependent upon tight regulation of RNA processing. From a single transcript, over 40 mRNAs are generated. My lab is focused on identify host cellular factors which regulate this process and characterizing small molecules that disrupt it in the hope of developing novel treatments for this disease.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Dr. Cochrane is an active member of the CanCURE research consortium (Canadian HIV Cure Enterprise) 

www.cancurehiv.org          

CanCURE logo_EN_COLOR.jpg

 

 

Richard Collins

Richard Collins, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 4280
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-3541

Web Site: http://individual.utoronto.ca/collins_lab/


Research:

RNA and mitochondria


Education:

Postdoctoral Fellow:  St. Louis University
Ph.D.:  University of Regina
B.Sc.:  University of Regina


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

 We are interested in RNA and mitochondria, especially a natually-occurring Neurospora mitochondrial plasmid that encodes a catalytic RNA called the VS ribozyme. We are currently studying how such plasmids move between mitochondria, and whether they may be useful as vectors for genetic transformation of mitochondria.

 

Joe Culotti

Joe Culotti, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI Rm.846
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8244


Research:

Mechanism of axon guidance and cell migration


Education:

Postdoctoral Fellow: Max Planck Institute for Experimental Medicine
Postdoctoral Fellow: California Institute of Technology
Ph.D.: University of Washington
B.Sc.:  University of California, Irvine


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Our research focuses on the molecular mechanisms of axon growth and guidance as well as the molecular mechanisms of cell migration.

 

Alan Davidson

Alan Davidson, Ph.D

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1634
Toronto, ON, M5G 1M1

Phone #: 416-978-0332

Web Site: http://individual.utoronto.ca/Davidsonlab/index.html


Research:

Bacteriophages and CRISPR systems


Education:

Postdoctoral Fellow: Massachusetts Institute of Technology
Ph.D.: University of Toronto
B.Sc.: University of Toronto


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

My laboratory focuses on bacteriophages (phages), the viruses that infect bacteria.  We study how phages work, and how we can exploit phage-derived entities for applications in human health.  We also study anti-CRISPRs, which are phage-encoded inhibitors of CRISPR-Cas systems. We discovered these proteins, and are currently endeavouring to understand how they work, and how they can be exploited in genome editing applications.

 

Accepting Rotation Students:

Yes

 

 

Daniel Durocher

Daniel Durocher, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI, Rm.1073
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 ext 2544

Web Site: http://research.lunenfeld.ca/durocher


Research:

Molecular basis of genome integrity


Education:

Postdoctoral Fellow: University of Cambridge
Ph.D. McGill University
B.Sc. Université de Montréal


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

I am interested in understanding the molecular basis of genome integrity. Our research is ultimately relevant to cancer, aging, evolution and stem cell biology.

 

Accepting Rotation Students:

Yes

 

James Ellis

James Ellis, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9715
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7295

Admin: michelle.driz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/ellis/


Research:

Induced pluripotent stem (iPS) cells


Education:

Postdoctoral Fellow:  National Institute for Medical Research, U.K.
Ph.D.: University of Toronto
B.Sc. (Hon): McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

We reprogram patient skin cells into induced pluripotent stem (iPS) cells to study Autism, Cystic Fibrosis and Congenital Heart Disease. The affected cell types are derived from iPS cells for drug discovery. We also study stem cell chromatin structure and generate retrovirus vectors to deliver reporter genes into stem cells.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Oliver Ernst

Oliver Ernst, Dr. rer. nat

Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 5259
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-3849


Research:

G Protein-coupled receptors (GPCRs) mechanism, specificity and structure


Education:

Postdoctoral Fellow/Habilitation: Charité - Universitätsmedizin Berlin, Germany
Ph.D./Dr. rer. nat.: Albert-Ludwigs-Universität, Freiburg, Germany


Fields of Interest:

  • Cellular and Molecular Structure and Function

Research Interests

 Cell membranes are natural borders for signal transduction between cells and their environment. Different strategies to enable signals to cross the membrane barrier employ protein classes such as G protein-coupled receptors (GPCRs), ion channels, and transporters. Our research is directed at understanding transmembrane signaling by GPCRs. We investigate the inner workings of these proteins and their interaction with signaling proteins like G proteins and arrestins. Using different spectroscopic techniques and X-ray crystallography, we aim to get insight into the mechanism, specificity and structural basis of these interactions. A focus of our work is on rhodopsin, the photoreceptor protein in the vertebrate retina. The knowledge how GPCRs work on a molecular level will help to understand their role in health and disease.

