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Kenichi Okamoto

Kenichi Okamoto, Ph.D.

Assistant Professor

Address:
Mount Sinai Hospital
LTRI Rm.884
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 ext.4936

Web Site: http://www.lunenfeld.ca/researchers/okamoto


Research:

Developing novel technologies to visualize and manipulate protein function in the brain


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  Osaka University, Japan
M.A.:  Toyama University, Japan
B.S.:  Toyama University, Japan


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Elucidating the mechanisms of learning and memory is essential for understanding brain diseases such as Alzheimer’s disease and Autism. We aim to dissect the complex signaling cascades for learning & memory and related brain diseases by developing novel technologies to visualize and manipulate protein function in the brain.

 

Accepting Rotation Students:

Yes

 

Lucy Osborne

Osborne.jpg

Lucy Osborne, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1515
Toronto, ON, M5G 1M1

Phone #: 416-946-5804

Web Site: http://individual.utoronto.ca/osbornelab/


Research:

Mouse models and the genetic analysis of human subjects to probe the molecular basis of neurodevelopmental disorders


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Ph.D.:  National Heart & Lung Institute, U.K.
M.Sc.: University College London, U.K.
B.Sc. (Hon): City of London Polytechnic, U.K. 


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Both deletion and duplication of human chromosome 7q11.23 cause neurodevelopmental disorders with unique phenotypic profiles, so offering a window into the genetics of human behavior, cognition and language. We use mouse models and the genetic analysis of human subjects to probe the underlying molecular basis of these disorders.

 

Accepting Rotation Students:

No

 

 

John Parkinson

John Parkinson, Ph.D.

Professor

Address:
Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Rm. 21.9709
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-5746

Web Site: http://www.compsysbio.org/


Research:

Evolution and operation of biological systems that pertain to human disease


Education:

Postdoctoral Fellow:   University of Manitoba
Postdoctoral Fellow:   University of Edinburgh, U.K.
Ph.D.:  University of Manchester, U.K.
B.Sc. (Hon): University of Bath, U.K.


Fields of Interest:

  • Computational and Systems Biology
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our labs interests are focused on the evolution and operation of biological systems, particularly those that pertain to human disease. Specific systems of interests include those that allow bacterial pathogens and parasites to survive and persist within their human hosts. In collaboration with the NIH, we are actively developing and applying novel integrative strategies that combine mathematical models with functional genomics to target parasite metabolism.

 

Accepting Rotation Students:

Yes

 

Bret Pearson

Bret Pearson, Ph.D.

Associate Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for Research &
Learning, Rm. 18-9713, 686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 328370

Admin: meera.kamal@sickkids.ca

Web Site: 

http://lab.research.sickkids.ca/pearson/

 

 


Research:

Planarian as an in vivo model system to study stem cells and regeneration

Education:

Postdoctoral Fellow:  University of Utah    
Ph.D.:  University of Oregon
B.S.:  University of Wisconsin, Madison
 

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics


Research Interests:

We focus on how adult stem cells make a correct cell lineage in space and time to replace the exact number of cells lost to tissue turnover or injury. To this end, my lab uses the freshwater planarian as an in vivo model system to study stem cells and regeneration.

 

Accepting Rotation Students:

Yes

 

Christopher Pearson

Christopher Pearson, Ph.D.

Professor

Address:
Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Rm. 14-9714, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8256

Admin: Irina.Iovu@sickkids.ca

Web Site: http://www.cepearsonlab.com/


Research:

DNA repeat instability


Education:

Postdoctoral Fellow:  Texas Medical Center
Ph.D.:  McGill University
B.Sc. (Hon):  Concordia University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

Understand DNA repeat instability; the cause of >40 diseases including Huntington's disease, muscular dystrophy & amyotrophic lateral sclerosis.
Use molecular, stem cell, transgenic mouse models and human tissues to understand and modulate this mutation for clinical benefit.
Focus on DNA repair, replication & epigenetics.
Identify therapeutic targets and preclinical therapeutic drugs.

 

Accepting Rotation Students:

Yes

 

Laurence Pelletier

Laurence Pelletier, Ph.D.

