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Lori Frappier

Lori Frappier, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1633
Toronto, ON, M5G 1M1

Phone #: 416-946-3501

Web Site: http://individual.utoronto.ca/frappierlab/index.html


Research:

How herpesvirus promote viral persistence and oncogenesis


Education:

Postdoctoral Fellow: Cornell University Medical College
Ph.D.: McGill University
B.Sc.: Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

We study how herpesvirus  proteins (particularly Epstein-Barr virus) manipulate nuclear processes to promote viral persistence and contribute to oncogenesis, often using proteomics methods.  We also study how PML nuclear bodies are regulated and disrupted by viral proteins, and the functions of a novel DNA replication protein that we discovered by proteomics.

 

Accepting Rotation Students:

Yes

 

Andrew Fraser

Andrew Fraser, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre
Rm. 1212, 160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-2712

Web Site: http://www.fraserlab.org/


Research:

How variations in genome sequence affect phenotype in C. elegans


Education:

Postdoctoral Fellow: Wellcome/CRC Institute, U.K.
Postdoctoral Fellow: Cold Spring Harbor
Ph.D.:  University of London, U.K.
B.Sc. - University of Cambridge, U.K.


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We want to understand how variations in genome sequence affect phenotype in health and disease. To do this, we use the nematode worm as a simple model system in which we can perturb the function of any gene in any genetic background and learn how to predict the outcome.

 

Accepting Rotation Students:

No

 

Barbara Funnell

Barbara Funnell, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1632
Toronto, ON, M5G 1M1

Phone #: 416-978-1665

Web Site: http://individual.utoronto.ca/funnell_lab/


Research:

Chromosome dynamics, segregation of bacterial plasmids


Education:

Postdoctoral Fellow:  Stanford University
Ph.D.:  University of Wisconsin, Madison
B.Sc.:  McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our interest is chromosome dynamics, in particular, the segregation, or partition, of bacterial plasmids. Plasmids carry genes beneficial to their bacterial hosts but often harmful to us, such as antibiotic resistance and pathogenesis genes. We study the mechanism of partition using the P1 plasmid model system in Escherichia coli.

 

Accepting Rotation Students:

No

 

Brenda Gallie

Brenda Gallie, M.D.

Professor

Address:
Princess Margaret Cancer Centre, Rm. 8-415
610 University Ave.
Toronto, ON, M5G 1L7

Phone #: 416-294-9729

Web Site: http://technainstitute.com/p/gallie/profile/


Research:

Diagnosis, prediction and prevention of heritable cancer


Education:

Postdoctoral Fellow:  University of Toronto
M.D.:  Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

Research Interests

My focus is diagnosis, prediction and prevention of heritable cancer. My research uses molecular genomics to understand the cascade of genomic changes that can be targetted to achieve cost-effective health care, including global clinical trials and guidelines, implemented for all 8000 children per year.

 

Anne-Claude Gingras

Anne-Claude Gingras, Ph.D.

Professor

Address:
Mount Sinai Hospital
LTRI, Rm. 992
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-5027

Web Site: http://gingraslab.lunenfeld.ca/


Research:

Proteomics, biochemistry cell biology phosphoregulation


Education:

Postdoctoral Fellow:  Institute for Systems Biology, Seattle
Ph.D.:  McGill University
B.Sc.:  Université Laval, Ste-Foy


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases whose misregulation may result in numerous diseases, including cancer, diabetes and vascular diseases. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to uncover the basis of phosphoregulation.

