Dr. Allan Drummond
University of Chicago
Host: Dr. Mikko Taipale
Rethinking stress-triggered aggregation
Monday October 2 @ 4PM
Fitzgerald Building, Room 103, 150 College Street
Many cellular stresses cause proteins to aggregate. Although aggregation has long been thought to result from stress-induced misfolding, forming toxic clumps in need of cleanup, recent work supports an alternative interpretation: stress-triggered formation of adaptive molecular assemblies with adaptive roles. I will discuss our work on the adaptive stress-triggered phase separation of a major eukaryotic RNA-binding protein.