Professor

Address:
Mt. Sinai Hospital, LTRI, Room 1070
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 x6196

Web Site: http://pelletierlab.org


Research:

Centrosome biogenesis and function


Education:

Ph.D.:  Yale University
M.Sc.:  University of Montreal
B.Sc.:  University of Montreal


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

Our laboratory studies several facets of centrosome biogenesis and function, with a particular emphasis on how their perturbation can lead to genome instability, developmental diseases and cancer. Using functional genomic approaches and cutting-edge microscopy and biochemistry, our overarching goal is to identify and study novel proteins required centrosome and to investigate their potential role in development and diseases.

 

Accepting Rotation Students:

Yes

 

James Rini

James Rini, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1614
Toronto, ON, M5G 1M1

Phone #: 416-978-0557
 


Research:

Using X-ray crystallography and biochemistry to study protein folding and coronavirus-host cell receptor interactions


Education

Postdoctoral Fellow:  Research Institute of Scripps Clinic, California
Ph.D.:  University of Toronto
B.Sc.:  University of Toronto


Fields of Interest

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests

Our research is focused on the study of: i) ER-resident glycosyltransferases and their role in protein folding and quality control, and ii) coronavirus-host cell receptor interactions. In all cases we seek to determine structure-function relationships using x-ray crystallography and complementary biochemical and cell-based approaches.

 

Accepting Rotation Students:

No

 

Johanna Rommens

Johanna Rommens, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 14-9712
686 Bay St., 
Toronto, ON M5G 0A4

Phone #: 416-813-7095

Web Site: http://www.sickkids.ca/...Rommens.html 


Research:

Human genetic diseases of the exocrine pancreas, including cystic fibrosis and Schwachman-Diamond syndrome


Education:

Postdoctoral Fellow:  The Hospital for Sick Children, Toronto
Ph.D.:  University of New Brunswick
B.Sc. (Hon): University of New Brunswick


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory is interested in human genetic diseases of the exocrine pancreas, including cystic fibrosis and Shwachman-Diamond syndrome.  We use population studies and mouse models to investigate the mechanisms underlying development and presentation of exocrine pancreatic failure.

 

Accepting Rotation Students:

No

 

Janet Rossant

Janet Rossant, Ph.D.

Professor

Address:
Hospital for Sick Children, PGCRL Rm. 16.9705
686 Bay St.
Toronto, ON, M5G 0A4

Phone #: 416-813-7929

Admin: katheline.aguilar@sickkids.ca

Web Site: http://lab.research.sickkids.ca/rossant/


Research:

Mechanisms of cell fate decisions in the early mouse embryo and embryo-derived stem cells


Education:

Postdoctoral Fellow:  Oxford University
Ph.D.:  Cambridge University
B.A. (Hon), M.A.:  Oxford University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

The Rossant lab is interested in mechanisms of cell fate decisions in the early mouse embryo and their application to the maintenance and differentiation of embryo-derived stem cells.

 

Accepting Rotation Students:

No

 

Frederick Roth

Frederick Roth, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 912
160 College St. Toronto, ON
M5S 3E1

Phone #: 416-946-5130

Website: http://llama.mshri.on.ca/


Research:

Developing experimental and computational technology to more relate genes and proteins to the functioning of living systems and human disease


Education:

Ph.D.:  Harvard University
B.A.:  University of California, Berkeley


Fields of Interest:

  • Computational and Systems Biology

  • Molecular Medicine and Human Genetics


Research Interests:

Roth's group is focused on developing experimental and computational technology to more efficiently relate genes and proteins to each other and to the functioning of living systems and human disease.

 

Accepting Rotation Students:

Yes

 

Peter Roy

Peter Roy, Ph.D.

Professor

Address:
University of Toronto,
The Donnelly Centre, Rm. 1202
160 College St.,
Toronto, ON, M5S 3E1

Phone #: 416-946-8395

Web Sitehttp://roylab.ccbr.utoronto.ca

 


Education:

Posdoctoral Fellow:  Stanford University
Ph.D.:  University of Toronto
B.Sc.:  Dalhousie University

 

Fields of Interest:

  • Molecular Medicine and Human Genetics

  • Genetic Models of Development and Disease

 

Research:

The Roy Lab is exploiting the nematode worm C. elegans to identify new small molecule tools for animal research and drug development.  Projects in the Roy Lab include the development of compounds to kill parasitic nematodes that infect over 2 billion humans, as well as those nematode parasites that result in billions of dollars of lost productivity in agriculture.  En route towards the development of new drug leads, the Roy Lab works to better understand how animals protect themselves against exogenous small molecules.

