Viewing entries tagged
RF-4

Sachdev Sidhu

Sachdev Sidhu, Ph.D.

Professor

Address:
University of Toronto,
The Donnelly Centre, Rm. 816
160 College St., Toronto, ON, M5S 3E1

Phone #: 416-946-0863

Web Sitehttp://sites.utoronto.ca/sidhulab/


Research:

Protein engineering to design synthetic antibodies to target and modulate protein-protein interactions

Education:

Postdoctoral Fellow:  Genentech Inc., California
Ph.D.:  Simon Fraser University
B.Sc. (Hon):  Simon Fraser University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics
     

Research Interests:

My group uses protein engineering to design synthetic antibodies and other proteins to target and modulate the natural protein-protein interactions. We use these synthetic agents to investigate the roles of key protein-protein interactions in normal and diseased cellular states with the aim of developing novel therapuetics.

 

Accepting Rotation Students:

Yes

 

Craig Smibert

Craig Smibert, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1537
Toronto, ON, M5G 1M1

Phone #: 416-946-5538

Web Sitehttp://biochemistry.utoronto.ca/person/craig-a-smibert/

 


Research:

Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation

Education:

Postdoctoral Fellow: Stanford University
Ph.D.:  McMaster University
B.Sc.:  McMaster University
 

Fields of Interest:

  • Functional Genomics and Proteomics
  • Genetic Models of Development and Disease
     

Research Interests:

Post-transcriptional regulation of gene expression is achieved through the control of mRNA translation, mRNA stability and subcellular mRNA localization. Post-transcriptional regulation is mediated by RNA-binding proteins and regulatory RNAs that recognize specific sequences within target transcripts. We use both Drosophila and yeast to study the mechanisms that underlie post-transcriptional regulation.

 

Accepting Rotation Students:

Yes

 

Neal Sondheimer

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Neal Sondheimer, M.D.,Ph.D.

Associate Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 12-9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301480

Admin: denese.henry@sickkids.ca

Web Site: https://tinyurl.com/y9jzjmq6

 


Research:

My Research focuses on the regulation of mitochondrial gene expression and the impact of
mitochondrial mutations in common and rare disease.


Education:

Postdoctoral Fellow:  University of Pennsylvania (Genetics)
M.D., Ph.D.:  University of Chicago
B.A.: Harvard College (Biology)


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

Research Interests:

Mitochondrial DNA variants act as either a low penetrance risk factor for common disorders or as a high penetrance cause of frank mitochondrial failure. In the lab, we study how mitochondrial variants interact with each other and with the nuclear genome to impact organellar function.

 

Accepting Rotation Students:

Yes

 

Andrew Spence

Andrew Spence, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1501
Toronto, ON, M5G 1M1

Phone #: 416-978-6406

Web Sitehttp://www.spencelab.ca


Research:

Determination of sex-specific cell fates in Caenorhabditis elegans via a novel form of epigenetic regulation
 

Education:

Postdoctoral Fellow:  MRC Laboratory of Molecular Biology, U.K.
Ph.D.:  University of British Columbia
B.Sc.:  University of Winnipeg
 

Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

Research Interests:

We study genes that determine sex-specific cell fates in Caenorhabditis elegans. We have described a novel form of epigenetic regulation that depends upon maternally contributed RNA to license gene expression in the germ line of the next generation, and we are using genetic and genomic approaches to understand its mechanism.

 

Accepting Rotation Students:

No

 

Igor Stagljar

Igor Stagljar, Ph.D.