 

Accepting Rotation Students:

No

 

Scott Gray-Owen

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Scott Gray-Owen, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Room 4381
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-946-5307


Research:

Pathogen interactions of human-restricted bacterial and viral pathogens


Education:

Postdoctoral Fellow:  Max Planck Insitut für Biologie, Germany
Ph.D.: University of Calgary  
B.Sc.: University of Calgary


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our research aims to understand how human-restricted bacterial pathogens colonize host tissues and evade the host’s otherwise effective immune response. Our paradigm is the pathogenic Neisseria sp., which includes the bacteria that cause the sexually transmitted disease gonorrhea and rapidly progressing invasive meningococcal meningitis. These bacteria are highly adapted to life in humans, undergoing constant evolution of surface antigens via a combination of antigenic and phase variation, and actively suppressing both innate and adaptive immune responses. Our studies in this regard have led to the development of more relevant in vitro and in vivo models of neisserial infection and disease; to a detailed description of molecular processes that occur downstream of immune activating and inhibitory carcinoembryonic antigen-related cellular adhesion molecule (CEACAM)-related proteins; to reveal a previously unrecognized ‘pathogen-associated molecular pattern’ (PAMP) that allows innate immune detection of bacterial in the tissues; to provide new molecular and immunological insights into the epidemiological synergy between sexually transmitted gonorrhea and HIV-1; to the development of novel vaccines with the potential to broadly protect against neisserial infection; and to the development of a new class of antibiotics that function by activating cylindrical proteases within the bacterial cytoplasm. 

 Publications (Pubmed)   

 

Accepting Rotation Students:

No

 

Jack Greenblatt

Jack Greenblatt, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 960
160 College Street
Toronto, ON M5S 3E1

Phone #: 416-978-4141

Web Site: http://sites.utoronto.ca/greenblattlab/


Research:

Protein-protein and protein-RNA interaction networks for chromatin-related proteins and DNA-binding transcription factors


Education:

Postdoctoral Fellow:  Pasteur Institute, Paris
Ph.D.: Harvard University
B.Sc. (Hon): McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Computational and Systems Biology

 

Research Interests:

Our current major aims are using affinity purification/mass spectrometry and second-generation sequencing to establish protein-protein and protein-RNA interaction networks for the approximately 900 human chromatin-related proteins and  >1000 human DNA-binding transcription factors, as well as to identify some of their important functions in transcription and their relationships to human diseases.

 

Accepting Rotation Students:

Yes

 

Sevan Hopyan

Sevan Hopyan, M.D.-Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9713
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301266

Admin: stella.umana@sickkids.ca

Web Site: https://lab.research.sickkids.ca/hopyan/

 


Research:

Morphogenetic mechanisms that shape the limb bud


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Clinical Fellow:  Royal Children's Hospital, Australia
M.D., Ph.D.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

My lab studies morphogenetic mechanisms that shape the initial limb bud and what early molecular events specify skeletal pattern. Our goals are to quantitatively model limb bud growth in 4D, and use what we learn to bioengineer a limb bud in a dish. We also identify mutations that cause human anomalies.

 

Accepting Rotation Students:

No

 

Timothy Hughes

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Timothy Hughes, Ph.D.


Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1302
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-946-8260

Web Site: http://hugheslab.med.utoronto.ca/


Research:

How eukarotic cells recognize and interpret the information in the genome, by studying protein-DNA and protein-RNA sequence specificity


Education:

Postdoctoral Fellow:  Rosetta Inpharmatics (now Merck)
Ph.D.:  Baylor College of Medicine
B.Sc., B. Music:  University of Iowa


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

The genome sequence has been described as a blueprint, but it is one that we are largely unable to read.  Our goal is to understand how eukaryotic cells recognize and interpret the information in the genome, by collecting large-scale data on protein-DNA and protein-RNA sequence specificity.

 

Accepting Rotation Students:

Yes

 

Chi Chung Hui

Chi Chung Hui, D.Sc.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-4994

Admin: katheline.aguilar@sickkids.ca

Web site: http://lab.research.sickkids.ca/hui/

 


Research:

Genetic control of animal development and tumorigenesis


Education:

Postdoctoral Fellow:  National Institute for Basic Biology, Japan
Postdoctoral Fellow: Samuel Lunenfeld Research Institute, Toronto
D.Sc. (Ph.D.): Nagoya University, Japan
M. Phil.: University of Hong Kong
B.Sc. (Hon):   University of Hong Kong


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

We are interested in understanding the genetic control of animal development and the molecular mechanisms involved in tumorigenesis.  We utilize molecular genetic approaches in mice to examine how Gli transcription factors are regulated by Hedgehog-dependent and -independent mechanisms, and the function of Iroquois transcription factors in heart and limb development.

