Viewing entries tagged
RF-3

Jun Liu

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Jun Liu, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1615
Toronto, ON, M5G 1M1

Phone #: 416-946-5067

Web Site: http://sites.utoronto.ca/liulab/


Research:

Novel strategies for the control of tuberculosis, and design of effective TB vaccines


Education:

Postdoctoral Fellow:  University of California, Berkeley
Ph.D.:  Medical College of Wisconsin
B.Sc.:  Peking University, China


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

Research Interests:

Our research goal is to develop novel strategies for the control of tuberculosis, one of the world’s most deadly infectious diseases.  We are working on understanding how Mycobacterium tuberculosis maintains persistent infection in the host and how to rationally design the next generation of effective TB vaccines.

 

Currently Accepting Graduate Students

Philipp Maass

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Philipp Maass, Ph.D

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 14-9715
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 x302181

Admin: Meghan.Bradley@sickkids.ca

Web site: https://lab.research.sickkids.ca/maass/


Education:

Postdoctoral Fellow:  Harvard University
Postdoctoral Fellow: Max Delbrück Center for Molecular Medicine
Ph.D.: Humboldt University Berlin, Max Delbrück Center for Molecular Medicine
Diploma in Biology, Eberhard Karls University Tübingen, Germany


Fields of Interest:

  • Molecular Medicine & Human Genetics

  • Genetic Models of Development and Disease

 

Research Interests:

Inter-chromosomal interactions between different chromosomes drive gene regulation, but their molecular mechanisms remain elusive. To better understand biology and etiology of disease, the Maass lab focuses on inter-chromosomal interactions, especially of the noncoding genome, that impact development and disease mechanisms in a bedside-to-bench approach.

 

Accepting Rotation Students:

Yes

Marc Meneghini

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Marc Meneghini, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1532
Toronto, ON, M5G 1M1

Phone #: 416-978-7578

Web Site: http://sites.utoronto.ca/molgen/Site/home.html


Research:

Saccharomyces cerevisiae epigenetic control of gene expression during sporulation and novel form of programed death


Education:

Postdoctoral Fellow:  University of California, San Francisco
Ph.D.:  University of Oregon
B.S.:  St. Michael's College


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

The lab’s interests concern mechanisms of eukaryotic cellular differentiation. As a model, we use the sporulation program of the budding yeast Saccharomyces cerevisiae. We study epigenetic mechanisms controlling gene expression during sporulation as well as a new and novel form of programmed death we have recently discovered accompanies this process.

 

Accepting Rotation Students:

Yes

 

Freda Miller

Freda Miller, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 18-9716
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301434

Admin: michelle.driz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/miller-kaplan/

 


Research:

Cellular mechanisms that regulate development of the mammalian nervous system


Education:

Postdoctoral Fellow:  Scripps Research Institute
Ph.D.:  University of Calgary
B.Sc.:  University of Saskatchewan


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

My laboratory is interested in the cellular mechanisms that regulate development of the mammalian nervous system, with a particular interest in stem cells and trophic factors.

 

Accepting Rotation Students:

No

 

Jason Moffat

Jason Moffat, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 802
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-0336

Web Site: http://moffatlab.ccbr.utoronto.ca/


Research:

Genetic interaction networks in cancer cells.


Education:

Postdoctal Fellow:  Massachusetts Institute of Technology
Ph.D.:  University of Toronto
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Functional Genomics and Proteomics

 

Research Interests:

The Moffat lab is interested in cancer and genetic interaction networks in cancer cells.

 

Accepting Rotation Students:

Yes

 

Michael Moran

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Michael Moran, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 17-9705
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 647-235-6435

Admin: katie.jackson@sickkids.ca

Web Site: http://www.sickkids.ca/.../Moran%20.html


Research:

Proteomics and functional genomics to define and stratify cancers focused on signal transduction and metabolic networks


Education:

Postdoctoral Fellow:  Mt. Sinai Hospital, Toronto
Ph.D.:  University of Western Ontario
B.Sc.:  University of Western Ontario


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Functional Genomics and Proteomics

 

Research Interests:

Proteomics and functional genomics datasets are integrated in order to define and stratify cancers according to their distinctive molecular signatures. Underlying signal transduction and metabolic networks, and their regulation by post-translational modifications, are then molecularly characterized for their contributions to cancer phenotypes.