Professor

Address:
University of Toronto,
Donnelly Centre, Rm. 1204
160 College St., Toronto, ON M5S 3E1

Phone #: 416-946-7828

Web Sitehttp://biochemistry.utoronto.ca/stagljar/


Research:

Studies of yeast and human integral membrane proteins in cell signaling and membrane transport at a system level

Education:

Postdoctoral Fellow:  University of Zurich & University of Washington (Seattle)
Ph.D.:  Swiss Federal Institute of Technology (ETH) Zurich, Switzerland
B.Sc.:  University of Zagreb, Croatia
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics
     

Research Interests:

A focus of my lab is to understand the function of the majority of “druggable” yeast and human integral membrane proteins involved in cell signaling and membrane transport at a systems level. Despite extensive research in the past decade, there is a lack of in-depth understanding of protein networks associated with these integral membrane proteins because of their unique biochemical features, enormous complexity and multiplicity. This is a major obstacle for designing improved and more targeted therapies, and importantly, understanding the biology of deregulation of these integral membrane proteins which leads to numerous human diseases.  To address this challenge, we are applying an in vivo genetic system previously developed in my lab, called the membrane yeast two-hybrid (MYTH) assay, to identify and characterize protein interactors of all yeast ABC transporters and human receptor tyrosine kinases (RTKs), as well as selected cancer stem cell receptors (CSCRs) and G-protein coupled receptors (GPCRs).  In   the past years, we have shown that the newly identified interactors of these various integral membrane proteins play novel roles in regulating their activity both in vivo and in vitro. In this way, our systematic MYTH approach offers an unbiased systems level view that facilitates the identification of novel drug targets, thereby promising significant contributions to therapeutic research.

 

Lincoln Stein

Lincoln Stein, M,D., Ph.D.

Professor

Address:
OICR, MaRS West Tower,
Suite 510
661 University Ave.,
Toronto, ON, M5G 0A3

Phone #: 416-673-8514


Research:

Network and pathway-based analysis to identify common mechanisms in multiple cancer types and to devise prognostic and predictive signatures
 

Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  Harvard University
M.D.:  Harvard Medical School
B.A.:  Johns Hopkins University
 

Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics


Research Interests:

Stein's research focuses on using network and pathway-based analysis to identify common mechanisms in multiple cancer types and to devise prognostic and predictive signatures to aid in patient management. In addition, his group works on problems relating to the genome structure and function of the nematode Caenorhabditis elegans.

 

Accepting Rotation Students:

Yes

 

Martina Steiner

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Martina Steiner, Ph.D.

Assistant Professor

Address:
Room 7263, Medical Sciences Building
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-3726

Education:

Ph.D., M.Sc., B.Sc.: ETH Zurich
M.Ed.: Paedagogische Hochschule Thurgau, Switzerland

Research and Teaching:

Martina obtained a Ph.D. in biochemistry from ETH Zurich, Switzerland, researching methods for targeted delivery of cytotoxic agents to sites of cancer.  In addition, Martina holds a Master's degree in Secondary and Higher education and has over eight years of experience teaching students at different levels.

In 2015, Martina moved to California where she worked at the Stanford Online High School, applying novel methods in online and one-on-one teaching. In 2017, she was appointed Assistant Professor, teaching stream at the University of Toronto, where her main focus is to establish and teach in the M.H.Sc. Medical Genomics program.

 

Accepting Rotation Students:

N/A

Boris Steipe

Boris Steipe, M.D., Ph.D.

Associate Professor

Address:
University of Toronto,
Medical Sciences Building, Rm. 5271
1 King's College Circle,
Toronto, ON M5S 1A8

Phone #: 416-946-7741

Web Sitehttp://biochemistry.utoronto.ca/steipe/


Research:

Patterns in molecular structure: computational methods of pattern discovery
 

Education:

Postdoctoral Fellow: Max-Planck-Institute for Biochemistry, Germany
Ph.D., M.D.:  University of Munich, Germany
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Computational and Systems Biology
     

Research Interests:

I am interested in recurring patterns in molecular structure: the computational methods of pattern discovery, their characterization regarding features, context and distribution,  their association with function in proteins, and their utility for protein engineering and design.

 

Accepting Rotation Students:

No

 

Erin Styles

EbStyles.png

Erin Styles, Ph.D.

