Speaker: Dr. Swathi Arur
Affiliation: The University of Texas MD Anderson Cancer Center
Host: Dr. Julie Claycomb
Date & Time: October 26th - 4PM
Place: FitzGerald Building, Room 103

Cellular and molecular mechanisms that suppress small RNAs in oocytes while maintaining them in zygotes remain unknown. Signal-mediated regulation of small RNA biogenesis pathway is emerging as a theme for regulating small RNA production. We recently reported that ERK-mediated phosphorylation of Dicer, a central player in small RNA biogenesis, induced Dicer to move from the cytoplasm to the nucleus, and critical for the process of oocyte to embryo transition in worms.  Strikingly, signal-induced Dicer translocation from the cytoplasm to nucleus is evolutionarily conserved from worm, flies, mice to humans thereby suggesting the ERK-mediated control of Dicer activity may be a generalized mechanism for regulating small RNA biogenesis.

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