Viewing entries tagged
SF-2

Julie Lefebvre

Lefebvre.jpg

Julie Lefebvre, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Center for Research and Learning Rm 59707
686 Bay St.
Toronto ON M5G 0A4

Phone #: 416-813-7654 ext 309248

Web Site: http://www.sickkids.ca/.../julie-lefebvre-staff-profile.html


Research:

Neural Circuit Development


Education:

Postdoctoral Fellowship:  Harvard University, Neurobiology
PhD: University of Pennsylvania, Cell & Molecular Biology
BSc: McGill University, Honours Physiology


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

Our laboratory studies how developing neurons precisely organize into neural circuits.  We study molecular and cellular mechanisms that specify neuronal wiring patterns and partners.  Using transgenic mice, genetic and viral approaches to visualize neurons, and cutting-edge microscopy, we study how these pathways govern the assembly and function of neural circuits in the brain and retina.

 

Accepting Rotation Students:

Yes

 

Yun Li

LI, YUN_22FEB2018_DSC9904.jpg

Yun Li, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 17-9709
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 309083

Admin: katie.jackson@sickkids.ca

Web Site: http://www.sickkids.ca/AboutSickKids/Directory/People/L/yun-li-staff-profile.html


Education:

Postdoctoral Fellow: Whitehead Institute for Biomedical Research, MIT
Ph.D.: University of Texas, Southwestern Medical Center
B.Sc: Wuhan University, China

Fields of Interest:

  • Genetic Models of Development & Disease

  • Cellular & Molecular Structure & Function

 

Research Interests:

The Li Lab is interested in understanding how the human brain forms, what makes it unique from that of other species, and how disorders like autism impact its development and function. We use pluripotent stem cell, genome editing, and 3-dimensional organoid technologies to study brain development in a dish.

 

Accepting Rotation Students:

Yes

 

Jun Liu

Liu.jpg

Jun Liu, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1615
Toronto, ON, M5G 1M1

Phone #: 416-946-5067

Web Site: http://sites.utoronto.ca/liulab/


Research:

Novel strategies for the control of tuberculosis, and design of effective TB vaccines


Education:

Postdoctoral Fellow:  University of California, Berkeley
Ph.D.:  Medical College of Wisconsin
B.Sc.:  Peking University, China


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

Research Interests:

Our research goal is to develop novel strategies for the control of tuberculosis, one of the world’s most deadly infectious diseases.  We are working on understanding how Mycobacterium tuberculosis maintains persistent infection in the host and how to rationally design the next generation of effective TB vaccines.

 

Currently Accepting Graduate Students

Marc Meneghini

Meneghini.jpg

Marc Meneghini, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1532
Toronto, ON, M5G 1M1

Phone #: 416-978-7578

Web Site: http://sites.utoronto.ca/molgen/Site/home.html


Research:

Saccharomyces cerevisiae epigenetic control of gene expression during sporulation and novel form of programed death


Education:

Postdoctoral Fellow:  University of California, San Francisco
Ph.D.:  University of Oregon
B.S.:  St. Michael's College


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

The lab’s interests concern mechanisms of eukaryotic cellular differentiation. As a model, we use the sporulation program of the budding yeast Saccharomyces cerevisiae. We study epigenetic mechanisms controlling gene expression during sporulation as well as a new and novel form of programmed death we have recently discovered accompanies this process.

 

Accepting Rotation Students:

Yes

 

Freda Miller

Freda Miller, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 18-9716
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301434

Admin: michelle.driz@sickkids.ca

Web Site: http://lab.research.sickkids.ca/miller-kaplan/

 


Research:

Cellular mechanisms that regulate development of the mammalian nervous system


Education:

Postdoctoral Fellow:  Scripps Research Institute
Ph.D.:  University of Calgary
B.Sc.:  University of Saskatchewan


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

 

Research Interests:

My laboratory is interested in the cellular mechanisms that regulate development of the mammalian nervous system, with a particular interest in stem cells and trophic factors.

 

Accepting Rotation Students:

No

 

Michael Moran

Moran.jpg

Michael Moran, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 17-9705
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 647-235-6435

Admin: katie.jackson@sickkids.ca

Web Site: http://www.sickkids.ca/.../Moran%20.html


Research:

Proteomics and functional genomics to define and stratify cancers focused on signal transduction and metabolic networks


Education:

Postdoctoral Fellow:  Mt. Sinai Hospital, Toronto
Ph.D.:  University of Western Ontario
B.Sc.:  University of Western Ontario


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Functional Genomics and Proteomics

 

Research Interests:

Proteomics and functional genomics datasets are integrated in order to define and stratify cancers according to their distinctive molecular signatures. Underlying signal transduction and metabolic networks, and their regulation by post-translational modifications, are then molecularly characterized for their contributions to cancer phenotypes.