Assistant Professor

Address:
Room 7267, Medical Sciences Building
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-4481

Education:

Research Fellow: University of Toronto
Ph.D.: University of Toronto
B.Sc.: University of Guelph and University of Sydney, AU

Research and Teaching:

As the director of the Masters of Heath Sciences program in Medical Genomics, my focus is on designing and implementing a professional masters program that provides practical, actionable training in medical genetics and genomics. My research focuses on course and program assessments of success, including the attainment of learning objectives within individual courses, post-graduate success, and the overall impact of the program on patient health outcomes and the adaptation of genomic medicine at the front lines of care.

 

Accepting Rotation Students:

N/A

 

Mikko Taipale

Mikko Taipale, Ph.D.

assistant PROFESSOR

Address:
University of Toronto
The Donnelly Centre, Rm. 806
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-0812

Web Site:  www.taipalelab.org


RESEARCH:

Protein homeostasis network


EDUCATION:

Postdoctoral Fellow: Whitehead Institute, Cambridge MA
Ph.D.: European Molecular Biology Laboratory, Heidelberg, Germany
M.Sc.: University of Oulu, Finland


FIELDS OF INTEREST:

  • Functional Genomics and Proteomics
  • Cellular & Molecular Structure & Function

RESEARCH INTERESTS:

I am interested in the protein homeostasis network, how it is organized in the cell, how it has diversified during millions of years of evolution, and how it is regulated in health and disease. My laboratory also develops functional proteomics methods for investigating challenging biomolecular interactions, such as drug/target and ligand/receptor interactions.

 

Accepting Rotation Students:

Yes

 

Derek van der Kooy

Derek van der Kooy, Ph.D.

Professor

Address:
University of Toronto, The Donnelly Centre, Rm. 1102
160 College St., Toronto, ON M5S 3E1

Phone #: 416-978-1960

Web Site: http://sites.utoronto.ca/neurobiology/

 


Research:

Stem cell and developmental biology

Education:

Postdoctoral Fellow:  Cambridge University, U.K.
Postdoctoral Fellow:  Salk Institute
Ph.D.:  University of Toronto
M.A.:  University of British Columbia
 

Fields of Interest

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease
     

Research Interests

The van der Kooy lab works on various stem cell biology and developmental biology research projects; specifically, stem cells in organisms from Drosophila to humans. We produced the first report of stem cells in the adult mammalian eye, published in 2000 in Science. We have also isolated a rare stem cell from the adult mouse and human pancreas that can show extensive proliferation under defined conditions in vitro. Of interest to the lab is the lineage of neural stem cells from pluripotent embryonic stem cells, with relevance to the origin of the earliest neural stem cell in the developing embryo.

 

Accepting Rotation Students:

Yes

 

Andrew Wilde

Andrew Wilde, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1516
Toronto, ON, M5G 1M1

Phone #: 416-946-7714

Websitehttp://individual.utoronto.ca/wildelab


Research:

Biochemical, genetic and live imaging approaches in frogs, flies and tissue culture systems to address fundamental questions in cell division

Education:

Postdoctoral Fellow:  Carnegie Institution of Washington
Postdoctoral Fellow:  University of California, San Francisco
Ph.D.:  University of Bristol, U.K.
B.Sc.:  University College of Wales, U.K.

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

My research focuses on understanding cell division at the molecular level.  Failure to properly segregate the chromosomes during cell division causes aneuploidy a hallmark of many cancers.  We use  biochemical, genetic and live imaging approaches in frogs, flies and tissue culture systems to address fundamental questions in cell division.

 

Accepting Rotation Students:

No

 

Michael Wilson

Michael Wilson, Ph.D.

