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3

Charles Boone

Charles Boone, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Room 1312
160 College Street
Toronto, ON M5S 3E1

Phone #: 416-946-7260

Web Site: http://sites.utoronto.ca/boonelab/


Research:

Functional genomics for mapping genetic, chemical-genetic, and protein-protein interactions in yeast


Education:

Postdoctoral Fellow:  University of Oregon
Ph.D.:  McGill University
B.Sc.:  Queen's University


Fields of Interest:

Computational and Systems Biology
Functional Genomics and Proteomics

 

Research Interests:

We are developing and applying functional genomics approaches for mapping genetic, chemical-genetic, and protein-protein interactions on a large-scale using the yeast model system. The ultimate goal is to place all yeast genes and their corresponding products on a functional network.

 

Accepting Rotation Students:

Yes

 

 

 

Gabrielle Boulianne

Gabrielle Boulianne, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8701

Admin: iris.biberstein@sickkids.ca

Web Site: http://sites.utoronto.ca/gboullab/


Research:

Development and function of the nervous system


Education:

Postdoctoral Fellow: University of Calilfornia, San Francisco
Ph.D.: University of Toronto
B.Sc.: McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

 The Boulianne lab uses the fruit fly, Drosophila melanogaster, as a model to study the development and function of the nervous system and to establish models of human disease.

 

Accepting Rotation Students:

No

 

Julie Brill

Julie Brill, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9716, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8863



Web Site:   http://www.sickkids.ca/AboutSickKids/Directory/People/B/Julie-Brill-Staff-Profile.html


Research:

Phosphatidylinositol phosphates in animal development

Education:

Postdoctoral Fellow:  Stanford School of Medicine
Ph.D.: Massachusetts Institute of Technology
B.A.:  Swarthmore College


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

 Phosphatidylinositol phosphates (PIPs) are membrane lipids with critical roles in cell signaling, yet little is known of their functions in animal development. Using Drosophila, we discovered novel roles for PIPs and their regulators in cytokinesis, gametogenesis and organelle biogenesis. Our future studies will uncover molecular mechanisms involved in these processes.

 

Accepting Rotation Students:

No

 

Martha Brown

Martha Brown, Ph.D.

Associate Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 4256
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-5853


Research:

Enteric adenoviruses


Education:

Postdoctoral Fellow: Hospital for Sick Children
Postdoctoral Fellow: Universite de Sherbrooke
M.Sc., Ph.D.: Queen's University
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

The fastidious human enteric adenoviruses are a leading cause of pediatric diarrhea but do not cause disease in other tissues.  Research interests include: the unique structural features of these adenoviruses, how they enter intestinal cells, blocks to replication in other cells and development of these viruses as vaccine vectors.

 

Accepting Rotation Students:

No

 

John Brumell

John Brumell, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 19-9706
686 Bay St.
Toronto, ON, M5G 0A4

Phone #: 416-813-3555

Web Site: http://www.sickkids.ca/...Brumell.html


Research:

How bacterial pathogens infect cells


Education:

Postdoctoral Fellow:  University of British Columbia
Postdoctoral Fellow:  SLRI, Mount Sinai Hospital
Ph.D.:  University of Toronto
B.Sc.:  University of Western Ontario


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

My research examines how bacterial pathogens can infect our cells, and cause disease.

 

Accepting Rotation Students:

Yes

 

 

Amy Caudy

Amy Caudy, Ph.D.

Associate Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 308
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-4074

Web Site: http://tdccbr.med.utoronto.ca/...caudy.html


Research:

Metabolomics, cell growth and metabolism


Education:

Lewis-Sigler Fellow:  Princeton University
Postdoctoral Fellow:  Washington University
Ph.D.:  Watson School of Biological Sciences, Cold Spring Harbor Laboratory
B.A.:  Washington University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Functional Genomics and Proteomics

 

Research Interests:

Discovery of novel enzymatic pathways using full scan LC-MS metabolomics, and characterization of the regulatory connections between cell growth and metabolism.

 

Accepting Rotation Students:

No

 

Brian Ciruna

Ciruna.jpg

Brian Ciruna, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 15-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 302050

Admin: iris.biberstein@sickkids.ca

Web Site: http://www.sickkids.ca/...Brian-Ciruna-Staff-Profile.html


Research:

Zebrafish developmental genetics


Education:

Postdoctoral Fellow: New York University School of Medicine
Ph.D.:  University of Toronto
B.Sc. (Hon): University of Toronto


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Determine how polarized changes in cell shape, structure and movement ultimately form the vertebrate body during embryonic development.
Determine how abnormal cell polarity contributes to congenital malformations and disease (including scoliosis, polycystic kidney disease, and tumor metastasis).
Develop new technologies for zebrafish developmental genetic research.