 

Accepting Rotation Students:

Yes

 

Stephen Scherer

Stephen Scherer, Ph.D.

 

Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for
Research & Learning,
Rm. 13-9705,
686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7613

Admin:  elainec.chang@sickkids.ca

Web Sitehttp://www.tcag.ca/scherer/


Research:

Human genome structure and function, genomic of neurodevelopmental disorders
 

Education:

M.Sc., Ph.D.:  University of Toronto
B.Sc. (Hon):  University of Waterloo
 

Fields of Interest:

  • Computational and Systems Biology

  • Molecular Medicine and Human Genetics

Research Interests:

Human genome structure and function, genomics of autism and other neurodevelopmental disorders

 

Accepting Rotation Students:

No

 

Ian Scott

Ian Scott, Ph.D.

Professor

Address:

Hospital for Sick Children,
Peter Gilgan Centre for Research
& Learning, Rm. 16.9707
686 Bay St., Toronto,
ON, M5G 0A4

Phone #: 416 813-7654 ext 301572

Admin: katheline.aguilar@sickkids.ca

Web Sitehttp://www.sickkids.ca/AboutSickKids/Directory/People/S/Ian-C-Scott.html


Research:

Cardiovascular development and heart regeneration in zebrafish
 

Education:

Postdoctoral Fellow: University of California, San Francisco
Ph.D.:  University of Toronto
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

Research Interests:

Analysis of cardiovascular development and heart regeneration using the zebrafish model.  We are interested in uncovering the molecular and cellular events that govern embryonic heart development and adult heart regeneration, and applying these discoveries to methods to repair the damaged human heart.

 

Accepting Rotation Students:

Yes

 

Frank Sicheri

Frank Sicheri, Ph.D.

Professor

Address:
Mount Sinai Hospital,
LTRI Room 1090A,
600 University Ave,
Toronto, ON, M5G 1X5

Phone #: 416-586-8471

Web Sitehttp://research.lunenfeld.ca/sicheri/


Research:

Mechanisms of action of signaling molecules studied with X-ray crystallography and biochemical techniques
 

Education:

Postdoctoral Fellow:  Rockefeller University
Ph.D.:  McMaster University
B.Sc. (Hon):  McMaster University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Computational and Systems Biology

Research Interests:

Research in the Sicheri lab is focused on elucidating the mechanism of action of signalling molecules through the use of x-ray crystallography and biochemical techniques.

 

Accepting Rotation Students:

Yes

 

Sachdev Sidhu

Sachdev Sidhu, Ph.D.

Professor

Address:
University of Toronto,
The Donnelly Centre, Rm. 816
160 College St., Toronto, ON, M5S 3E1

Phone #: 416-946-0863

Web Sitehttp://sites.utoronto.ca/sidhulab/


Research:

Protein engineering to design synthetic antibodies to target and modulate protein-protein interactions

Education:

Postdoctoral Fellow:  Genentech Inc., California
Ph.D.:  Simon Fraser University
B.Sc. (Hon):  Simon Fraser University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Functional Genomics and Proteomics

Research Interests:

My group uses protein engineering to design synthetic antibodies and other proteins to target and modulate the natural protein-protein interactions. We use these synthetic agents to investigate the roles of key protein-protein interactions in normal and diseased cellular states with the aim of developing novel therapuetics.

 

Accepting Rotation Students:

Yes

 

Craig Smibert

Craig Smibert, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1537
Toronto, ON, M5G 1M1

Phone #: 416-946-5538

Web Sitehttp://biochemistry.utoronto.ca/person/craig-a-smibert/

 


Research:

Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation

Education:

Postdoctoral Fellow: Stanford University
Ph.D.:  McMaster University
B.Sc.:  McMaster University
 

Fields of Interest:

  • Functional Genomics and Proteomics
  • Genetic Models of Development and Disease
     

Research Interests:

Post-transcriptional regulation of gene expression is achieved through the control of mRNA translation, mRNA stability and subcellular mRNA localization. Post-transcriptional regulation is mediated by RNA-binding proteins and regulatory RNAs that recognize specific sequences within target transcripts. We use both Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation.

