Viewing entries tagged
GP-2

Craig Smibert

Craig Smibert, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1537
Toronto, ON, M5G 1M1

Phone #: 416-946-5538

Web Sitehttp://biochemistry.utoronto.ca/person/craig-a-smibert/

 


Research:

Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation

Education:

Postdoctoral Fellow: Stanford University
Ph.D.:  McMaster University
B.Sc.:  McMaster University
 

Fields of Interest:

  • Functional Genomics and Proteomics
  • Genetic Models of Development and Disease
     

Research Interests:

Post-transcriptional regulation of gene expression is achieved through the control of mRNA translation, mRNA stability and subcellular mRNA localization. Post-transcriptional regulation is mediated by RNA-binding proteins and regulatory RNAs that recognize specific sequences within target transcripts. We use both Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation.

 

Accepting Rotation Students:

Yes

 

Igor Stagljar

Igor Stagljar, Ph.D.

Professor

Address:
University of Toronto,
Donnelly Centre, Rm. 1204
160 College St., Toronto, ON M5S 3E1

Phone #: 416-946-7828

Web Sitehttp://biochemistry.utoronto.ca/stagljar/


Research:

Studies of yeast and human integral membrane proteins in cell signaling and membrane transport at a system level

Education:

Postdoctoral Fellow:  University of Zurich & University of Washington (Seattle)
Ph.D.:  Swiss Federal Institute of Technology (ETH) Zurich, Switzerland
B.Sc.:  University of Zagreb, Croatia
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics
     

Research Interests:

A focus of my lab is to understand the function of the majority of “druggable” yeast and human integral membrane proteins involved in cell signaling and membrane transport at a systems level. Despite extensive research in the past decade, there is a lack of in-depth understanding of protein networks associated with these integral membrane proteins because of their unique biochemical features, enormous complexity and multiplicity. This is a major obstacle for designing improved and more targeted therapies, and importantly, understanding the biology of deregulation of these integral membrane proteins which leads to numerous human diseases.  To address this challenge, we are applying an in vivo genetic system previously developed in my lab, called the membrane yeast two-hybrid (MYTH) assay, to identify and characterize protein interactors of all yeast ABC transporters and human receptor tyrosine kinases (RTKs), as well as selected cancer stem cell receptors (CSCRs) and G-protein coupled receptors (GPCRs).  In   the past years, we have shown that the newly identified interactors of these various integral membrane proteins play novel roles in regulating their activity both in vivo and in vitro. In this way, our systematic MYTH approach offers an unbiased systems level view that facilitates the identification of novel drug targets, thereby promising significant contributions to therapeutic research.

 

Lincoln Stein

Lincoln Stein, M,D., Ph.D.

Professor

Address:
OICR, MaRS West Tower,
Suite 510
661 University Ave.,
Toronto, ON, M5G 0A3

Phone #: 416-673-8514


Research:

Network and pathway-based analysis to identify common mechanisms in multiple cancer types and to devise prognostic and predictive signatures
 

Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  Harvard University
M.D.:  Harvard Medical School
B.A.:  Johns Hopkins University
 

Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics


Research Interests:

Stein's research focuses on using network and pathway-based analysis to identify common mechanisms in multiple cancer types and to devise prognostic and predictive signatures to aid in patient management. In addition, his group works on problems relating to the genome structure and function of the nematode Caenorhabditis elegans.

 

Accepting Rotation Students:

Yes

 

Erin Styles

EbStyles.png

Erin Styles, Ph.D.

Assistant Professor

Address:
Room 7267, Medical Sciences Building
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-4481

Education:

Research Fellow: University of Toronto
Ph.D.: University of Toronto
B.Sc.: University of Guelph and University of Sydney, AU

Research and Teaching:

As the director of the Masters of Heath Sciences program in Medical Genomics, my focus is on designing and implementing a professional masters program that provides practical, actionable training in medical genetics and genomics. My research focuses on course and program assessments of success, including the attainment of learning objectives within individual courses, post-graduate success, and the overall impact of the program on patient health outcomes and the adaptation of genomic medicine at the front lines of care.

