Viewing entries tagged
HG-1

Irene Andrulis

Irene Andrulis, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI, Room 984
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8256

Web Site: http://www.lunenfeld.ca/researchers/Andrulis


Research:

Genetic alterations in breast cancer and sarcoma


Education:

Postdoctoral Fellow:  University of Toronto
Ph.D.:  University of California, Irvine
B.Sc.:  University of Pennsylvania


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory conducts multi-disciplinary studies to identify genetic alterations that play a role in breast cancer and sarcoma and to determine their clinical importance.  Our goals are to explore the biology of these genetic alterations, to aid in diagnosis and treatment, and to discover novel targets for therapeutics.

 

Accepting Rotation Students:

No

 

Philip Awadalla

Philip Awadalla, Ph.D.

Professor

Address:
Ontario Institute for Cancer Research
MaRS Centre, Suite 6-42
661 University Ave.
Toronto, ON, M5G 0A3

Phone #: 647-260-7990

Web Site: http://pawadallalab.org

 


Research:

Organization and evolution of biological systems


Education:

Postdoctoral Fellow:  University of British Columbia and University of California, Davis
Ph.D.: University of Edinburgh
M.Sc.: University of Toronto


Fields of Interest:

  • Molecular Medicine and Human Genetics
  • Computational and Systems Biology

 

Research Interests:

Working with empirical genomic data and modern computational models, the laboratory addresses questions relevant to how genetics and the environment influences the frequency and severity of diseases in human populations. Our work focuses on next generation genomic tools to capture genetic determinants of phenotypes, specifically associated with aging, cancer and infectious diseases, from large population cohorts as well as family based studies.

 

Accepting Rotation Students:

Yes

 

 

Alan Bernstein

Alan Bernstein

Adjunct Professor

Address:
Canadian Institute for Advanced Research, Suite 505
MaRS West Tower, 661 University Ave.
Toronto, ON M5G 1M1

Phone #: 416-971-4255

Web Site: http://www.cifar.ca/cifar-staff


Research:

Intersection of research and public policy, especially science policy


Education

Postdoctoral Fellow:  Imperial Cancer Research Laboratories, U.K.
M.Sc, Ph.D.:  University of Toronto
B.Sc.:  University of Waterloo


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

My current research interests centre around the intersection of research and public policy, especially with regard to science policy.

 

 

Ronald Cohn

Ronald Cohn, M.D.

Professor

Address:
Hospital for Sick Children
Div. of Metabolic & Clinical Genetics, Suite 960
525 University Ave.
Toronto ON M5G 1X8

Phone #: 416.813.7654 ext. 228780

Admin: meagan.cameira@sickkids.ca

Web Site: http://www.sickkids.ca/../.Ronald-Cohn.html


Research:

Paediatrics, Genetics, Molecular Biology of Neuromuscular Disorders


Education:

Postdoctoral Fellow:  University of Iowa and Johns Hopkins University
M.D.:  University of Essen, Germany

 

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Maintenance of muscle mass in inherited and acquired muscle disorders
Molecular mechanisms of muscle regeneration and fibrosis
Hypotonia with a particular focus on muscle and connective tissue disorders
Translating next generation sequencing into daily clinical diagnostics and management

 

Accepting Rotation Students:

Yes

 

 

John Dick

John Dick, Ph.D.

Professor

Address:
UHN, MaRS Centre
TMDT Bldg., East Tower Rm 8-358
101 College St.
Toronto, ON, M5G 1L7

Phone #: 416-581-7472

Web Site: http://jdstemcellresearch.ca/


Research:

Human hematopoiesis and leukemogenesis


Education:

Postdoctoral Fellow:  OCI & Mt. Sinai Hospital Research Institute
Ph.D.:  University of Manitoba
B.Sc. (Hon):  University of Manitoba


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Understanding human hematopoiesis and leukemogenesis using unique human tissue based models to examine critical genes, proteins, or epigenetic factors in these processes
Pursuing pre-clinical studies of therapeutics and whether they are targeting cancer stem cells
Exploring potential biomarkers that may stratify leukemia patients and advance personalized medicine.

