Viewing entries tagged
RF-2

Aled Edwards

Aled Edwards, Ph.D.

Professor

Address:
Structural Genome Consortium
MaRS South Tower Rm. 701 
101 College St.
Toronto, ON, M5G 1L5

Phone #:416-946-3795

Web Site: http://www.thesgc.org/about/director


Research:

Developing open access research tools (chemical inhibitors, protein structures and recombinant antibodies)
Additional Affiliations
Structural Genomics Consortium

*currently on leave from Dept. of Molecular Genetics while serving as Director of SGC


Education:

Postdoctoral Fellow: Stanford University
Ph.D.: McGill University
B.Sc.: McGill University


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Medicine and Human Genetics

Research Interests:

Developing open access research tools (chemical inhibitors, protein structures and recombinant antibodies) to increase knowledge of human biology and accelerate drug discovery

 

Sean Egan

Egan.jpg

Sean Egan, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9704
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-5267

Admin: iris.biberstein@sickkids.ca

Web Site: http://www.sickkids.ca/.../Sean-Egan.html


Research:

Mouse models of breast cancer and development


Education:

Postdoctoral Fellow:  The Whitehead Institute/Massachusetts Institute of Technology
Ph.D.:  University of Manitoba, Department of Microbiology
B.Sc. (Hon): University of Manitoba


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

Research Interests:

The Egan lab uses mouse models to study breast cancer and mouse development. For example, we use gene targeting to design models for breast cancer which can be probed to define cooperative signaling networks that are involved in transformation and metastasis, and that can be targeted in the clinic.

 

James Ellis

James Ellis, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9715
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7295

Admin: stella.umana@sickkids.ca

Web Site: http://lab.research.sickkids.ca/ellis/


Research:

Induced pluripotent stem (iPS) cells


Education:

Postdoctoral Fellow:  National Institute for Medical Research, U.K.
Ph.D.: University of Toronto
B.Sc. (Hon): McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

We reprogram patient skin cells into induced pluripotent stem (iPS) cells to study Autism, Cystic Fibrosis and Congenital Heart Disease. The affected cell types are derived from iPS cells for drug discovery. We also study stem cell chromatin structure and generate retrovirus vectors to deliver reporter genes into stem cells.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Alex Ensminger

Alex Ensminger, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1637
Toronto, ON, M5G 1M1

Phone #: 416-978-6522

Web Site: http://individual.utoronto.ca/ensminger_lab/


Research:

Host-pathogen interactions and clinical microevolution of Legionella pneumophila


Education:

Postdoctoral Fellow: Tufts University School of Medicine
Ph.D.: Massachusetts Institute of Technology
B.Sc.: Haverford College


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

We use cutting-edge genomics, experimental evolution, and high-throughput robotics to study host-pathogen interactions and clinical microevolution. Our work is primarily focused on the causative agent of Legionnaires’ Disease, Legionella pneumophila, an often-fatal intracellular bacterial pathogen with a remarkably broad host range.

 

Accepting Rotation Students:

No

 

Oliver Ernst

Oliver Ernst, Dr. rer. nat

Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 5259
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-3849


Research:

G Protein-coupled receptors (GPCRs) mechanism, specificity and structure


Education:

Postdoctoral Fellow/Habilitation: Charité - Universitätsmedizin Berlin, Germany
Ph.D./Dr. rer. nat.: Albert-Ludwigs-Universität, Freiburg, Germany


Fields of Interest:

  • Cellular and Molecular Structure and Function

Research Interests

 Cell membranes are natural borders for signal transduction between cells and their environment. Different strategies to enable signals to cross the membrane barrier employ protein classes such as G protein-coupled receptors (GPCRs), ion channels, and transporters. Our research is directed at understanding transmembrane signaling by GPCRs. We investigate the inner workings of these proteins and their interaction with signaling proteins like G proteins and arrestins. Using different spectroscopic techniques and X-ray crystallography, we aim to get insight into the mechanism, specificity and structural basis of these interactions. A focus of our work is on rhodopsin, the photoreceptor protein in the vertebrate retina. The knowledge how GPCRs work on a molecular level will help to understand their role in health and disease.