 

Accepting Rotation Students:

Yes

 

 

Julie Claycomb

Julie Claycomb, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1535
Toronto, ON, M5G 1M1

Phone #: 416-978-3825

Web Site: http://individual.utoronto.ca/claycomblab/


Research:

Small RNA pathways in animal development


Education

Postdoctoral Fellow: University of Massachusetts Medical School
Ph.D.: Massachusetts Institute of Technology
B.Sc. (Hon), B.A.:  University of Pittsburgh


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Research in the Claycomb lab is aimed at uncovering the molecular mechanisms by which small RNA pathways related to RNA interference modulate chromatin throughout animal development. Our studies exploit integrated experimental approaches including molecular genetics, genomics, and cell biology in the model nematode, C. elegans.

 

Accepting Rotation Students:

Yes

 

 

Alan Cochrane

Alan Cochrane, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Room 4383
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-2500


Research:

HIV-1 RNA processing by host factor


Education:

Postdoctoral Fellow: Roche Institute of Molecular Biology
Ph.D.: Queen's University
B.Sc.: McMaster University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

HIV-1 replication is critically dependent upon tight regulation of RNA processing. From a single transcript, over 40 mRNAs are generated. My lab is focused on identify host cellular factors which regulate this process and characterizing small molecules that disrupt it in the hope of developing novel treatments for this disease.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Dr. Cochrane is an active member of the CanCURE research consortium (Canadian HIV Cure Enterprise) 

www.cancurehiv.org          

CanCURE logo_EN_COLOR.jpg

 

 

Ronald Cohn

Ronald Cohn, M.D.

Professor

Address:
Hospital for Sick Children
Div. of Metabolic & Clinical Genetics, Suite 960
525 University Ave.
Toronto ON M5G 1X8

Phone #: 416.813.7654 ext. 228780

Admin: meagan.cameira@sickkids.ca

Web Site: http://www.sickkids.ca/../.Ronald-Cohn.html


Research:

Paediatrics, Genetics, Molecular Biology of Neuromuscular Disorders


Education:

Postdoctoral Fellow:  University of Iowa and Johns Hopkins University
M.D.:  University of Essen, Germany

 

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Maintenance of muscle mass in inherited and acquired muscle disorders
Molecular mechanisms of muscle regeneration and fibrosis
Hypotonia with a particular focus on muscle and connective tissue disorders
Translating next generation sequencing into daily clinical diagnostics and management

 

Accepting Rotation Students:

Yes

 

 

Richard Collins

Richard Collins, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 4280
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-3541

Web Site: http://individual.utoronto.ca/collins_lab/


Research:

RNA and mitochondria


Education:

Postdoctoral Fellow:  St. Louis University
Ph.D.:  University of Regina
B.Sc.:  University of Regina


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

 We are interested in RNA and mitochondria, especially a natually-occurring Neurospora mitochondrial plasmid that encodes a catalytic RNA called the VS ribozyme. We are currently studying how such plasmids move between mitochondria, and whether they may be useful as vectors for genetic transformation of mitochondria.

 

Sabine Cordes

Sabine Cordes, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI. Rm.865
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8891


Research:

Mouse neurodevelopment, neuronal function and angiogenesis


Education:

Postdoctoral Fellow:  Stanford University
Ph.D.:  University of California, Berkeley
B.Sc.:  University of  California, Berkeley


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

We combine mouse genetics with molecular analyses in vitro and other model organisms to understand the molecular mechanisms that govern neurodevelopment, neuronal function and angiogenesis (blood vessel branching). This approach may lead towards new insights and therapies for human disorders of mood and mind, as well as anti-angiogenic therapies.

 

Accepting Rotation Students:

Yes

 

 

Leah Cowen

Leah Cowen, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1638
Toronto, ON, M5G 1M1

Phone # :416-978-4085

Web Site: http://individual.utoronto.ca/cowen/index.html


Research:

Pathogenic fungi in evolution, development, and disease


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  University of Toronto
B.Sc.:  University of British Columbia


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Research in the Cowen lab exploits model and pathogenic fungi to address mechanisms governing evolution, development, drug resistance, and infectious disease.  We take an interdisciplinary approach incorporating genomics, proteomics, chemical genomics, molecular genetics, experimental evolution, and models of fungal pathogenesis.  Our work reveals novel therapeutic strategies for life-threatening infectious disease.

 

Accepting Rotation Students:

Yes

 

 

Joe Culotti

Joe Culotti, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI Rm.846
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8244


Research:

Mechanism of axon guidance and cell migration


Education:

Postdoctoral Fellow: Max Planck Institute for Experimental Medicine
Postdoctoral Fellow: California Institute of Technology
Ph.D.: University of Washington
B.Sc.:  University of California, Irvine


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Our research focuses on the molecular mechanisms of axon growth and guidance as well as the molecular mechanisms of cell migration.

