Viewing entries tagged
MDD-2

Freda Miller

Freda Miller, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 18-9716
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301434

Admin: michelle.driz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/miller-kaplan/

 


Research:

Cellular mechanisms that regulate development of the mammalian nervous system


Education:

Postdoctoral Fellow:  Scripps Research Institute
Ph.D.:  University of Calgary
B.Sc.:  University of Saskatchewan


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

My laboratory is interested in the cellular mechanisms that regulate development of the mammalian nervous system, with a particular interest in stem cells and trophic factors.

 

Accepting Rotation Students:

No

 

Jason Moffat

Jason Moffat, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 802
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-0336

Web Site: http://moffatlab.ccbr.utoronto.ca/


Research:

Genetic interaction networks in cancer cells.


Education:

Postdoctal Fellow:  Massachusetts Institute of Technology
Ph.D.:  University of Toronto
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Functional Genomics and Proteomics

 

Research Interests:

The Moffat lab is interested in cancer and genetic interaction networks in cancer cells.

 

Accepting Rotation Students:

Yes

 

Julien Muffat

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Julien Muffat, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 17-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 309997

Admin: julie.meltzer@sickkids.ca

Web Site: http://www.sickkids.ca/AboutSickKids/Directory/People/M/julien-muffat.html


Education:

Postdoctoral Fellow: Whitehead Institute for Biomedical Research, MIT
Ph.D.: California Institute of Technology
M.Sc., B.Sc: Université de Paris

Fields of Interest:

  • Genetic Models of Development & Disease

  • Cellular & Molecular Structure & Function

 

Research Interests:

I develop novel 3D cultures derived from human iPSCs to study degenerative diseases of the brain. I focus on neuro-immune aetiologies of diseases ranging from autism to Alzheimer's, highlighting the role of microglia in establishing neuronal dysfunction. CRISPR/Cas9 genome engineering allows functional interrogation of disease-associated variants expressed exclusively in microglia.

 

Accepting Rotation Students:

Yes

Kenichi Okamoto

Kenichi Okamoto, Ph.D.

Assistant Professor

Address:
Mount Sinai Hospital
LTRI Rm.884
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 ext.4936

Web Site: http://www.lunenfeld.ca/researchers/okamoto


Research:

Developing novel technologies to visualize and manipulate protein function in the brain


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  Osaka University, Japan
M.A.:  Toyama University, Japan
B.S.:  Toyama University, Japan


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Elucidating the mechanisms of learning and memory is essential for understanding brain diseases such as Alzheimer’s disease and Autism. We aim to dissect the complex signaling cascades for learning & memory and related brain diseases by developing novel technologies to visualize and manipulate protein function in the brain.

 

Accepting Rotation Students:

Yes

 

Lucy Osborne

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Lucy Osborne, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1515
Toronto, ON, M5G 1M1

Phone #: 416-946-5804

Web Site: http://individual.utoronto.ca/osbornelab/


Research:

Mouse models and the genetic analysis of human subjects to probe the molecular basis of neurodevelopmental disorders


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Ph.D.:  National Heart & Lung Institute, U.K.
M.Sc.: University College London, U.K.
B.Sc. (Hon): City of London Polytechnic, U.K. 


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Both deletion and duplication of human chromosome 7q11.23 cause neurodevelopmental disorders with unique phenotypic profiles, so offering a window into the genetics of human behavior, cognition and language. We use mouse models and the genetic analysis of human subjects to probe the underlying molecular basis of these disorders.

 

Accepting Rotation Students:

No

 

 

Jeehye Park

Jeehye Park, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning,            Rm 14.9702
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7670

Admin: irina.iovu@sickkids.ca

Web Site: http://www.sickkids.ca/Research/Genetics-and-genome-biology/who-we-are/index.html


Research:

Molecular mechanisms underlying neurodegenerative diseases


Education:

Postdoctoral fellow: Baylor College of Medicine & Howard Hughes Medical Institute  
Ph.D.: Korea Advanced Institute of Science and Technology  
B.S.: Korea Advanced Institute of Science and Technology


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Our laboratory is interested in understanding the molecular mechanisms underlying neurodegenerative diseases with the aim of identifying targetable pathways for therapeutic interventions. Our studies utilize multidisciplinary approaches including biochemistry, molecular cell biology, and Drosophila and mouse genetics.

