Viewing entries in
CP - Developmental Biolog

Gabrielle Boulianne

Gabrielle Boulianne, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8701

Admin: iris.biberstein@sickkids.ca

Web Site: http://sites.utoronto.ca/gboullab/


Research:

Development and function of the nervous system


Education:

Postdoctoral Fellow: University of Calilfornia, San Francisco
Ph.D.: University of Toronto
B.Sc.: McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

 The Boulianne lab uses the fruit fly, Drosophila melanogaster, as a model to study the development and function of the nervous system and to establish models of human disease.

 

Accepting Rotation Students:

No

 

Julie Brill

Julie Brill, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9716, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8863



Web Site:   http://www.sickkids.ca/AboutSickKids/Directory/People/B/Julie-Brill-Staff-Profile.html


Research:

Phosphatidylinositol phosphates in animal development

Education:

Postdoctoral Fellow:  Stanford School of Medicine
Ph.D.: Massachusetts Institute of Technology
B.A.:  Swarthmore College


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

 Phosphatidylinositol phosphates (PIPs) are membrane lipids with critical roles in cell signaling, yet little is known of their functions in animal development. Using Drosophila, we discovered novel roles for PIPs and their regulators in cytokinesis, gametogenesis and organelle biogenesis. Our future studies will uncover molecular mechanisms involved in these processes.

 

Accepting Rotation Students:

No

 

Brian Ciruna

Ciruna.jpg

Brian Ciruna, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 302050

Admin: iris.biberstein@sickkids.ca

Web Site: http://www.sickkids.ca/...Brian-Ciruna-Staff-Profile.html


Research:

Zebrafish developmental genetics


Education:

Postdoctoral Fellow: New York University School of Medicine
Ph.D.:  University of Toronto
B.Sc. (Hon): University of Toronto


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Determine how polarized changes in cell shape, structure and movement ultimately form the vertebrate body during embryonic development.
Determine how abnormal cell polarity contributes to congenital malformations and disease (including scoliosis, polycystic kidney disease, and tumor metastasis).
Develop new technologies for zebrafish developmental genetic research.

 

Accepting Rotation Students:

Yes

 

 

Julie Claycomb

Julie Claycomb, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1535
Toronto, ON, M5G 1M1

Phone #: 416-978-3825

Web Site: http://individual.utoronto.ca/claycomblab/


Research:

Small RNA pathways in animal development


Education

Postdoctoral Fellow: University of Massachusetts Medical School
Ph.D.: Massachusetts Institute of Technology
B.Sc. (Hon), B.A.:  University of Pittsburgh


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Research in the Claycomb lab is aimed at uncovering the molecular mechanisms by which small RNA pathways related to RNA interference modulate chromatin throughout animal development. Our studies exploit integrated experimental approaches including molecular genetics, genomics, and cell biology in the model nematode, C. elegans.

 

Accepting Rotation Students:

Yes

 

 

Sabine Cordes

Sabine Cordes, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI. Rm.865
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8891


Research:

Mouse neurodevelopment, neuronal function and angiogenesis


Education:

Postdoctoral Fellow:  Stanford University
Ph.D.:  University of California, Berkeley
B.Sc.:  University of  California, Berkeley


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

We combine mouse genetics with molecular analyses in vitro and other model organisms to understand the molecular mechanisms that govern neurodevelopment, neuronal function and angiogenesis (blood vessel branching). This approach may lead towards new insights and therapies for human disorders of mood and mind, as well as anti-angiogenic therapies.

 

Accepting Rotation Students:

Yes

 

 

Joe Culotti

Joe Culotti, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI Rm.846
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8244


Research:

Mechanism of axon guidance and cell migration


Education:

Postdoctoral Fellow: Max Planck Institute for Experimental Medicine
Postdoctoral Fellow: California Institute of Technology
Ph.D.: University of Washington
B.Sc.:  University of California, Irvine


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Our research focuses on the molecular mechanisms of axon growth and guidance as well as the molecular mechanisms of cell migration.

 

Brent Derry

Brent Derry, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 18-9714
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301829

Admin: michelle.driz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/derry


Research:

Apoptosis and DNA repair in C. elegans


Education:

Postdoctoral Fellow:  University of California, Santa Barbara
Ph.D.: University of California, Santa Barbara
M.Sc.:  Carleton University
B.Sc.:  McMaster University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Functional Genomics and Proteomics

 

Research Interests:

We are interested in cell autonomous and cell-nonautonomous mechanisms of apoptosis and DNA repair in the nematode worm C. elegans. We are also interested in understanding mechanisms by which the cerebral cavernous malformation (CCM) proteins control excretory canal development.