Associate Professor

Address:
Hospital for Sick Children,
Peter Gilgan Centre for Research & Learning,
Rm. 14-9713,
686 Bay St., Toronto,
ON M5G 0A4

Phone #: (416) 813-7654 ext. 328699

Admin: catherine.tan@sickkids.ca

Web Site: http://www.wilsonlab.org/


Research:

Comparative genome biology, epigenetics and evolution of regulatory networks

Education:

Postdoctoral Fellow:  University of Cambridge, U.K.
Postoctoral Fellow: University of Victoria, B.C.
Ph.D.:  University of Victoria
B.Sc.:  University of Victoria
 

Fields of Interest

  • Computational and Systems Biology
  • Functional Genomics and Proteomics
     

Research Interests:

  • Comparative genome biology, Functional genomics,  Bioinformatics,  Developmental biology    
  • Characterizing the role that regulatory DNA sequence plays in childhood diseases using comparative genomics, bioinformatics and developmental biology.
  • Epigenetics and evolution of regulatory networks in postnatal germ cells.
  • Modeling of human genome innovations.

 

Accepting Rotation Students:

Yes

 

Jeff Wrana

Jeff Wrana, Ph.D.

Professor

Address:
Mount Sinai Hospital,
LTRI Rm.1070
600 University Ave.,
Toronto, ON, M5G 1X5

Phone #: 416-586-4800

Web Sitehttp://sites.utoronto.ca/attisano


Research:

Signalling pathways integration into higher order networks that control development cancer initiation and progression

Education:

Postdoctoral Fellow: Memorial Sloan Kettering Cancer Center, NY
Ph.D.:  University of Toronto
B.Sc.:  University of Toronto
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics
     

Research Interests:

We seek to understand how signalling pathways are integrated into higher order networks that control morphogenesis in development and which are aberrantly organized during cancer initiation and progression.

 

Accepting Rotation Students:

Yes

 

Ryan Yuen

Yuen, Ryan_Photo_8Aug2018.jpg

Ryan Yuen, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 13.9712
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301022

Admin: Darvy.Teav@sickkids.ca

 


EDUCATION:

Postdoctoral Fellow: The Hospital for Sick Children
Ph.D.: University of British Columbia
M.Phil.: Chinese University of Hong Kong                                                                                           B.Sc.: Hong Kong University of Science and Technology


FIELDS OF INTEREST:

  • Molecular Medicine & Human Genetics

  • Functional Genomics & Proteomics

 

RESEARCH INTERESTS:

We are interested in understanding how genetic and epigenetic variations contribute to human health, with a focus on neurodevelopmental and neurological disorders. Utilizing (epi)genomic technologies, we aim to develop novel disease gene discovery strategies, effective diagnostic approaches and better treatments for the disorders.

 

Accepting Rotation Students:

Contact PI directly for more information.

 

 

Zhaolei Zhang

Zhaolei Zhang, Ph.D.

Professor

Address:
University of Toronto,
The Donnelly Centre, Rm. 608
160 College St.,
Toronto, ON
M5S 3E1

Phone #: 416-946-0924

Websitehttp://sites.utoronto.ca/zhanglab/


Research:

Comparative genomics, genome evolution, microRNAs, genetic variations
 

Education:

Postdoctoral Fellow:  Yale University
Ph.D.:  University of California,Berkeley
B.Sc.:  NanKai University, China
 

Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics
     

Research Interests:

Comparative genomics, genome evolution, gene duplication, pseudogenes, microRNAs, genetic variations

 

Mei Zhen

Mei Zhen, Ph.D.

Professor

Address:
Mount Sinai Hospital,
LTRI Rm.870,
600 University Ave.,
Toronto, ON,
M5G 1X5

Phone #: 416-586-1592

Websitehttp://www.mshri.on.ca/zhen/


Research:

Molecular and systems neuroscience in C. elegans
 

Education:

Postdoctoral Fellow:  University of California, Santa Cruz
Ph.D.:  University of British Columbia
B.Sc.:  Wuhan University, China
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease
     

Research Interests:

Our research interest is molecular and systems neuroscience. We address: 1) How the C. elegans’ motor system generates locomotion. We address this question through genetics, optogenetics, electrophysiology, and computational modeling approaches. 2) We use the C. elegans nervous system to address the underlying cellular mechanisms of human disorder in neural development.

 

Accepting Rotation Students:

Yes