 

Accepting Rotation Students:

Yes

 

Sadhna Joshi

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Sadhna Joshi, D.Sc.

Associate Professor

Address:
Room 4377, Medical Sciences Building
1 King’s College Circle
Toronto, ON M5S 1A8

Phone #: 416-978-2499

Web Site: http://drsadhnajoshi.weebly.com/


Research:

Genetic strategies for HIV-1 prevention


Education:

Postdoctoral Fellow: University of Leiden, The Netherlands
D.Sc., Ph.D.: University of Paris VII, Paris, France
B.Sc.: University Paris VII, Paris, France


Fields of Interest:

Molecular Microbiology and Infectious Disease

 

Research Interests:

Research in my laboratory is focused on the development of genetic strategies for HIV-1 prevention (microflora defense) and treatment (gene therapy). Genes encoding secreted bi- and tri-functional antiviral proteins that inhibit HIV-1 infection of unmodified target cells are used for this purpose.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Monica Justice

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Monica Justice, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 14-9716
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 x309199

Admin: catherine.tan@sickkids.ca

Web Site: http://lab.research.sickkids.ca/justice/


Research:

Mouse Modeling / Clinical Genetics
Additional Affiliations
Head and Senior Scientist, Program in Genetics and Genome Biology, SickKids


Education:

Postdoctoral Fellow: National Cancer Institute - Frederick Cancer Research and Development Center
Ph.D.: Kansas State University
B.Sc.: Fort Hayes State University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

Dr Justice’s research aims to merge mouse modeling with clinical genetics to understand the basis for human diseases, and to exploit models to improve disease symptoms. Two major projects are 1) eliminating tumour-initiating cells in childhood cancers and 2) discovering pathways for therapeutic intervention in Rett Syndrome through genetic suppressors.

 

Accepting Rotation Students:

Yes

 

Ran Kafri

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Ran Kafri, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Reserach & Learning, Room 18-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 x309092

Admin: sandy.hume@sickkids.ca

Web Site: http://www.kafrilab.com/


Research:

Quantitative aspects of cellular identity


Education:

Postdoctoral Fellow: Harvard University
Ph.D.: Weizman Institute of Science
B.Sc.: Ben Gurion University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Computational and Systems Biology

 

Research Interests:

The Kafri lab is interested in how quantitative aspects of cellular identity are specified and regulated. For example, in animals, different types are different in size. How is a cell’s particular size specified?

 

Accepting Rotation Students:

No

 

David Kaplan

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David Kaplan, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 18-9715
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301433

Admin: michelle.driz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/miller-kaplan/

 


Research:

Genes and signaling pathways regulating neurodegeneration and neuronal survival


Education:

Postdoctoral Fellow:  University of California, San Francisco
Ph.D.:  Harvard University
B.A.:  Clark University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

We focus on identifying and characterizing the genes and signaling pathways regulating neurodegeneration and neuronal survival, how stem cells build and repair the brain, on developing drugs to mobilize our stem cells to repair injuries and degeneration, and discovering new drugs to treat brain and childhood cancers.

 

Accepting Rotation Students:

No

 

Lewis Kay

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Lewis Kay, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 1233
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-0741

Web Site: http://abragam.med.utoronto.ca/


Research:

NMR spectroscopy methods for supra-molecular complexes and sparsely populated conformational states of protein


Education:

Postdoctoral Fellow:  National Institutes of Health, Maryland
Ph.D.: Yale University
B.Sc.:  University of Alberta


Fields of Interest:

  • Cellular and Molecular Structure and Function

 

Research Interests:

NMR spectroscopy of supra-molecular complexes including the proteasome, nucleasome and chaperone systems.
NMR spectroscopy of transiently and sparsely populated conformational states of proteins.
Development of NMR spectroscopy methods for the study of protein structure and dynamics.