 

Accepting Rotation Students:

Yes

 

Julien Muffat

portrait-muffat.png

Julien Muffat, Ph.D.

Assistant Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 17-9708
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 309997

Admin: katie.jackson@sickkids.ca

Web Site: http://www.sickkids.ca/AboutSickKids/Directory/People/M/julien-muffat.html


Education:

Postdoctoral Fellow: Whitehead Institute for Biomedical Research, MIT
Ph.D.: California Institute of Technology
M.Sc., B.Sc: Université de Paris

Fields of Interest:

  • Genetic Models of Development & Disease
  • Cellular & Molecular Structure & Function

 

Research Interests:

I develop novel 3D cultures derived from human iPSCs to study degenerative diseases of the brain. I focus on neuro-immune aetiologies of diseases ranging from autism to Alzheimer's, highlighting the role of microglia in establishing neuronal dysfunction. CRISPR/Cas9 genome engineering allows functional interrogation of disease-associated variants expressed exclusively in microglia.

 

Accepting Rotation Students:

Yes

Kenichi Okamoto

Kenichi Okamoto, Ph.D.

Assistant Professor

Address:
Mount Sinai Hospital
LTRI Rm.884
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 ext.4936

Web Site: http://www.lunenfeld.ca/researchers/okamoto


Research:

Developing novel technologies to visualize and manipulate protein function in the brain


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  Osaka University, Japan
M.A.:  Toyama University, Japan
B.S.:  Toyama University, Japan


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

Elucidating the mechanisms of learning and memory is essential for understanding brain diseases such as Alzheimer’s disease and Autism. We aim to dissect the complex signaling cascades for learning & memory and related brain diseases by developing novel technologies to visualize and manipulate protein function in the brain.

 

Accepting Rotation Students:

Yes

 

Christopher Pearson

Christopher Pearson, Ph.D.

Professor

Address:
Hospital for Sick Children, Peter Gilgan Centre for Research & Learning, Rm. 14-9714, 
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-8256

Admin: Irina.Iovu@sickkids.ca

Web Site: http://www.cepearsonlab.com/


Research:

DNA repeat instability


Education:

Postdoctoral Fellow:  Texas Medical Center
Ph.D.:  McGill University
B.Sc. (Hon):  Concordia University


Fields of Interest:

  • Genetic Models of Development and Disease

  • Molecular Medicine and Human Genetics

 

Research Interests:

Understand DNA repeat instability; the cause of >40 diseases including Huntington's disease, muscular dystrophy & amyotrophic lateral sclerosis.
Use molecular, stem cell, transgenic mouse models and human tissues to understand and modulate this mutation for clinical benefit.
Focus on DNA repair, replication & epigenetics.
Identify therapeutic targets and preclinical therapeutic drugs.

 

Accepting Rotation Students:

Yes

 

Laurence Pelletier

Laurence Pelletier, Ph.D.

Professor

Address:
Mt. Sinai Hospital, LTRI, Room 1070
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 x6196

Web Site: http://pelletierlab.org


Research:

Centrosome biogenesis and function


Education:

Ph.D.:  Yale University
M.Sc.:  University of Montreal
B.Sc.:  University of Montreal


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

Our laboratory studies several facets of centrosome biogenesis and function, with a particular emphasis on how their perturbation can lead to genome instability, developmental diseases and cancer. Using functional genomic approaches and cutting-edge microscopy and biochemistry, our overarching goal is to identify and study novel proteins required centrosome and to investigate their potential role in development and diseases.

 

Accepting Rotation Students:

Yes

 

Stephanie Protze

Protze_Stephanie.jpg

Stephanie Protze, Ph.D.

Assistant Professor

Address:
McEwen Institute, University Health Network
PMCRT 3-918
101 College St.
Toronto, ON, M5G 1L7

Phone #: 416-634-8179

Web Site: https://www.uhnresearch.ca/researcher/stephanie-protze


Education:

Postdoctoral Fellowship:  McEwen Centre, University Health Network, Toronto
PhD: Dresden University of Technology, Germany
B.Sc: Dresden University of Technology, Germany


Fields of Interest:

  • Genetic Models of Development and Disease
  • Cellular and Molecular Structure and Function

 

Research Interests:

We are studying human heart development and disease using the human pluripotent stem cell model system. To facilitate that, my lab has specialized in developmental biology-based differentiation strategies. Our current research focuses on cardiac pacemaker cells and their application for in vitro disease modeling and cell therapies as biological pacemaker.