 

Lori Frappier

Lori Frappier, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1633
Toronto, ON, M5G 1M1

Phone #: 416-946-3501

Web Site: http://individual.utoronto.ca/frappierlab/index.html


Research:

How herpesvirus promote viral persistence and oncogenesis


Education:

Postdoctoral Fellow: Cornell University Medical College
Ph.D.: McGill University
B.Sc.: Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

We study how herpesvirus  proteins (particularly Epstein-Barr virus) manipulate nuclear processes to promote viral persistence and contribute to oncogenesis, often using proteomics methods.  We also study how PML nuclear bodies are regulated and disrupted by viral proteins, and the functions of a novel DNA replication protein that we discovered by proteomics.

 

Accepting Rotation Students:

Yes

 

Andrew Fraser

Andrew Fraser, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre
Rm. 1212, 160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-2712

Web Site: http://www.fraserlab.org/


Research:

How variations in genome sequence affect phenotype in C. elegans


Education:

Postdoctoral Fellow: Wellcome/CRC Institute, U.K.
Postdoctoral Fellow: Cold Spring Harbor
Ph.D.:  University of London, U.K.
B.Sc. - University of Cambridge, U.K.


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We want to understand how variations in genome sequence affect phenotype in health and disease. To do this, we use the nematode worm as a simple model system in which we can perturb the function of any gene in any genetic background and learn how to predict the outcome.

 

Accepting Rotation Students:

No

 

Barbara Funnell

Barbara Funnell, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1632
Toronto, ON, M5G 1M1

Phone #: 416-978-1665

Web Site: http://individual.utoronto.ca/funnell_lab/


Research:

Chromosome dynamics, segregation of bacterial plasmids


Education:

Postdoctoral Fellow:  Stanford University
Ph.D.:  University of Wisconsin, Madison
B.Sc.:  McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our interest is chromosome dynamics, in particular, the segregation, or partition, of bacterial plasmids. Plasmids carry genes beneficial to their bacterial hosts but often harmful to us, such as antibiotic resistance and pathogenesis genes. We study the mechanism of partition using the P1 plasmid model system in Escherichia coli.

 

Accepting Rotation Students:

No

 

Brenda Gallie

Brenda Gallie, M.D.

Professor

Address:
Princess Margaret Cancer Centre, Rm. 8-415
610 University Ave.
Toronto, ON, M5G 1L7

Phone #: 416-294-9729

Web Site: http://technainstitute.com/p/gallie/profile/


Research:

Diagnosis, prediction and prevention of heritable cancer


Education:

Postdoctoral Fellow:  University of Toronto
M.D.:  Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

Research Interests

My focus is diagnosis, prediction and prevention of heritable cancer. My research uses molecular genomics to understand the cascade of genomic changes that can be targetted to achieve cost-effective health care, including global clinical trials and guidelines, implemented for all 8000 children per year.

 

Anne-Claude Gingras

Anne-Claude Gingras, Ph.D.

Professor

Address:
Mount Sinai Hospital
LTRI, Rm. 992
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-5027

Web Site: http://gingraslab.lunenfeld.ca/


Research:

Proteomics, biochemistry cell biology phosphoregulation


Education:

Postdoctoral Fellow:  Institute for Systems Biology, Seattle
Ph.D.:  McGill University
B.Sc.:  Université Laval, Ste-Foy


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases whose misregulation may result in numerous diseases, including cancer, diabetes and vascular diseases. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to uncover the basis of phosphoregulation.

 

Accepting Rotation Students:

No

 

Scott Gray-Owen

Gray-Owen.jpg

Scott Gray-Owen, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Room 4381
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-946-5307


Research:

Pathogen interactions of human-restricted bacterial and viral pathogens


Education:

Postdoctoral Fellow:  Max Planck Insitut für Biologie, Germany
Ph.D.: University of Calgary  
B.Sc.: University of Calgary