 

Accepting Rotation Students:

Yes

 

Andrew Spence

Andrew Spence, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1501
Toronto, ON, M5G 1M1

Phone #: 416-978-6406

Web Sitehttp://www.spencelab.ca


Research:

Determination of sex-specific cell fates in Caenorhabditis elegans via a novel form of epigenetic regulation
 

Education:

Postdoctoral Fellow:  MRC Laboratory of Molecular Biology, U.K.
Ph.D.:  University of British Columbia
B.Sc.:  University of Winnipeg
 

Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

Research Interests:

We study genes that determine sex-specific cell fates in Caenorhabditis elegans. We have described a novel form of epigenetic regulation that depends upon maternally contributed RNA to license gene expression in the germ line of the next generation, and we are using genetic and genomic approaches to understand its mechanism.

 

Accepting Rotation Students:

No

 

Igor Stagljar

Igor Stagljar, Ph.D.

Professor

Address:
University of Toronto,
Donnelly Centre, Rm. 1204
160 College St., Toronto, ON M5S 3E1

Phone #: 416-946-7828

Web Sitehttp://biochemistry.utoronto.ca/stagljar/


Research:

Studies of yeast and human integral membrane proteins in cell signaling and membrane transport at a system level

Education:

Postdoctoral Fellow:  University of Zurich & University of Washington (Seattle)
Ph.D.:  Swiss Federal Institute of Technology (ETH) Zurich, Switzerland
B.Sc.:  University of Zagreb, Croatia
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics
     

Research Interests:

A focus of my lab is to understand the function of the majority of “druggable” yeast and human integral membrane proteins involved in cell signaling and membrane transport at a systems level. Despite extensive research in the past decade, there is a lack of in-depth understanding of protein networks associated with these integral membrane proteins because of their unique biochemical features, enormous complexity and multiplicity. This is a major obstacle for designing improved and more targeted therapies, and importantly, understanding the biology of deregulation of these integral membrane proteins which leads to numerous human diseases.  To address this challenge, we are applying an in vivo genetic system previously developed in my lab, called the membrane yeast two-hybrid (MYTH) assay, to identify and characterize protein interactors of all yeast ABC transporters and human receptor tyrosine kinases (RTKs), as well as selected cancer stem cell receptors (CSCRs) and G-protein coupled receptors (GPCRs).  In   the past years, we have shown that the newly identified interactors of these various integral membrane proteins play novel roles in regulating their activity both in vivo and in vitro. In this way, our systematic MYTH approach offers an unbiased systems level view that facilitates the identification of novel drug targets, thereby promising significant contributions to therapeutic research.

 

Lincoln Stein

Lincoln Stein, M,D., Ph.D.

Professor

Address:
OICR, MaRS West Tower,
Suite 510
661 University Ave.,
Toronto, ON, M5G 0A3

Phone #: 416-673-8514


Research:

Network and pathway-based analysis to identify common mechanisms in multiple cancer types and to devise prognostic and predictive signatures
 

Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  Harvard University
M.D.:  Harvard Medical School
B.A.:  Johns Hopkins University
 

Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics


Research Interests:

Stein's research focuses on using network and pathway-based analysis to identify common mechanisms in multiple cancer types and to devise prognostic and predictive signatures to aid in patient management. In addition, his group works on problems relating to the genome structure and function of the nematode Caenorhabditis elegans.

 

Accepting Rotation Students:

Yes

 

Boris Steipe

Boris Steipe, M.D., Ph.D.

Associate Professor

Address:
University of Toronto,
Medical Sciences Building, Rm. 5271
1 King's College Circle,
Toronto, ON M5S 1A8

Phone #: 416-946-7741

Web Sitehttp://biochemistry.utoronto.ca/steipe/


Research:

Patterns in molecular structure: computational methods of pattern discovery
 

Education:

Postdoctoral Fellow: Max-Planck-Institute for Biochemistry, Germany
Ph.D., M.D.:  University of Munich, Germany
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Computational and Systems Biology
     

Research Interests:

I am interested in recurring patterns in molecular structure: the computational methods of pattern discovery, their characterization regarding features, context and distribution,  their association with function in proteins, and their utility for protein engineering and design.

 

Accepting Rotation Students:

No