 

Accepting Rotation Students:

Yes

 

Bret Pearson

Bret Pearson, Ph.D.

Associate Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for Research &
Learning, Rm. 18-9713, 686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 328370

Admin: meera.kamal@sickkids.ca

Web Site: 

http://lab.research.sickkids.ca/pearson/

 

 


Research:

Planarian as an in vivo model system to study stem cells and regeneration

Education:

Postdoctoral Fellow:  University of Utah    
Ph.D.:  University of Oregon
B.S.:  University of Wisconsin, Madison
 

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics


Research Interests:

We focus on how adult stem cells make a correct cell lineage in space and time to replace the exact number of cells lost to tissue turnover or injury. To this end, my lab uses the freshwater planarian as an in vivo model system to study stem cells and regeneration.

 

Accepting Rotation Students:

Yes

 

Christopher Pearson

Christopher Pearson, Ph.D.

Professor

Address:
Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Rm. 14-9714, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8256

Admin: Irina.Iovu@sickkids.ca

Web Site: http://www.cepearsonlab.com/


Research:

DNA repeat instability


Education:

Postdoctoral Fellow:  Texas Medical Center
Ph.D.:  McGill University
B.Sc. (Hon):  Concordia University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

Understand DNA repeat instability; the cause of >40 diseases including Huntington's disease, muscular dystrophy & amyotrophic lateral sclerosis.
Use molecular, stem cell, transgenic mouse models and human tissues to understand and modulate this mutation for clinical benefit.
Focus on DNA repair, replication & epigenetics.
Identify therapeutic targets and preclinical therapeutic drugs.

 

Accepting Rotation Students:

Yes

 

Stephanie Protze

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Stephanie Protze, Ph.D.

Assistant Professor

Address:
McEwen Institute, University Health Network
PMCRT 3-918
101 College St.
Toronto, ON, M5G 1L7

Phone #: 416-634-8179

Web Site: https://www.uhnresearch.ca/researcher/stephanie-protze


Education:

Postdoctoral Fellowship:  McEwen Centre, University Health Network, Toronto
PhD: Dresden University of Technology, Germany
B.Sc: Dresden University of Technology, Germany


Fields of Interest:

  • Genetic Models of Development and Disease
  • Cellular and Molecular Structure and Function

 

Research Interests:

We are studying human heart development and disease using the human pluripotent stem cell model system. To facilitate that, my lab has specialized in developmental biology-based differentiation strategies. Our current research focuses on cardiac pacemaker cells and their application for in vitro disease modeling and cell therapies as biological pacemaker.

 

Accepting Rotation Students:

Yes

Miguel Ramalho-Santos

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Miguel Ramalho-Santos, Ph.D.

Professor

Address:
Lunenfeld-Tannenbaum Research Institute
Room 6-1016-2
25 Orde St.
Toronto, ON, M5T 3H7

Phone #: 416-586-4800 x8377

Web Site: https://www.mrsantoslab.org


Education/Professional:

Faculty member:  University of California, San Francisco
Ph.D. & Postdoc:  Harvard University
M.Sc.: University of Coimbra, Portugal


Fields of Interest:

  • Genetic Models of Development & Disease

  • Cellular & Molecular Structure & Function

 

Research Interests:

Our lab is interested in understanding the epigenetic regulation of mammalian development and reproduction. Work from our lab highlights that such foundational aspects as genome organization, transcription and environmental input are regulated in unique ways in pluripotent stem cells of the early embryo and the germline.

 

Accepting Rotation Students:

Yes

Johanna Rommens

Johanna Rommens, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 14-9712
686 Bay St., 
Toronto, ON M5G 0A4

Phone #: 416-813-7095

Web Site: http://www.sickkids.ca/...Rommens.html 


Research:

Human genetic diseases of the exocrine pancreas, including cystic fibrosis and Schwachman-Diamond syndrome


Education:

Postdoctoral Fellow:  The Hospital for Sick Children, Toronto
Ph.D.:  University of New Brunswick
B.Sc. (Hon): University of New Brunswick


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

My laboratory is interested in human genetic diseases of the exocrine pancreas, including cystic fibrosis and Shwachman-Diamond syndrome.  We use population studies and mouse models to investigate the mechanisms underlying development and presentation of exocrine pancreatic failure.