 

Accepting Rotation Students:

N/A

 

Mikko Taipale

Mikko Taipale, Ph.D.

assistant PROFESSOR

Address:
University of Toronto
The Donnelly Centre, Rm. 806
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-0812

Web Site:  www.taipalelab.org


RESEARCH:

Protein homeostasis network


EDUCATION:

Postdoctoral Fellow: Whitehead Institute, Cambridge MA
Ph.D.: European Molecular Biology Laboratory, Heidelberg, Germany
M.Sc.: University of Oulu, Finland


FIELDS OF INTEREST:

  • Functional Genomics and Proteomics
  • Cellular & Molecular Structure & Function

RESEARCH INTERESTS:

I am interested in the protein homeostasis network, how it is organized in the cell, how it has diversified during millions of years of evolution, and how it is regulated in health and disease. My laboratory also develops functional proteomics methods for investigating challenging biomolecular interactions, such as drug/target and ligand/receptor interactions.

 

Accepting Rotation Students:

Yes

 

Michael Wilson

Michael Wilson, Ph.D.

Associate Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for Research & Learning,
Rm. 14-9713,
686 Bay St., Toronto,
ON M5G 0A4

Phone #: (416) 813-7654 ext. 328699

Admin: catherine.tan@sickkids.ca

Web Site: http://www.wilsonlab.org/


Research:

Comparative genome biology, epigenetics and evolution of regulatory networks

Education:

Postdoctoral Fellow:  University of Cambridge, U.K.
Postoctoral Fellow: University of Victoria, B.C.
Ph.D.:  University of Victoria
B.Sc.:  University of Victoria
 

Fields of Interest

  • Computational and Systems Biology
  • Functional Genomics and Proteomics
     

Research Interests:

  • Comparative genome biology, Functional genomics,  Bioinformatics,  Developmental biology    
  • Characterizing the role that regulatory DNA sequence plays in childhood diseases using comparative genomics, bioinformatics and developmental biology.
  • Epigenetics and evolution of regulatory networks in postnatal germ cells.
  • Modeling of human genome innovations.

 

Accepting Rotation Students:

Yes

 

Jeff Wrana

Jeff Wrana, Ph.D.

Professor

Address:
Mount Sinai Hospital,
LTRI Rm.1070
600 University Ave.,
Toronto, ON, M5G 1X5

Phone #: 416-586-4800

Web Sitehttp://sites.utoronto.ca/attisano


Research:

Signalling pathways integration into higher order networks that control development cancer initiation and progression

Education:

Postdoctoral Fellow: Memorial Sloan Kettering Cancer Center, NY
Ph.D.:  University of Toronto
B.Sc.:  University of Toronto
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics
     

Research Interests:

We seek to understand how signalling pathways are integrated into higher order networks that control morphogenesis in development and which are aberrantly organized during cancer initiation and progression.

 

Accepting Rotation Students:

Yes

 

Ryan Yuen

Yuen, Ryan_Photo_8Aug2018.jpg

Ryan Yuen, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 13.9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301022

Admin: Darvy.Teav@sickkids.ca

 


EDUCATION:

Postdoctoral Fellow: The Hospital for Sick Children
Ph.D.: University of British Columbia
M.Phil.: Chinese University of Hong Kong                                                                                           B.Sc.: Hong Kong University of Science and Technology


FIELDS OF INTEREST:

  • Molecular Medicine & Human Genetics

  • Functional Genomics & Proteomics

 

RESEARCH INTERESTS:

We are interested in understanding how genetic and epigenetic variations contribute to human health, with a focus on neurodevelopmental and neurological disorders. Utilizing (epi)genomic technologies, we aim to develop novel disease gene discovery strategies, effective diagnostic approaches and better treatments for the disorders.

 

Accepting Rotation Students:

Contact PI directly for more information.