 

Lori Frappier

Lori Frappier, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1633
Toronto, ON, M5G 1M1

Phone #: 416-946-3501

Web Site: http://individual.utoronto.ca/frappierlab/index.html


Research:

How herpesvirus promote viral persistence and oncogenesis


Education:

Postdoctoral Fellow: Cornell University Medical College
Ph.D.: McGill University
B.Sc.: Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

We study how herpesvirus  proteins (particularly Epstein-Barr virus) manipulate nuclear processes to promote viral persistence and contribute to oncogenesis, often using proteomics methods.  We also study how PML nuclear bodies are regulated and disrupted by viral proteins, and the functions of a novel DNA replication protein that we discovered by proteomics.

 

Accepting Rotation Students:

Yes

 

Barbara Funnell

Barbara Funnell, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1632
Toronto, ON, M5G 1M1

Phone #: 416-978-1665

Web Site: http://individual.utoronto.ca/funnell_lab/


Research:

Chromosome dynamics, segregation of bacterial plasmids


Education:

Postdoctoral Fellow:  Stanford University
Ph.D.:  University of Wisconsin, Madison
B.Sc.:  McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our interest is chromosome dynamics, in particular, the segregation, or partition, of bacterial plasmids. Plasmids carry genes beneficial to their bacterial hosts but often harmful to us, such as antibiotic resistance and pathogenesis genes. We study the mechanism of partition using the P1 plasmid model system in Escherichia coli.

 

Accepting Rotation Students:

No

 

Scott Gray-Owen

Gray-Owen.jpg

Scott Gray-Owen, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Room 4381
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-946-5307


Research:

Pathogen interactions of human-restricted bacterial and viral pathogens


Education:

Postdoctoral Fellow:  Max Planck Insitut für Biologie, Germany
Ph.D.: University of Calgary  
B.Sc.: University of Calgary


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our research aims to understand how human-restricted bacterial pathogens colonize host tissues and evade the host’s otherwise effective immune response. Our paradigm is the pathogenic Neisseria sp., which includes the bacteria that cause the sexually transmitted disease gonorrhea and rapidly progressing invasive meningococcal meningitis. These bacteria are highly adapted to life in humans, undergoing constant evolution of surface antigens via a combination of antigenic and phase variation, and actively suppressing both innate and adaptive immune responses. Our studies in this regard have led to the development of more relevant in vitro and in vivo models of neisserial infection and disease; to a detailed description of molecular processes that occur downstream of immune activating and inhibitory carcinoembryonic antigen-related cellular adhesion molecule (CEACAM)-related proteins; to reveal a previously unrecognized ‘pathogen-associated molecular pattern’ (PAMP) that allows innate immune detection of bacterial in the tissues; to provide new molecular and immunological insights into the epidemiological synergy between sexually transmitted gonorrhea and HIV-1; to the development of novel vaccines with the potential to broadly protect against neisserial infection; and to the development of a new class of antibiotics that function by activating cylindrical proteases within the bacterial cytoplasm. 

 Publications (Pubmed)   

 

Accepting Rotation Students:

No

 

Jack Greenblatt

Jack Greenblatt, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 960
160 College Street
Toronto, ON M5S 3E1

Phone #: 416-978-4141

Web Site: http://sites.utoronto.ca/greenblattlab/


Research:

Protein-protein and protein-RNA interaction networks for chromatin-related proteins and DNA-binding transcription factors


Education:

Postdoctoral Fellow:  Pasteur Institute, Paris
Ph.D.: Harvard University
B.Sc. (Hon): McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Computational and Systems Biology

 

Research Interests:

Our current major aims are using affinity purification/mass spectrometry and second-generation sequencing to establish protein-protein and protein-RNA interaction networks for the approximately 900 human chromatin-related proteins and  >1000 human DNA-binding transcription factors, as well as to identify some of their important functions in transcription and their relationships to human diseases.

 

Accepting Rotation Students:

Yes