 

Accepting Rotation Students:

No

 

Janet Rossant

Janet Rossant, Ph.D.

Professor

Address:
Hospital for Sick Children, PGCRL Rm. 16.9705
686 Bay St.
Toronto, ON, M5G 0A4

Phone #: 416-813-7929

Admin: katheline.aguilar@sickkids.ca

Web Site: http://lab.research.sickkids.ca/rossant/


Research:

Mechanisms of cell fate decisions in the early mouse embryo and embryo-derived stem cells


Education:

Postdoctoral Fellow:  Oxford University
Ph.D.:  Cambridge University
B.A. (Hon), M.A.:  Oxford University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

The Rossant lab is interested in mechanisms of cell fate decisions in the early mouse embryo and their application to the maintenance and differentiation of embryo-derived stem cells.

 

Accepting Rotation Students:

No

 

Peter Roy

Peter Roy, Ph.D.

Professor

Address:
University of Toronto,
The Donnelly Centre, Rm. 1202
160 College St.,
Toronto, ON, M5S 3E1

Phone #: 416-946-8395

Web Sitehttp://roylab.ccbr.utoronto.ca

 


Education:

Posdoctoral Fellow:  Stanford University
Ph.D.:  University of Toronto
B.Sc.:  Dalhousie University

 

Fields of Interest:

  • Molecular Medicine and Human Genetics

  • Genetic Models of Development and Disease

 

Research:

The Roy Lab is exploiting the nematode worm C. elegans to identify new small molecule tools for animal research and drug development.  Projects in the Roy Lab include the development of compounds to kill parasitic nematodes that infect over 2 billion humans, as well as those nematode parasites that result in billions of dollars of lost productivity in agriculture.  En route towards the development of new drug leads, the Roy Lab works to better understand how animals protect themselves against exogenous small molecules.

 

Accepting Rotation Students:

Yes

 

Daniel Schramek

Daniel Schramek, Ph.D.

Assistant Professor

Address:
Mt. Sinai Hospital
LTRI Room 1084
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-8262

Web Site: http://www.lunenfeld.ca/researchers/schramek


Research:

Regulation of epithelial growth in cancer and inflammation


Education:

Postdoctoral Fellow:  The Rockefeller University & Howard Hughes Medical Institute
Ph.D.:  University of Vienna
M.Sc.: New York University; University of Vienna


Fields of Interest:

  • Functional Genomics & Proteomics
  • Genetic Models of Development & Disease

 

Research Interests:

Our goal is to find novel therapies to combat the most devastating malignancies. We therefore developed direct in vivo gene-editing tools to integrate human cancer genomics and mouse modeling to simultaneously interrogate the tumorigenic and metastatic capabilities of hundreds of putative cancer genes and systematically screen for genotype-specific cancer vulnerabilities.

 

Accepting Rotation Students:

No

 

Ian Scott

Ian Scott, Ph.D.

Professor

Address:

Hospital for Sick Children,
Peter Gilgan Centre for Research
& Learning, Rm. 16.9707
686 Bay St., Toronto,
ON, M5G 0A4

Phone #: 416 813-7654 ext 301572

Admin: katheline.aguilar@sickkids.ca

Web Sitehttp://www.sickkids.ca/AboutSickKids/Directory/People/S/Ian-C-Scott.html


Research:

Cardiovascular development and heart regeneration in zebrafish
 

Education:

Postdoctoral Fellow: University of California, San Francisco
Ph.D.:  University of Toronto
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

Research Interests:

Analysis of cardiovascular development and heart regeneration using the zebrafish model.  We are interested in uncovering the molecular and cellular events that govern embryonic heart development and adult heart regeneration, and applying these discoveries to methods to repair the damaged human heart.