 

Accepting Rotation Students:

Yes

Miguel Ramalho-Santos

Miguel+in+Lab.jpg

Miguel Ramalho-Santos, Ph.D.

Associate Professor

Address:
Lunenfeld-Tannenbaum Research Institute
Room 6-1016-2
25 Orde St.
Toronto, ON, M5T 3H7

Phone #: 416-586-4800 x8377

Web Site: https://www.mrsantoslab.org


Education/Professional:

Faculty member:  University of California, San Francisco
Ph.D. & Postdoc:  Harvard University
M.Sc.: University of Coimbra, Portugal


Fields of Interest:

  • Genetic Models of Development & Disease
  • Cellular & Molecular Structure & Function

 

Research Interests:

Our lab is interested in understanding the epigenetic regulation of mammalian development and reproduction. Work from our lab highlights that such foundational aspects as genome organization, transcription and environmental input are regulated in unique ways in pluripotent stem cells of the early embryo and the germline.

 

Accepting Rotation Students:

Yes

James Rini

James Rini, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1614
Toronto, ON, M5G 1M1

Phone #: 416-978-0557
 


Research:

Using X-ray crystallography and biochemistry to study protein folding and coronavirus-host cell receptor interactions


Education

Postdoctoral Fellow:  Research Institute of Scripps Clinic, California
Ph.D.:  University of Toronto
B.Sc.:  University of Toronto


Fields of Interest

  • Cellular and Molecular Structure and Function
  • Molecular Microbiology and Infectious Disease

 

Research Interests

Our research is focused on the study of: i) ER-resident glycosyltransferases and their role in protein folding and quality control, and ii) coronavirus-host cell receptor interactions. In all cases we seek to determine structure-function relationships using x-ray crystallography and complementary biochemical and cell-based approaches.

 

Accepting Rotation Students:

No

 

Janet Rossant

Janet Rossant, Ph.D.

Professor

Address:
Hospital for Sick Children, PGCRL Rm. 16.9705
686 Bay St.
Toronto, ON, M5G 0A4

Phone #: 416-813-7929

Admin: katheline.aguilar@sickkids.ca

Web Site: http://lab.research.sickkids.ca/rossant/


Research:

Mechanisms of cell fate decisions in the early mouse embryo and embryo-derived stem cells


Education:

Postdoctoral Fellow:  Oxford University
Ph.D.:  Cambridge University
B.A. (Hon), M.A.:  Oxford University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Genetic Models of Development and Disease

 

Research Interests:

The Rossant lab is interested in mechanisms of cell fate decisions in the early mouse embryo and their application to the maintenance and differentiation of embryo-derived stem cells.

 

Accepting Rotation Students:

No

 

Ian Scott

Ian Scott, Ph.D.

Associate Professor

Address:

Hospital for Sick Children,
Peter Gilgan Centre for Research
& Learning, Rm. 16.9707
686 Bay St., Toronto,
ON, M5G 0A4

Phone #: 416 813-7654 ext 301572

Admin: katheline.aguilar@sickkids.ca

Web Sitehttp://www.sickkids.ca/AboutSickKids/Directory/People/S/Ian-C-Scott.html


Research:

Cardiovascular development and heart regeneration in zebrafish
 

Education:

Postdoctoral Fellow: University of California, San Francisco
Ph.D.:  University of Toronto
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

Research Interests:

Analysis of cardiovascular development and heart regeneration using the zebrafish model.  We are interested in uncovering the molecular and cellular events that govern embryonic heart development and adult heart regeneration, and applying these discoveries to methods to repair the damaged human heart.

 

Accepting Rotation Students:

Yes

 

Frank Sicheri

Frank Sicheri, Ph.D.

Professor

Address:
Mount Sinai Hospital,
LTRI Room 1090A,
600 University Ave,
Toronto, ON, M5G 1X5

Phone #: 416-586-8471

Web Sitehttp://research.lunenfeld.ca/sicheri/


Research:

Mechanisms of action of signaling molecules studied with X-ray crystallography and biochemical techniques
 

Education:

Postdoctoral Fellow:  Rockefeller University
Ph.D.:  McMaster University
B.Sc. (Hon):  McMaster University


Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Computational and Systems Biology

Research Interests:

Research in the Sicheri lab is focused on elucidating the mechanism of action of signalling molecules through the use of x-ray crystallography and biochemical techniques.