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our research aims to understand how human-restricted bacterial pathogens colonize host tissues and evade the host’s otherwise effective immune response. Our paradigm is the pathogenic Neisseria sp., which includes the bacteria that cause the sexually transmitted disease gonorrhea and rapidly progressing invasive meningococcal meningitis. These bacteria are highly adapted to life in humans, undergoing constant evolution of surface antigens via a combination of antigenic and phase variation, and actively suppressing both innate and adaptive immune responses. Our studies in this regard have led to the development of more relevant in vitro and in vivo models of neisserial infection and disease; to a detailed description of molecular processes that occur downstream of immune activating and inhibitory carcinoembryonic antigen-related cellular adhesion molecule (CEACAM)-related proteins; to reveal a previously unrecognized ‘pathogen-associated molecular pattern’ (PAMP) that allows innate immune detection of bacterial in the tissues; to provide new molecular and immunological insights into the epidemiological synergy between sexually transmitted gonorrhea and HIV-1; to the development of novel vaccines with the potential to broadly protect against neisserial infection; and to the development of a new class of antibiotics that function by activating cylindrical proteases within the bacterial cytoplasm. 

 Publications (Pubmed)   

 

Accepting Rotation Students:

No

 

Jack Greenblatt

Jack Greenblatt, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 960
160 College Street
Toronto, ON M5S 3E1

Phone #: 416-978-4141

Web Site: http://sites.utoronto.ca/greenblattlab/


Research:

Protein-protein and protein-RNA interaction networks for chromatin-related proteins and DNA-binding transcription factors


Education:

Postdoctoral Fellow:  Pasteur Institute, Paris
Ph.D.: Harvard University
B.Sc. (Hon): McGill University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Computational and Systems Biology

 

Research Interests:

Our current major aims are using affinity purification/mass spectrometry and second-generation sequencing to establish protein-protein and protein-RNA interaction networks for the approximately 900 human chromatin-related proteins and  >1000 human DNA-binding transcription factors, as well as to identify some of their important functions in transcription and their relationships to human diseases.

 

Accepting Rotation Students:

Yes

 

Jessica Hill

Jessica Hill, Ph.D.

Assistant Professor

Address:
Room 7253, Medical Sciences Building
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-4707


Education:

Research Fellow: Hospital for Sick Children
Ph.D.: University of Toronto
M.Sc.: University of British Columbia

Research and Teaching:

I am the course coordinator and a lecturer for the online course MGY250, Introduction to Medical Genetics. I am also involved with the online course MGY277, Introduction to Medical Microbiology. 

My research is focused on improving online education in medical genetics and microbiology. In particular, I am interested in evaluating the effectiveness of online educational tools, improving student engagement in online courses and adapting modules for teaching medical genetics and microbiology in various settings.

 

Accepting Rotation Students:

N/A

Sevan Hopyan

Sevan Hopyan, M.D.-Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9713
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301266

Admin: stella.umana@sickkids.ca

Web Site: https://lab.research.sickkids.ca/hopyan/

 


Research:

Morphogenetic mechanisms that shape the limb bud


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Clinical Fellow:  Royal Children's Hospital, Australia
M.D., Ph.D.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

My lab studies morphogenetic mechanisms that shape the initial limb bud and what early molecular events specify skeletal pattern. Our goals are to quantitatively model limb bud growth in 4D, and use what we learn to bioengineer a limb bud in a dish. We also identify mutations that cause human anomalies.

 

Accepting Rotation Students:

No

 

Xi Huang

Xi Huang, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 16-9704
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 309526

Admin: anna.corpuz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/huang/

 

 


Research:

Ion channel functions in brain development and tumorigenesis


Education:

Postdoctoral Fellow:  University of California, San Francisco/Howard Hughes Medical Institute
Ph.D.: Vanderbilt University
B.Sc.: Xiamen University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Cellular & Molecular Structure & Function

 

Research Interests:

Ion channels are pore-forming proteins that control ion flow across cell membranes. Using multidisciplinary approaches including Drosophila and mouse genetics, xenograft modeling, cell biology and electrophysiology, we study the mechanisms by which ion channels regulate brain development and tumorigenesis, and the therapeutic efficacy of ion channel drugs to treat brain tumor.

 

Accepting Rotation Students:

Yes

 

Timothy Hughes

Hughes.jpg

Timothy Hughes, Ph.D.


Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1302
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-946-8260

Web Site: http://hugheslab.med.utoronto.ca/


Research:

How eukarotic cells recognize and interpret the information in the genome, by studying protein-DNA and protein-RNA sequence specificity


Education:

Postdoctoral Fellow:  Rosetta Inpharmatics (now Merck)
Ph.D.:  Baylor College of Medicine
B.Sc., B. Music:  University of Iowa


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

The genome sequence has been described as a blueprint, but it is one that we are largely unable to read.  Our goal is to understand how eukaryotic cells recognize and interpret the information in the genome, by collecting large-scale data on protein-DNA and protein-RNA sequence specificity.

 

Accepting Rotation Students:

Yes

 

Chi Chung Hui

Chi Chung Hui, D.Sc.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 16-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-4994

Admin: katheline.aguilar@sickkids.ca

Web site: http://lab.research.sickkids.ca/hui/

 


Research:

Genetic control of animal development and tumorigenesis


Education:

Postdoctoral Fellow:  National Institute for Basic Biology, Japan
Postdoctoral Fellow: Samuel Lunenfeld Research Institute, Toronto
D.Sc. (Ph.D.): Nagoya University, Japan
M. Phil.: University of Hong Kong
B.Sc. (Hon):   University of Hong Kong


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

We are interested in understanding the genetic control of animal development and the molecular mechanisms involved in tumorigenesis.  We utilize molecular genetic approaches in mice to examine how Gli transcription factors are regulated by Hedgehog-dependent and -independent mechanisms, and the function of Iroquois transcription factors in heart and limb development.

 

Accepting Rotation Students:

Yes

 

Thomas Hurd

Thomas Hurd, Ph.D.

Assistant Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1534
Toronto, ON, M5G 1M1

Phone #: 416-946-3245

Web Site: hurdlab.com


Education:

Postdoctoral Fellow: NYU School of Medicine
Ph.D.: University of Cambridge
B.Sc.: University of Toronto

 

Fields of Interest:

  • Genetic Models of Development and Disease

  • Cellular and Molecular Structure and Function

 

Research Interests:

The Hurd lab is focused on determining how mitochondrial DNA is inherited from mother to offspring, and how mitochondria influence stem cell fate and differentiation. We use an integrative approach that includes molecular genetics, cell biology and state-of-the art microscopy in the model organism Drosophila melanogaster and in mammalian cells.

 

Accepting Rotation Students:

Yes

 

Sadhna Joshi

Joshi.jpg

Sadhna Joshi, D.Sc.

Associate Professor

Address:
Room 4377, Medical Sciences Building
1 King’s College Circle
Toronto, ON M5S 1A8

Phone #: 416-978-2499

Web Site: http://drsadhnajoshi.weebly.com/


Research:

Genetic strategies for HIV-1 prevention


Education:

Postdoctoral Fellow: University of Leiden, The Netherlands
D.Sc., Ph.D.: University of Paris VII, Paris, France
B.Sc.: University Paris VII, Paris, France


Fields of Interest:

Molecular Microbiology and Infectious Disease

 

Research Interests:

Research in my laboratory is focused on the development of genetic strategies for HIV-1 prevention (microflora defense) and treatment (gene therapy). Genes encoding secreted bi- and tri-functional antiviral proteins that inhibit HIV-1 infection of unmodified target cells are used for this purpose.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

Monica Justice

Justice.jpg

Monica Justice, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Room 14-9716
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 x309199

Admin: catherine.tan@sickkids.ca

Web Site: http://lab.research.sickkids.ca/justice/


Research:

Mouse Modeling / Clinical Genetics
Additional Affiliations
Head and Senior Scientist, Program in Genetics and Genome Biology, SickKids


Education:

Postdoctoral Fellow: National Cancer Institute - Frederick Cancer Research and Development Center
Ph.D.: Kansas State University
B.Sc.: Fort Hayes State University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

Dr Justice’s research aims to merge mouse modeling with clinical genetics to understand the basis for human diseases, and to exploit models to improve disease symptoms. Two major projects are 1) eliminating tumour-initiating cells in childhood cancers and 2) discovering pathways for therapeutic intervention in Rett Syndrome through genetic suppressors.

 

Accepting Rotation Students:

Yes