 

Accepting Rotation Students:

Yes

 

Quaid Morris

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Quaid Morris, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 616
160 College St.
Toronto, Ontario, M5S 3E1

Phone #: 416-978-8568

Web Site: http://www.morrislab.ca/


Research:

Computational biology, machine learning, gene function prediction, post-transcriptional regulation


Education:

Postdoctoral Fellow:  University of Toronto
Postdoctoral Fellow:  OCI, University Health Network
Ph.D.:  Massachusetts Institute of Technology
B.Sc. (Hon): University of Toronto


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

Proteomics and functional genomics datasets are integrated in order to define and stratify cancers according to their distinctive molecular signatures. Underlying signal transduction and metabolic networks, and their regulation by post-translational modifications, are then molecularly characterized for their contributions to cancer phenotypes.

 

Accepting Rotation Students:

Yes

 

Julien Muffat

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Julien Muffat, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 17-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 309997

Admin: julie.meltzer@sickkids.ca

Web Site: http://www.sickkids.ca/AboutSickKids/Directory/People/M/julien-muffat.html


Education:

Postdoctoral Fellow: Whitehead Institute for Biomedical Research, MIT
Ph.D.: California Institute of Technology
M.Sc., B.Sc: Université de Paris

Fields of Interest:

  • Genetic Models of Development & Disease

  • Cellular & Molecular Structure & Function

 

Research Interests:

I develop novel 3D cultures derived from human iPSCs to study degenerative diseases of the brain. I focus on neuro-immune aetiologies of diseases ranging from autism to Alzheimer's, highlighting the role of microglia in establishing neuronal dysfunction. CRISPR/Cas9 genome engineering allows functional interrogation of disease-associated variants expressed exclusively in microglia.

 

Accepting Rotation Students:

Yes

William Navarre

William Navarre, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1635
Toronto, ON, M5G 1M1

Phone #: 416-946-5356

Web Site: http://navarrelab.ca


Research:

Molecular mechanisms controlling the expression of genes required for bacterial virulence


Education:

Postdoctoral Fellow: University of Washington School of Medicine
Postdoctoral Fellow:  New York University School of Medicine
Ph.D.:  University of California, Los Angeles
B.S.: University of Michigan


Fields of Interest:

  • Functional Genomics and Proteomics

  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Research in the Navarre lab is aimed at understanding the molecular mechanisms controlling  the expression of genes required for bacterial virulence.  The lab has a central focus on the genomic evolution and lateral gene transfer, which plays a primary role in the evolution of pathogens and the rapid spread of antibiotic resistance. The lab also has a growing interest in understanding the microbiota of laboratory animals.

 

Accepting Rotation Students:

Yes

 

Kenichi Okamoto

Kenichi Okamoto, Ph.D.

Assistant Professor

Address:
Mount Sinai Hospital
LTRI Rm.884
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 ext.4936

Web Site: http://www.lunenfeld.ca/researchers/okamoto


Research:

Developing novel technologies to visualize and manipulate protein function in the brain


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  Osaka University, Japan
M.A.:  Toyama University, Japan
B.S.:  Toyama University, Japan


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Elucidating the mechanisms of learning and memory is essential for understanding brain diseases such as Alzheimer’s disease and Autism. We aim to dissect the complex signaling cascades for learning & memory and related brain diseases by developing novel technologies to visualize and manipulate protein function in the brain.

 

Accepting Rotation Students:

Yes

 

Lucy Osborne

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Lucy Osborne, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1515
Toronto, ON, M5G 1M1

Phone #: 416-946-5804

Web Site: http://individual.utoronto.ca/osbornelab/


Research:

Mouse models and the genetic analysis of human subjects to probe the molecular basis of neurodevelopmental disorders


Education:

Postdoctoral Fellow:  Hospital for Sick Children, Toronto
Ph.D.:  National Heart & Lung Institute, U.K.
M.Sc.: University College London, U.K.
B.Sc. (Hon): City of London Polytechnic, U.K. 