 

Accepting Rotation Students:

Yes

 

Sachdev Sidhu

Sachdev Sidhu, Ph.D.

Professor

Address:
University of Toronto,
The Donnelly Centre, Rm. 816
160 College St., Toronto, ON, M5S 3E1

Phone #: 416-946-0863

Web Sitehttp://sites.utoronto.ca/sidhulab/


Research:

Protein engineering to design synthetic antibodies to target and modulate protein-protein interactions

Education:

Postdoctoral Fellow:  Genentech Inc., California
Ph.D.:  Simon Fraser University
B.Sc. (Hon):  Simon Fraser University


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics
     

Research Interests:

My group uses protein engineering to design synthetic antibodies and other proteins to target and modulate the natural protein-protein interactions. We use these synthetic agents to investigate the roles of key protein-protein interactions in normal and diseased cellular states with the aim of developing novel therapuetics.

 

Accepting Rotation Students:

Yes

 

Andrew Spence

Andrew Spence, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1501
Toronto, ON, M5G 1M1

Phone #: 416-978-6406

Web Sitehttp://www.spencelab.ca


Research:

Determination of sex-specific cell fates in Caenorhabditis elegans via a novel form of epigenetic regulation
 

Education:

Postdoctoral Fellow:  MRC Laboratory of Molecular Biology, U.K.
Ph.D.:  University of British Columbia
B.Sc.:  University of Winnipeg
 

Fields of Interest:

  • Cellular and Molecular Structure and Function

  • Genetic Models of Development and Disease

Research Interests:

We study genes that determine sex-specific cell fates in Caenorhabditis elegans. We have described a novel form of epigenetic regulation that depends upon maternally contributed RNA to license gene expression in the germ line of the next generation, and we are using genetic and genomic approaches to understand its mechanism.

 

Accepting Rotation Students:

No

 

Igor Stagljar

Igor Stagljar, Ph.D.

Professor

Address:
University of Toronto,
Donnelly Centre, Rm. 1204
160 College St., Toronto, ON M5S 3E1

Phone #: 416-946-7828

Web Sitehttp://biochemistry.utoronto.ca/stagljar/


Research:

Studies of yeast and human integral membrane proteins in cell signaling and membrane transport at a system level

Education:

Postdoctoral Fellow:  University of Zurich & University of Washington (Seattle)
Ph.D.:  Swiss Federal Institute of Technology (ETH) Zurich, Switzerland
B.Sc.:  University of Zagreb, Croatia
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics
     

Research Interests:

A focus of my lab is to understand the function of the majority of “druggable” yeast and human integral membrane proteins involved in cell signaling and membrane transport at a systems level. Despite extensive research in the past decade, there is a lack of in-depth understanding of protein networks associated with these integral membrane proteins because of their unique biochemical features, enormous complexity and multiplicity. This is a major obstacle for designing improved and more targeted therapies, and importantly, understanding the biology of deregulation of these integral membrane proteins which leads to numerous human diseases.  To address this challenge, we are applying an in vivo genetic system previously developed in my lab, called the membrane yeast two-hybrid (MYTH) assay, to identify and characterize protein interactors of all yeast ABC transporters and human receptor tyrosine kinases (RTKs), as well as selected cancer stem cell receptors (CSCRs) and G-protein coupled receptors (GPCRs).  In   the past years, we have shown that the newly identified interactors of these various integral membrane proteins play novel roles in regulating their activity both in vivo and in vitro. In this way, our systematic MYTH approach offers an unbiased systems level view that facilitates the identification of novel drug targets, thereby promising significant contributions to therapeutic research.

 

Boris Steipe

Boris Steipe, M.D., Ph.D.

Associate Professor

Address:
University of Toronto,
Medical Sciences Building, Rm. 5271
1 King's College Circle,
Toronto, ON M5S 1A8

Phone #: 416-946-7741

Web Sitehttp://biochemistry.utoronto.ca/steipe/


Research:

Patterns in molecular structure: computational methods of pattern discovery
 

Education:

Postdoctoral Fellow: Max-Planck-Institute for Biochemistry, Germany
Ph.D., M.D.:  University of Munich, Germany
 

Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Computational and Systems Biology
     

Research Interests:

I am interested in recurring patterns in molecular structure: the computational methods of pattern discovery, their characterization regarding features, context and distribution,  their association with function in proteins, and their utility for protein engineering and design.

 

Accepting Rotation Students:

No