 

Accepting Rotation Students:

Yes

 

Craig Smibert

Craig Smibert, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1537
Toronto, ON, M5G 1M1

Phone #: 416-946-5538

Web Sitehttp://biochemistry.utoronto.ca/person/craig-a-smibert/

 


Research:

Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation

Education:

Postdoctoral Fellow: Stanford University
Ph.D.:  McMaster University
B.Sc.:  McMaster University
 

Fields of Interest:

  • Functional Genomics and Proteomics
  • Genetic Models of Development and Disease
     

Research Interests:

Post-transcriptional regulation of gene expression is achieved through the control of mRNA translation, mRNA stability and subcellular mRNA localization. Post-transcriptional regulation is mediated by RNA-binding proteins and regulatory RNAs that recognize specific sequences within target transcripts. We use both Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation.

 

Accepting Rotation Students:

Yes

 

Neal Sondheimer

neal sondheimer - small (2).png

Neal Sondheimer, M.D.,Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 12-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301480

Admin: denese.henry@sickkids.ca

Web Site: https://tinyurl.com/y9jzjmq6

 


Research:

My Research focuses on the regulation of mitochondrial gene expression and the impact of
mitochondrial mutations in common and rare disease.


Education:

Postdoctoral Fellow:  University of Pennsylvania (Genetics)
M.D., Ph.D.:  University of Chicago
B.A.: Harvard College (Biology)


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

Research Interests:

Mitochondrial DNA variants act as either a low penetrance risk factor for common disorders or as a high penetrance cause of frank mitochondrial failure. In the lab, we study how mitochondrial variants interact with each other and with the nuclear genome to impact organellar function.

 

Accepting Rotation Students:

Yes

 

Derek van der Kooy

Derek van der Kooy, Ph.D.

Professor

Address:
University of Toronto, The Donnelly Centre, Rm. 1102
160 College St., Toronto, ON M5S 3E1

Phone #: 416-978-1960

Web Site: http://sites.utoronto.ca/neurobiology/

 


Research:

Stem cell and developmental biology

Education:

Postdoctoral Fellow:  Cambridge University, U.K.
Postdoctoral Fellow:  Salk Institute
Ph.D.:  University of Toronto
M.A.:  University of British Columbia
 

Fields of Interest

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease
     

Research Interests

The van der Kooy lab works on various stem cell biology and developmental biology research projects; specifically, stem cells in organisms from Drosophila to humans. We produced the first report of stem cells in the adult mammalian eye, published in 2000 in Science. We have also isolated a rare stem cell from the adult mouse and human pancreas that can show extensive proliferation under defined conditions in vitro. Of interest to the lab is the lineage of neural stem cells from pluripotent embryonic stem cells, with relevance to the origin of the earliest neural stem cell in the developing embryo.

 

Accepting Rotation Students:

Yes

 

Andrew Wilde

Andrew Wilde, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1516
Toronto, ON, M5G 1M1

Phone #: 416-946-7714

Websitehttp://individual.utoronto.ca/wildelab


Research:

Biochemical, genetic and live imaging approaches in frogs, flies and tissue culture systems to address fundamental questions in cell division

Education:

Postdoctoral Fellow:  Carnegie Institution of Washington
Postdoctoral Fellow:  University of California, San Francisco
Ph.D.:  University of Bristol, U.K.
B.Sc.:  University College of Wales, U.K.

Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

My research focuses on understanding cell division at the molecular level.  Failure to properly segregate the chromosomes during cell division causes aneuploidy a hallmark of many cancers.  We use  biochemical, genetic and live imaging approaches in frogs, flies and tissue culture systems to address fundamental questions in cell division.

 

Accepting Rotation Students:

YES

 

Mei Zhen

Mei Zhen, Ph.D.

Professor

Address:
Mount Sinai Hospital,
LTRI Rm.870,
600 University Ave.,
Toronto, ON,
M5G 1X5

Phone #: 416-586-1592

Websitehttp://www.mshri.on.ca/zhen/


Research:

Molecular and systems neuroscience in C. elegans
 

Education:

Postdoctoral Fellow:  University of California, Santa Cruz
Ph.D.:  University of British Columbia
B.Sc.:  Wuhan University, China
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease
     

Research Interests:

Our research interest is molecular and systems neuroscience. We address: 1) How the C. elegans’ motor system generates locomotion. We address this question through genetics, optogenetics, electrophysiology, and computational modeling approaches. 2) We use the C. elegans nervous system to address the underlying cellular mechanisms of human disorder in neural development.

 

Accepting Rotation Students:

Yes