 

Accepting Rotation Students:

Yes

 

James Dowling

James Dowling, M.D., Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, 15-9703
686 Bay St.
Toronto ON M5G 0A4

Phone #: 416-813-8980 (x308980)

Admin: irina.iovu@sickkids.ca

Website:

http://www.sickkids.ca/AboutSickKids/Directory/People/D/James-Dowling-Staff-Profile.html


Research:

diseases of skeletal muscle, phosphoinositide signalling, zebrafish


Education:

Postdoctoral Fellow:  University of Michigan
M.D., Ph.D.:  University of Chicago;   Residency: Children's Hospital of Philadelphia
B.Sc., M.Sc.:  Yale University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory seeks to understand the pathogenic mechanisms of and develop therapies for childhood muscle diseases.  We combine gene discovery and model systems research to define disease pathology and identify treatments.  Our favorite model system is the zebrafish, and we are interested in the role of endolysosomes in muscle biology.

 

Accepting Rotation Students:

Yes

 

Sean Egan

Egan.jpg

Sean Egan, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9704
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-5267

Admin: iris.biberstein@sickkids.ca

Web Site: http://www.sickkids.ca/.../Sean-Egan.html


Research:

Mouse models of breast cancer and development


Education:

Postdoctoral Fellow:  The Whitehead Institute/Massachusetts Institute of Technology
Ph.D.:  University of Manitoba, Department of Microbiology
B.Sc. (Hon): University of Manitoba


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

Research Interests:

The Egan lab uses mouse models to study breast cancer and mouse development. For example, we use gene targeting to design models for breast cancer which can be probed to define cooperative signaling networks that are involved in transformation and metastasis, and that can be targeted in the clinic.

 

Sevan Hopyan

Sevan Hopyan, M.D.-Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9713
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301266

Admin: stella.umana@sickkids.ca

Web Site: https://lab.research.sickkids.ca/hopyan/

 


Research:

Morphogenetic mechanisms that shape the limb bud


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Clinical Fellow:  Royal Children's Hospital, Australia
M.D., Ph.D.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

My lab studies morphogenetic mechanisms that shape the initial limb bud and what early molecular events specify skeletal pattern. Our goals are to quantitatively model limb bud growth in 4D, and use what we learn to bioengineer a limb bud in a dish. We also identify mutations that cause human anomalies.

 

Accepting Rotation Students:

No

 

Chi Chung Hui

Chi Chung Hui, D.Sc.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-4994

Admin: katheline.aguilar@sickkids.ca

Web site: http://lab.research.sickkids.ca/hui/

 


Research:

Genetic control of animal development and tumorigenesis


Education:

Postdoctoral Fellow:  National Institute for Basic Biology, Japan
Postdoctoral Fellow: Samuel Lunenfeld Research Institute, Toronto
D.Sc. (Ph.D.): Nagoya University, Japan
M. Phil.: University of Hong Kong
B.Sc. (Hon):   University of Hong Kong


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

We are interested in understanding the genetic control of animal development and the molecular mechanisms involved in tumorigenesis.  We utilize molecular genetic approaches in mice to examine how Gli transcription factors are regulated by Hedgehog-dependent and -independent mechanisms, and the function of Iroquois transcription factors in heart and limb development.

 

Accepting Rotation Students:

Yes

 

Henry Krause

Henry Krause, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 502
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-8602

Web Site: http://sites.utoronto.ca/krause


Research:

Drosophila and Zebrafish genome-scale approaches to understanding development and disease


Education:

Postdoctoral Fellow:  Biozentrum, Switzerland
Ph.D.: University of Alabama, Birmingham
B.Sc.: McGill University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

Our lab is using live animal (Drosophila and zebrafish), genome-scale approaches to understand developmental and disease processes. We have also developed animal models to screen for new drugs that control diseases such as diabetes, cancer and depression.

 

Accepting Rotation Students:

No

 

Howard Lipshitz

Howard Lipshitz, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1538
Toronto, ON M5G 1M1

Phone #: 416-946-5296

Web Site: http://sites.utoronto.ca/flylab


Research:

Post-transcriptional regulation of gene expression in Drosophila with a focus on RNA-binding proteins and small RNAs


Education:

Postdoctoral Fellow:  Stanford University
M.Phil., Ph.D.:  Yale University
B.Sc., B.Sc.(Hon):  University of Natal, Durban, South Africa 


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We study post-transcriptional regulation of gene expression in Drosophila with a focus on RNA-binding proteins and small RNAs that regulate the stability, subcellular localization and translation of maternal mRNAs in early embryos. We use gene-by-gene and genome-wide analyses of the transcriptome, ribonome and proteome.

 

Accepting Rotation Students:

Yes

 

Marc Meneghini

Meneghini.jpg

Marc Meneghini, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1532
Toronto, ON, M5G 1M1

Phone #: 416-978-7578

Web Site: http://sites.utoronto.ca/molgen/Site/home.html


Research:

Saccharomyces cerevisiae epigenetic control of gene expression during sporulation and novel form of programed death


Education:

Postdoctoral Fellow:  University of California, San Francisco
Ph.D.:  University of Oregon
B.S.:  St. Michael's College


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

The lab’s interests concern mechanisms of eukaryotic cellular differentiation. As a model, we use the sporulation program of the budding yeast Saccharomyces cerevisiae. We study epigenetic mechanisms controlling gene expression during sporulation as well as a new and novel form of programmed death we have recently discovered accompanies this process.

 

Accepting Rotation Students:

Yes

 

Bret Pearson

Bret Pearson, Ph.D.