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Both deletion and duplication of human chromosome 7q11.23 cause neurodevelopmental disorders with unique phenotypic profiles, so offering a window into the genetics of human behavior, cognition and language. We use mouse models and the genetic analysis of human subjects to probe the underlying molecular basis of these disorders.

 

Accepting Rotation Students:

No

 

 

Jeehye Park

Jeehye Park, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning,            Rm 14.9702
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7670

Admin: irina.iovu@sickkids.ca

Web Site: http://www.sickkids.ca/Research/Genetics-and-genome-biology/who-we-are/index.html


Research:

Molecular mechanisms underlying neurodegenerative diseases


Education:

Postdoctoral fellow: Baylor College of Medicine & Howard Hughes Medical Institute  
Ph.D.: Korea Advanced Institute of Science and Technology  
B.S.: Korea Advanced Institute of Science and Technology


Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics

 

Research Interests:

Our laboratory is interested in understanding the molecular mechanisms underlying neurodegenerative diseases with the aim of identifying targetable pathways for therapeutic interventions. Our studies utilize multidisciplinary approaches including biochemistry, molecular cell biology, and Drosophila and mouse genetics.

 

Accepting Rotation Students:

Yes

 

John Parkinson

John Parkinson, Ph.D.

Professor

Address:
Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Rm. 21.9709
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-5746

Web Site: http://www.compsysbio.org/


Research:

Evolution and operation of biological systems that pertain to human disease


Education:

Postdoctoral Fellow:   University of Manitoba
Postdoctoral Fellow:   University of Edinburgh, U.K.
Ph.D.:  University of Manchester, U.K.
B.Sc. (Hon): University of Bath, U.K.


Fields of Interest:

  • Computational and Systems Biology
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Our labs interests are focused on the evolution and operation of biological systems, particularly those that pertain to human disease. Specific systems of interests include those that allow bacterial pathogens and parasites to survive and persist within their human hosts. In collaboration with the NIH, we are actively developing and applying novel integrative strategies that combine mathematical models with functional genomics to target parasite metabolism.

 

Accepting Rotation Students:

Yes

 

Bret Pearson

Bret Pearson, Ph.D.

Associate Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for Research &
Learning, Rm. 18-9713, 686 Bay St.,
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 328370

Admin: meera.kamal@sickkids.ca

Web Site: 

http://lab.research.sickkids.ca/pearson/

 

 


Research:

Planarian as an in vivo model system to study stem cells and regeneration

Education:

Postdoctoral Fellow:  University of Utah    
Ph.D.:  University of Oregon
B.S.:  University of Wisconsin, Madison
 

Fields of Interest:

  • Genetic Models of Development and Disease
  • Molecular Medicine and Human Genetics


Research Interests:

We focus on how adult stem cells make a correct cell lineage in space and time to replace the exact number of cells lost to tissue turnover or injury. To this end, my lab uses the freshwater planarian as an in vivo model system to study stem cells and regeneration.

 

Accepting Rotation Students:

Yes

 

Christopher Pearson

Christopher Pearson, Ph.D.

Professor

Address:
Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Rm. 14-9714, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8256

Admin: Irina.Iovu@sickkids.ca

Web Site: http://www.cepearsonlab.com/


Research:

DNA repeat instability


Education:

Postdoctoral Fellow:  Texas Medical Center
Ph.D.:  McGill University
B.Sc. (Hon):  Concordia University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

Understand DNA repeat instability; the cause of >40 diseases including Huntington's disease, muscular dystrophy & amyotrophic lateral sclerosis.
Use molecular, stem cell, transgenic mouse models and human tissues to understand and modulate this mutation for clinical benefit.
Focus on DNA repair, replication & epigenetics.
Identify therapeutic targets and preclinical therapeutic drugs.

 

Accepting Rotation Students:

Yes

 

Laurence Pelletier

Laurence Pelletier, Ph.D.