 

Philip Kim

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Philip Kim, Ph.D.

Associate Professor

Address:
University of Toronto
The Donnelly Centre Rm. 606
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-946-3419

Web Site: http://www.kimlab.org/


Research:

Computational methods to study protein interactions and signaling networks in the context of cancer and other diseases


Education:

Postdoctoral Fellow: Yale University
Ph.D.:  Massachusetts Institute of Technology
Vordiplom/B.S.:  University of Tuebingen


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

The Kim lab uses and develops computational methods to study protein interactions and signaling networks in the context of cancer and other diseases. We use an integrative approach that encompass structural biophysics, systems biology and comparative genomics. Ultimately, we aim to help develop novel therapies.

 

Accepting Rotation Students:

Yes

 

Henry Krause

Henry Krause, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 502
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-8602

Web Site: http://sites.utoronto.ca/krause


Research:

Drosophila and Zebrafish genome-scale approaches to understanding development and disease


Education:

Postdoctoral Fellow:  Biozentrum, Switzerland
Ph.D.: University of Alabama, Birmingham
B.Sc.: McGill University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

Our lab is using live animal (Drosophila and zebrafish), genome-scale approaches to understand developmental and disease processes. We have also developed animal models to screen for new drugs that control diseases such as diabetes, cancer and depression.

 

Accepting Rotation Students:

No

 

Brigitte Lavoie

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Brigitte Lavoie, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1514
Toronto, ON, M5G 1M1

Phone #: 416-978-6123

Web Site: http://individual.utoronto.ca/.../Welcome.html


Research:

Eukaryotic chromosome biology


Education:

Postdoctoral Fellow:  Carnegie Institution of Washington
Postdoctoral Fellow:  University of Geneva
Ph.D.:  University of Western Ontario
B.Sc.: University of Moncton


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Errors in chromosome transmission significantly impact human health.  My group studies two fundamental aspects of eukaryotic chromosome biology:  how newly-replicated sister chromatids are "glued" from S phase until anaphase, and even more mysteriously, how delicate strands of chromatin are packaged into mitotic chromosomes--the iconic units of genome transmission.

 

Accepting Rotation Students:

No

 

Julie Lefebvre

Lefebvre.jpg

Julie Lefebvre, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Center for Research and Learning Rm 59707
686 Bay St.
Toronto ON M5G 0A4

Phone #: 416-813-7654 ext 309248

Web Site: http://www.sickkids.ca/.../julie-lefebvre-staff-profile.html


Research:

Neural Circuit Development


Education:

Postdoctoral Fellowship:  Harvard University, Neurobiology
PhD: University of Pennsylvania, Cell & Molecular Biology
BSc: McGill University, Honours Physiology


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

Our laboratory studies how developing neurons precisely organize into neural circuits.  We study molecular and cellular mechanisms that specify neuronal wiring patterns and partners.  Using transgenic mice, genetic and viral approaches to visualize neurons, and cutting-edge microscopy, we study how these pathways govern the assembly and function of neural circuits in the brain and retina.

 

Accepting Rotation Students:

Yes

 

Howard Lipshitz

Howard Lipshitz, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1538
Toronto, ON M5G 1M1

Phone #: 416-946-5296

Web Site: http://sites.utoronto.ca/flylab


Research:

Post-transcriptional regulation of gene expression in Drosophila with a focus on RNA-binding proteins and small RNAs


Education:

Postdoctoral Fellow:  Stanford University
M.Phil., Ph.D.:  Yale University
B.Sc., B.Sc.(Hon):  University of Natal, Durban, South Africa 


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We study post-transcriptional regulation of gene expression in Drosophila with a focus on RNA-binding proteins and small RNAs that regulate the stability, subcellular localization and translation of maternal mRNAs in early embryos. We use gene-by-gene and genome-wide analyses of the transcriptome, ribonome and proteome.

 

Accepting Rotation Students:

Yes