 

Accepting Rotation Students:

No

 

Peter Dirks

Peter Dirks, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-6426

Admin: stella.umana@sickkids.ca

Web Site: http://www.sickkids.ca/Research/Dirks-Lab/index.html


Research:

Stem cells in brain cancer


Education:

Clinical Fellowship: University Rene Descartes, Paris
Ph.D.:  University of Toronto
M.D.: Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

Our laboratory is interested in applying the conceptual and methodologic framework of stem cell biology to the study of brain cancer. In our view, brain cancer is a caricature of normal development but with aberrant molecular regulation of self renewal and differentiation. We study both human brain cancer and mouse models of brain cancer to ask questions about cell of origin, nature of the cells that propagate cancer growth, and explore novel therapeutic targets using genetic and small molecule approaches.

 

Accepting Rotation Students:

Yes

 

James Dowling

James Dowling, M.D., Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, 15-9703
686 Bay St.
Toronto ON M5G 0A4

Phone #: 416-813-8980 (x308980)

Admin: irina.iovu@sickkids.ca

Website:

http://www.sickkids.ca/AboutSickKids/Directory/People/D/James-Dowling-Staff-Profile.html


Research:

diseases of skeletal muscle, phosphoinositide signalling, zebrafish


Education:

Postdoctoral Fellow:  University of Michigan
M.D., Ph.D.:  University of Chicago;   Residency: Children's Hospital of Philadelphia
B.Sc., M.Sc.:  Yale University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory seeks to understand the pathogenic mechanisms of and develop therapies for childhood muscle diseases.  We combine gene discovery and model systems research to define disease pathology and identify treatments.  Our favorite model system is the zebrafish, and we are interested in the role of endolysosomes in muscle biology.

 

Accepting Rotation Students:

Yes

 

Aled Edwards

Aled Edwards, Ph.D.

Professor

Address:
Structural Genome Consortium
MaRS South Tower Rm. 701 
101 College St.
Toronto, ON, M5G 1L5

Phone #:416-946-0237

Web Site: http://www.thesgc.org/about/director


Research:

Developing open access research tools (chemical inhibitors, protein structures and recombinant antibodies)
Additional Affiliations
Structural Genomics Consortium

*currently on leave from Dept. of Molecular Genetics while serving as Director of SGC


Education:

Postdoctoral Fellow: Stanford University
Ph.D.: McGill University
B.Sc.: McGill University


Fields of Interest:

  • Functional Genomics and Proteomics

  • Molecular Medicine and Human Genetics

Research Interests:

Developing open access research tools (chemical inhibitors, protein structures and recombinant antibodies) to increase knowledge of human biology and accelerate drug discovery

 

Jessica Hill

Jessica Hill, Ph.D.

Assistant Professor

Address:
Room 7253, Medical Sciences Building
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-4707


Education:

Research Fellow: Hospital for Sick Children
Ph.D.: University of Toronto
M.Sc.: University of British Columbia

Research and Teaching:

I am the course coordinator and a lecturer for the online course MGY250, Introduction to Medical Genetics. I am also involved with the online course MGY277, Introduction to Medical Microbiology. 

My research is focused on improving online education in medical genetics and microbiology. In particular, I am interested in evaluating the effectiveness of online educational tools, improving student engagement in online courses and adapting modules for teaching medical genetics and microbiology in various settings.

 

Sevan Hopyan

Sevan Hopyan, M.D.-Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9713
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301266

Admin: stella.umana@sickkids.ca

Web Site: https://lab.research.sickkids.ca/hopyan/

 


Research:

Morphogenetic mechanisms that shape the limb bud


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Clinical Fellow:  Royal Children's Hospital, Australia
M.D., Ph.D.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

My lab studies morphogenetic mechanisms that shape the initial limb bud and what early molecular events specify skeletal pattern. Our goals are to quantitatively model limb bud growth in 4D, and use what we learn to bioengineer a limb bud in a dish. We also identify mutations that cause human anomalies.