Associate Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for Research &
Learning, Rm. 18-9713, 686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 328370

Admin: meera.kamal@sickkids.ca

Web Site: 

http://lab.research.sickkids.ca/pearson/

 

 


Research:

Planarian as an in vivo model system to study stem cells and regeneration

Education:

Postdoctoral Fellow:  University of Utah    
Ph.D.:  University of Oregon
B.S.:  University of Wisconsin, Madison
 

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics


Research Interests:

We focus on how adult stem cells make a correct cell lineage in space and time to replace the exact number of cells lost to tissue turnover or injury. To this end, my lab uses the freshwater planarian as an in vivo model system to study stem cells and regeneration.

 

Accepting Rotation Students:

Yes

 

Janet Rossant

Janet Rossant, Ph.D.

Professor

Address:
Hospital for Sick Children, PGCRL Rm. 16.9705
686 Bay St.
Toronto, ON, M5G 0A4

Phone #: 416-813-7929

Admin: katheline.aguilar@sickkids.ca

Web Site: http://lab.research.sickkids.ca/rossant/


Research:

Mechanisms of cell fate decisions in the early mouse embryo and embryo-derived stem cells


Education:

Postdoctoral Fellow:  Oxford University
Ph.D.:  Cambridge University
B.A. (Hon), M.A.:  Oxford University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

The Rossant lab is interested in mechanisms of cell fate decisions in the early mouse embryo and their application to the maintenance and differentiation of embryo-derived stem cells.

 

Accepting Rotation Students:

No

 

Peter Roy

Peter Roy, Ph.D.

Professor

Address:
University of Toronto,
The Donnelly Centre, Rm. 1202
160 College St.,
Toronto, ON, M5S 3E1

Phone #: 416-946-8395

Web Sitehttp://roylab.ccbr.utoronto.ca

 


Education:

Posdoctoral Fellow:  Stanford University
Ph.D.:  University of Toronto
B.Sc.:  Dalhousie University

 

Fields of Interest:

  • Molecular Medicine and Human Genetics

  • Genetic Models of Development and Disease

 

Research:

The Roy Lab is exploiting the nematode worm C. elegans to identify new small molecule tools for animal research and drug development.  Projects in the Roy Lab include the development of compounds to kill parasitic nematodes that infect over 2 billion humans, as well as those nematode parasites that result in billions of dollars of lost productivity in agriculture.  En route towards the development of new drug leads, the Roy Lab works to better understand how animals protect themselves against exogenous small molecules.

 

Accepting Rotation Students:

Yes

 

Ian Scott

Ian Scott, Ph.D.

Associate Professor

Address:

Hospital for Sick Children,
Peter Gilgan Centre for Research
& Learning, Rm. 16.9707
686 Bay St., Toronto,
ON, M5G 0A4

Phone #: 416 813-7654 ext 301572

Admin: katheline.aguilar@sickkids.ca

Web Sitehttp://www.sickkids.ca/AboutSickKids/Directory/People/S/Ian-C-Scott.html


Research:

Cardiovascular development and heart regeneration in zebrafish
 

Education:

Postdoctoral Fellow: University of California, San Francisco
Ph.D.:  University of Toronto
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

Research Interests:

Analysis of cardiovascular development and heart regeneration using the zebrafish model.  We are interested in uncovering the molecular and cellular events that govern embryonic heart development and adult heart regeneration, and applying these discoveries to methods to repair the damaged human heart.

 

Accepting Rotation Students:

Yes

 

Craig Smibert

Craig Smibert, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1537
Toronto, ON, M5G 1M1

Phone #: 416-946-5538

Web Sitehttp://biochemistry.utoronto.ca/person/craig-a-smibert/

 


Research:

Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation

Education:

Postdoctoral Fellow: Stanford University
Ph.D.:  McMaster University
B.Sc.:  McMaster University
 

Fields of Interest:

  • Functional Genomics and Proteomics
  • Genetic Models of Development and Disease
     

Research Interests:

Post-transcriptional regulation of gene expression is achieved through the control of mRNA translation, mRNA stability and subcellular mRNA localization. Post-transcriptional regulation is mediated by RNA-binding proteins and regulatory RNAs that recognize specific sequences within target transcripts. We use both Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation.

 

Accepting Rotation Students:

Yes

 

Andrew Spence

Andrew Spence, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1501
Toronto, ON, M5G 1M1

Phone #: 416-978-6406

Web Sitehttp://www.spencelab.ca


Research:

Determination of sex-specific cell fates in Caenorhabditis elegans via a novel form of epigenetic regulation
 

Education:

Postdoctoral Fellow:  MRC Laboratory of Molecular Biology, U.K.
Ph.D.:  University of British Columbia
B.Sc.:  University of Winnipeg
 

Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

Research Interests:

We study genes that determine sex-specific cell fates in Caenorhabditis elegans. We have described a novel form of epigenetic regulation that depends upon maternally contributed RNA to license gene expression in the germ line of the next generation, and we are using genetic and genomic approaches to understand its mechanism.

 

Accepting Rotation Students:

No