Professor

Address:
Mt. Sinai Hospital, LTRI, Room 1070
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 x6196

Web Site: http://pelletierlab.org


Research:

Centrosome biogenesis and function


Education:

Ph.D.:  Yale University
M.Sc.:  University of Montreal
B.Sc.:  University of Montreal


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

Our laboratory studies several facets of centrosome biogenesis and function, with a particular emphasis on how their perturbation can lead to genome instability, developmental diseases and cancer. Using functional genomic approaches and cutting-edge microscopy and biochemistry, our overarching goal is to identify and study novel proteins required centrosome and to investigate their potential role in development and diseases.

 

Accepting Rotation Students:

Yes

 

Stephanie Protze

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Stephanie Protze, Ph.D.

Assistant Professor

Address:
McEwen Institute, University Health Network
PMCRT 3-918
101 College St.
Toronto, ON, M5G 1L7

Phone #: 416-634-8179

Web Site: https://www.uhnresearch.ca/researcher/stephanie-protze


Education:

Postdoctoral Fellowship:  McEwen Centre, University Health Network, Toronto
PhD: Dresden University of Technology, Germany
B.Sc: Dresden University of Technology, Germany


Fields of Interest:

  • Genetic Models of Development and Disease
  • Cellular and Molecular Structure and Function

 

Research Interests:

We are studying human heart development and disease using the human pluripotent stem cell model system. To facilitate that, my lab has specialized in developmental biology-based differentiation strategies. Our current research focuses on cardiac pacemaker cells and their application for in vitro disease modeling and cell therapies as biological pacemaker.

 

Accepting Rotation Students:

Yes

Miguel Ramalho-Santos

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Miguel Ramalho-Santos, Ph.D.

Professor

Address:
Lunenfeld-Tannenbaum Research Institute
Room 6-1016-2
25 Orde St.
Toronto, ON, M5T 3H7

Phone #: 416-586-4800 x8377

Web Site: https://www.mrsantoslab.org


Education/Professional:

Faculty member:  University of California, San Francisco
Ph.D. & Postdoc:  Harvard University
M.Sc.: University of Coimbra, Portugal


Fields of Interest:

  • Genetic Models of Development & Disease

  • Cellular & Molecular Structure & Function

 

Research Interests:

Our lab is interested in understanding the epigenetic regulation of mammalian development and reproduction. Work from our lab highlights that such foundational aspects as genome organization, transcription and environmental input are regulated in unique ways in pluripotent stem cells of the early embryo and the germline.

 

Accepting Rotation Students:

Yes

Aaron Reinke

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Aaron Reinke, Ph.D.

Assistant Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1621A
Toronto, ON, M5G 1M1

Phone #: 416-946-0889

Web Site: https://www.reinkelab.org/


Education:

Postdoctoral Fellow:  University of California, San Diego
Ph.D.: Massachusetts Institute of Technology
B.Sc: University of California, Davis

Fields of Interest:

  • Molecular Microbiology & Infectious Disease
  • Functional Genomics and Proteomics

 

Research Interests:

Research in the Reinke lab focuses on exploring the evolution of host-pathogen interactions, primarily studying microsporidia, which are fungal related intracellular pathogens with the smallest known eukaryotic genomes. We investigate these fascinating pathogens using the tractable animal host C. elegans, using an integrative approach of genetic, bioinformatic and biochemical techniques.

 

Accepting Rotation Students:

Yes

 

James Rini

James Rini, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1614
Toronto, ON, M5G 1M1

Phone #: 416-978-0557
 


Research:

Using X-ray crystallography and biochemistry to study protein folding and coronavirus-host cell receptor interactions


Education

Postdoctoral Fellow:  Research Institute of Scripps Clinic, California
Ph.D.:  University of Toronto
B.Sc.:  University of Toronto


Fields of Interest

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests

Our research is focused on the study of: i) ER-resident glycosyltransferases and their role in protein folding and quality control, and ii) coronavirus-host cell receptor interactions. In all cases we seek to determine structure-function relationships using x-ray crystallography and complementary biochemical and cell-based approaches.

 

Accepting Rotation Students:

No