 

Accepting Rotation Students:

No

 

Monica Justice

Justice.jpg

Monica Justice, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 14-9716
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 x309199

Admin: catherine.tan@sickkids.ca

Web Site: http://lab.research.sickkids.ca/justice/


Research:

Mouse Modeling / Clinical Genetics
Additional Affiliations
Head and Senior Scientist, Program in Genetics and Genome Biology, SickKids


Education:

Postdoctoral Fellow: National Cancer Institute - Frederick Cancer Research and Development Center
Ph.D.: Kansas State University
B.Sc.: Fort Hayes State University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

Dr Justice’s research aims to merge mouse modeling with clinical genetics to understand the basis for human diseases, and to exploit models to improve disease symptoms. Two major projects are 1) eliminating tumour-initiating cells in childhood cancers and 2) discovering pathways for therapeutic intervention in Rett Syndrome through genetic suppressors.

 

Accepting Rotation Students:

Yes

 

Philipp Maass

Philipp_Maass.png

Philipp Maass, Ph.D

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 14-9715
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 x302181

Admin: Meghan.Bradley@sickkids.ca

Web site: https://lab.research.sickkids.ca/maass/


Education:

Postdoctoral Fellow:  Harvard University
Postdoctoral Fellow: Max Delbrück Center for Molecular Medicine
Ph.D.: Humboldt University Berlin, Max Delbrück Center for Molecular Medicine
Diploma in Biology, Eberhard Karls University Tübingen, Germany


Fields of Interest:

  • Molecular Medicine & Human Genetics

  • Genetic Models of Development and Disease

 

Research Interests:

Inter-chromosomal interactions between different chromosomes drive gene regulation, but their molecular mechanisms remain elusive. To better understand biology and etiology of disease, the Maass lab focuses on inter-chromosomal interactions, especially of the noncoding genome, that impact development and disease mechanisms in a bedside-to-bench approach.

 

Accepting Rotation Students:

Yes

Lucy Osborne

Osborne.jpg

Lucy Osborne, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1515
Toronto, ON, M5G 1M1

Phone #: 416-946-5804

Web Site: http://individual.utoronto.ca/osbornelab/


Research:

Mouse models and the genetic analysis of human subjects to probe the molecular basis of neurodevelopmental disorders


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Ph.D.:  National Heart & Lung Institute, U.K.
M.Sc.: University College London, U.K.
B.Sc. (Hon): City of London Polytechnic, U.K. 


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Both deletion and duplication of human chromosome 7q11.23 cause neurodevelopmental disorders with unique phenotypic profiles, so offering a window into the genetics of human behavior, cognition and language. We use mouse models and the genetic analysis of human subjects to probe the underlying molecular basis of these disorders.

 

Accepting Rotation Students:

No

 

 

Jeehye Park

Jeehye Park, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning,            Rm 14.9702
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7670

Admin: irina.iovu@sickkids.ca

Web Site: http://www.sickkids.ca/Research/Genetics-and-genome-biology/who-we-are/index.html


Research:

Molecular mechanisms underlying neurodegenerative diseases


Education:

Postdoctoral fellow: Baylor College of Medicine & Howard Hughes Medical Institute  
Ph.D.: Korea Advanced Institute of Science and Technology  
B.S.: Korea Advanced Institute of Science and Technology


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Our laboratory is interested in understanding the molecular mechanisms underlying neurodegenerative diseases with the aim of identifying targetable pathways for therapeutic interventions. Our studies utilize multidisciplinary approaches including biochemistry, molecular cell biology, and Drosophila and mouse genetics.

 

Accepting Rotation Students:

Yes

 

Bret Pearson

Bret Pearson, Ph.D.

Associate Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for Research &
Learning, Rm. 18-9713, 686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 328370

Admin: meera.kamal@sickkids.ca

Web Site: 

http://lab.research.sickkids.ca/pearson/

 

 


Research:

Planarian as an in vivo model system to study stem cells and regeneration

Education:

Postdoctoral Fellow:  University of Utah    
Ph.D.:  University of Oregon
B.S.:  University of Wisconsin, Madison
 

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics


Research Interests:

We focus on how adult stem cells make a correct cell lineage in space and time to replace the exact number of cells lost to tissue turnover or injury. To this end, my lab uses the freshwater planarian as an in vivo model system to study stem cells and regeneration.

