Viewing entries in
Medicine & Human Genetics

Irene Andrulis

Irene Andrulis, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI, Room 984
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8256

Web Site: http://www.lunenfeld.ca/researchers/Andrulis


Research:

Genetic alterations in breast cancer and sarcoma


Education:

Postdoctoral Fellow:  University of Toronto
Ph.D.:  University of California, Irvine
B.Sc.:  University of Pennsylvania


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory conducts multi-disciplinary studies to identify genetic alterations that play a role in breast cancer and sarcoma and to determine their clinical importance.  Our goals are to explore the biology of these genetic alterations, to aid in diagnosis and treatment, and to discover novel targets for therapeutics.

 

Accepting Rotation Students:

No

 

Alan Bernstein

Alan Bernstein

Adjunct Professor

Address:
Canadian Institute for Advanced Research, Suite 505
MaRS West Tower, 661 University Ave.
Toronto, ON M5G 1M1

Phone #: 416-971-4255

Web Site: http://www.cifar.ca/cifar-staff


Research:

Intersection of research and public policy, especially science policy


Education

Postdoctoral Fellow:  Imperial Cancer Research Laboratories, U.K.
M.Sc, Ph.D.:  University of Toronto
B.Sc.:  University of Waterloo


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

My current research interests centre around the intersection of research and public policy, especially with regard to science policy.

 

 

John Dick

John Dick, Ph.D.

Professor

Address:
UHN, MaRS Centre
TMDT Bldg., East Tower Rm 8-358
101 College St.
Toronto, ON, M5G 1L7

Phone #: 416-581-7472

Web Site: http://jdstemcellresearch.ca/


Research:

Human hematopoiesis and leukemogenesis


Education:

Postdoctoral Fellow:  OCI & Mt. Sinai Hospital Research Institute
Ph.D.:  University of Manitoba
B.Sc. (Hon):  University of Manitoba


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Understanding human hematopoiesis and leukemogenesis using unique human tissue based models to examine critical genes, proteins, or epigenetic factors in these processes
Pursuing pre-clinical studies of therapeutics and whether they are targeting cancer stem cells
Exploring potential biomarkers that may stratify leukemia patients and advance personalized medicine.

 

Accepting Rotation Students:

No

 

Peter Dirks

Peter Dirks, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-6426

Admin: stella.umana@sickkids.ca

Web Site: http://www.sickkids.ca/Research/Dirks-Lab/index.html


Research:

Stem cells in brain cancer


Education:

Clinical Fellowship: University Rene Descartes, Paris
Ph.D.:  University of Toronto
M.D.: Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

Our laboratory is interested in applying the conceptual and methodologic framework of stem cell biology to the study of brain cancer. In our view, brain cancer is a caricature of normal development but with aberrant molecular regulation of self renewal and differentiation. We study both human brain cancer and mouse models of brain cancer to ask questions about cell of origin, nature of the cells that propagate cancer growth, and explore novel therapeutic targets using genetic and small molecule approaches.

 

Accepting Rotation Students:

Yes

 

James Dowling

James Dowling, M.D., Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, 15-9703
686 Bay St.
Toronto ON M5G 0A4

Phone #: 416-813-8980 (x308980)

Admin: irina.iovu@sickkids.ca

Website:

http://www.sickkids.ca/AboutSickKids/Directory/People/D/James-Dowling-Staff-Profile.html


Research:

diseases of skeletal muscle, phosphoinositide signalling, zebrafish


Education:

Postdoctoral Fellow:  University of Michigan
M.D., Ph.D.:  University of Chicago;   Residency: Children's Hospital of Philadelphia
B.Sc., M.Sc.:  Yale University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory seeks to understand the pathogenic mechanisms of and develop therapies for childhood muscle diseases.  We combine gene discovery and model systems research to define disease pathology and identify treatments.  Our favorite model system is the zebrafish, and we are interested in the role of endolysosomes in muscle biology.

 

Accepting Rotation Students:

Yes

 

Aled Edwards

Aled Edwards, Ph.D.