 

Alan Davidson

Alan Davidson, Ph.D

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1634
Toronto, ON, M5G 1M1

Phone #: 416-978-0332

Web Site: http://individual.utoronto.ca/Davidsonlab/index.html


Research:

Bacteriophages and CRISPR systems


Education:

Postdoctoral Fellow: Massachusetts Institute of Technology
Ph.D.: University of Toronto
B.Sc.: University of Toronto


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

My laboratory focuses on bacteriophages (phages), the viruses that infect bacteria.  We study how phages work, and how we can exploit phage-derived entities for applications in human health.  We also study anti-CRISPRs, which are phage-encoded inhibitors of CRISPR-Cas systems. We discovered these proteins, and are currently endeavouring to understand how they work, and how they can be exploited in genome editing applications.

 

Accepting Rotation Students:

Yes

 

 

Paul Delgado Olguin

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 10-9715
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-5080

Web Site: http://www.sickkids.ca/...index.html


Research:

Histone modifiers in cardiovascular development and maintenance


Education:

Postdoctoral Fellow:  University of California, San Francisco
Ph.D.:  National Autonomous University of Mexico
B.Sc. (Hon):  National Autonomous University of Mexico


Fields of Interest:

  • Genetic Models of Development and Disease

  • Functional Genomics and Proteomics

 

Research Interests:

Our laboratory uses in vivo and in vitro approaches to uncover the mechanistic involvement of several histone modifiers in cardiovascular development and maintenance. Our approaches range from analyzing the cardiac and vascular morphology in mutant models, to determining global gene expression profiles and chromatin structure in specific embryonic and adult cell types as well as stem cell differentiation models in order to uncover the cellular and molecular events controlling cardiovascular differentiation, organogenesis and maintenance.

 

Accepting Rotation Students:

No

 

James Dennis

James Dennis, Ph.D.

Professor

Address:
Mount Sinai Hospital
LTRI Rm. 988
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8233

Web Site: http://dennislab.lunenfeld.ca/


Research:

Cell surface receptors and signaling


Education:

Postdoctoral Fellow:  University of Toronto
M.Sc., Ph.D.:  Queens University
B.Sc.:  Concordia University


Fields of Interest:

  • Computational and Systems Biology
  • Genetic Models of Development and Disease

Research Interests:

We study the regulation of cell surface receptors and signaling. Cell surface expression of receptors is dependent on N-glycosylation in the ER and modifications in the Golgi, which is in turn, sensitive to basic metabolism. Models include cell culture, mice and C. elegans, and phenotypes include cancer, immunity and stem cell maintenance.

 

Brent Derry

Brent Derry, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 18-9714
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301829

Admin: michelle.driz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/derry


Research:

Apoptosis and DNA repair in C. elegans


Education:

Postdoctoral Fellow:  University of California, Santa Barbara
Ph.D.: University of California, Santa Barbara
M.Sc.:  Carleton University
B.Sc.:  McMaster University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Functional Genomics and Proteomics

 

Research Interests:

We are interested in cell autonomous and cell-nonautonomous mechanisms of apoptosis and DNA repair in the nematode worm C. elegans. We are also interested in understanding mechanisms by which the cerebral cavernous malformation (CCM) proteins control excretory canal development.

 

Accepting Rotation Students:

Yes

 

John Dick

John Dick, Ph.D.

Professor

Address:
UHN, MaRS Centre
TMDT Bldg., East Tower Rm 8-358
101 College St.
Toronto, ON, M5G 1L7

Phone #: 416-581-7472

Web Site: http://jdstemcellresearch.ca/


Research:

Human hematopoiesis and leukemogenesis


Education:

Postdoctoral Fellow:  OCI & Mt. Sinai Hospital Research Institute
Ph.D.:  University of Manitoba
B.Sc. (Hon):  University of Manitoba


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Understanding human hematopoiesis and leukemogenesis using unique human tissue based models to examine critical genes, proteins, or epigenetic factors in these processes
Pursuing pre-clinical studies of therapeutics and whether they are targeting cancer stem cells
Exploring potential biomarkers that may stratify leukemia patients and advance personalized medicine.

 

Accepting Rotation Students:

No

 

Peter Dirks

Peter Dirks, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-6426

Admin: stella.umana@sickkids.ca

Web Site: http://www.sickkids.ca/Research/Dirks-Lab/index.html


Research:

Stem cells in brain cancer


Education:

Clinical Fellowship: University Rene Descartes, Paris
Ph.D.:  University of Toronto
M.D.: Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

Our laboratory is interested in applying the conceptual and methodologic framework of stem cell biology to the study of brain cancer. In our view, brain cancer is a caricature of normal development but with aberrant molecular regulation of self renewal and differentiation. We study both human brain cancer and mouse models of brain cancer to ask questions about cell of origin, nature of the cells that propagate cancer growth, and explore novel therapeutic targets using genetic and small molecule approaches.

 

Accepting Rotation Students:

Yes