 

Accepting Rotation Students:

Yes

 

Christopher Pearson

Christopher Pearson, Ph.D.

Professor

Address:
Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Rm. 14-9714, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8256

Admin: Irina.Iovu@sickkids.ca

Web Site: http://www.cepearsonlab.com/


Research:

DNA repeat instability


Education:

Postdoctoral Fellow:  Texas Medical Center
Ph.D.:  McGill University
B.Sc. (Hon):  Concordia University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

Understand DNA repeat instability; the cause of >40 diseases including Huntington's disease, muscular dystrophy & amyotrophic lateral sclerosis.
Use molecular, stem cell, transgenic mouse models and human tissues to understand and modulate this mutation for clinical benefit.
Focus on DNA repair, replication & epigenetics.
Identify therapeutic targets and preclinical therapeutic drugs.

 

Accepting Rotation Students:

Yes

 

Johanna Rommens

Johanna Rommens, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 14-9712
686 Bay St., 
Toronto, ON M5G 0A4

Phone #: 416-813-7095

Web Site: http://www.sickkids.ca/...Rommens.html 


Research:

Human genetic diseases of the exocrine pancreas, including cystic fibrosis and Schwachman-Diamond syndrome


Education:

Postdoctoral Fellow:  The Hospital for Sick Children, Toronto
Ph.D.:  University of New Brunswick
B.Sc. (Hon): University of New Brunswick


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory is interested in human genetic diseases of the exocrine pancreas, including cystic fibrosis and Shwachman-Diamond syndrome.  We use population studies and mouse models to investigate the mechanisms underlying development and presentation of exocrine pancreatic failure.

 

Accepting Rotation Students:

No

 

Frederick Roth

Frederick Roth, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 912
160 College St. Toronto, ON
M5S 3E1

Phone #: 416-946-5130

Website: http://llama.mshri.on.ca/


Research:

Developing experimental and computational technology to more relate genes and proteins to the functioning of living systems and human disease


Education:

Ph.D.:  Harvard University
B.A.:  University of California, Berkeley


Fields of Interest:

  • Computational and Systems Biology

  • Molecular Medicine and Human Genetics


Research Interests:

Roth's group is focused on developing experimental and computational technology to more efficiently relate genes and proteins to each other and to the functioning of living systems and human disease.

 

Accepting Rotation Students:

Yes

 

Peter Roy

Peter Roy, Ph.D.

Professor

Address:
University of Toronto,
The Donnelly Centre, Rm. 1202
160 College St.,
Toronto, ON, M5S 3E1

Phone #: 416-946-8395

Web Sitehttp://roylab.ccbr.utoronto.ca

 


Education:

Posdoctoral Fellow:  Stanford University
Ph.D.:  University of Toronto
B.Sc.:  Dalhousie University

 

Fields of Interest:

  • Molecular Medicine and Human Genetics

  • Genetic Models of Development and Disease

 

Research:

The Roy Lab is exploiting the nematode worm C. elegans to identify new small molecule tools for animal research and drug development.  Projects in the Roy Lab include the development of compounds to kill parasitic nematodes that infect over 2 billion humans, as well as those nematode parasites that result in billions of dollars of lost productivity in agriculture.  En route towards the development of new drug leads, the Roy Lab works to better understand how animals protect themselves against exogenous small molecules.

 

Accepting Rotation Students:

Yes

 

Stephen Scherer

Stephen Scherer, Ph.D.

 

Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for
Research & Learning,
Rm. 13-9705,
686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7613

Admin:  elainec.chang@sickkids.ca

Web Sitehttp://www.tcag.ca/scherer/


Research:

Human genome structure and function, genomic of neurodevelopmental disorders
 

Education:

M.Sc., Ph.D.:  University of Toronto
B.Sc. (Hon):  University of Waterloo
 

Fields of Interest:

  • Computational and Systems Biology

  • Molecular Medicine and Human Genetics

Research Interests:

Human genome structure and function, genomics of autism and other neurodevelopmental disorders

 

Accepting Rotation Students:

No