Professor

Address:
Structural Genome Consortium
MaRS South Tower Rm. 701 
101 College St.
Toronto, ON, M5G 1L5

Phone #:416-946-0237

Web Site: http://www.thesgc.org/about/director


Research:

Developing open access research tools (chemical inhibitors, protein structures and recombinant antibodies)
Additional Affiliations
Structural Genomics Consortium

*currently on leave from Dept. of Molecular Genetics while serving as Director of SGC


Education:

Postdoctoral Fellow: Stanford University
Ph.D.: McGill University
B.Sc.: McGill University


Fields of Interest:

  • Functional Genomics and Proteomics

  • Molecular Medicine and Human Genetics

Research Interests:

Developing open access research tools (chemical inhibitors, protein structures and recombinant antibodies) to increase knowledge of human biology and accelerate drug discovery

 

Sevan Hopyan

Sevan Hopyan, M.D.-Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9713
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301266

Admin: stella.umana@sickkids.ca

Web Site: https://lab.research.sickkids.ca/hopyan/

 


Research:

Morphogenetic mechanisms that shape the limb bud


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Clinical Fellow:  Royal Children's Hospital, Australia
M.D., Ph.D.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

My lab studies morphogenetic mechanisms that shape the initial limb bud and what early molecular events specify skeletal pattern. Our goals are to quantitatively model limb bud growth in 4D, and use what we learn to bioengineer a limb bud in a dish. We also identify mutations that cause human anomalies.

 

Accepting Rotation Students:

No

 

Lucy Osborne

Osborne.jpg

Lucy Osborne, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1515
Toronto, ON, M5G 1M1

Phone #: 416-946-5804

Web Site: http://individual.utoronto.ca/osbornelab/


Research:

Mouse models and the genetic analysis of human subjects to probe the molecular basis of neurodevelopmental disorders


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Ph.D.:  National Heart & Lung Institute, U.K.
M.Sc.: University College London, U.K.
B.Sc. (Hon): City of London Polytechnic, U.K. 


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Both deletion and duplication of human chromosome 7q11.23 cause neurodevelopmental disorders with unique phenotypic profiles, so offering a window into the genetics of human behavior, cognition and language. We use mouse models and the genetic analysis of human subjects to probe the underlying molecular basis of these disorders.

 

Accepting Rotation Students:

No

 

 

Bret Pearson

Bret Pearson, Ph.D.

Associate Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for Research &
Learning, Rm. 18-9713, 686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 328370

Admin: meera.kamal@sickkids.ca

Web Site: 

http://lab.research.sickkids.ca/pearson/

 

 


Research:

Planarian as an in vivo model system to study stem cells and regeneration

Education:

Postdoctoral Fellow:  University of Utah    
Ph.D.:  University of Oregon
B.S.:  University of Wisconsin, Madison
 

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics


Research Interests:

We focus on how adult stem cells make a correct cell lineage in space and time to replace the exact number of cells lost to tissue turnover or injury. To this end, my lab uses the freshwater planarian as an in vivo model system to study stem cells and regeneration.

 

Accepting Rotation Students:

Yes

 

Johanna Rommens

Johanna Rommens, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 14-9712
686 Bay St., 
Toronto, ON M5G 0A4

Phone #: 416-813-7095

Web Site: http://www.sickkids.ca/...Rommens.html 


Research:

Human genetic diseases of the exocrine pancreas, including cystic fibrosis and Schwachman-Diamond syndrome


Education:

Postdoctoral Fellow:  The Hospital for Sick Children, Toronto
Ph.D.:  University of New Brunswick
B.Sc. (Hon): University of New Brunswick


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory is interested in human genetic diseases of the exocrine pancreas, including cystic fibrosis and Shwachman-Diamond syndrome.  We use population studies and mouse models to investigate the mechanisms underlying development and presentation of exocrine pancreatic failure.

 

Accepting Rotation Students:

No

 

Frederick Roth

Frederick Roth, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 912
160 College St. Toronto, ON
M5S 3E1

Phone #: 416-946-5130

Website: http://llama.mshri.on.ca/


Research:

Developing experimental and computational technology to more relate genes and proteins to the functioning of living systems and human disease


Education:

Ph.D.:  Harvard University
B.A.:  University of California, Berkeley


Fields of Interest:

  • Computational and Systems Biology

  • Molecular Medicine and Human Genetics


Research Interests:

Roth's group is focused on developing experimental and computational technology to more efficiently relate genes and proteins to each other and to the functioning of living systems and human disease.

 

Accepting Rotation Students:

Yes

 

Stephen Scherer

Stephen Scherer, Ph.D.

 

Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for
Research & Learning,
Rm. 13-9705,
686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7613

Admin:  elainec.chang@sickkids.ca

Web Sitehttp://www.tcag.ca/scherer/


Research:

Human genome structure and function, genomic of neurodevelopmental disorders
 

Education:

M.Sc., Ph.D.:  University of Toronto
B.Sc. (Hon):  University of Waterloo
 

Fields of Interest:

  • Computational and Systems Biology

  • Molecular Medicine and Human Genetics

Research Interests:

Human genome structure and function, genomics of autism and other neurodevelopmental disorders

 

Accepting Rotation Students:

No