Dr. Helen Mcneill

Dr. Helen Mcneill

 MoGen team led by Helen McNeill discovered that the large cell-surface cadherin Fat, known for its role in the regulation of planar cell polarity and the Hippo pathway, is also essential for normal oxidative phosphorylation. Fat is proteolytically processed to release an intracellular fragment, which is targeted to mitochondria, where it interacts with components of the electron transport chain. Loss of Fat leads to increases in reactive oxygen species and a switch to aerobic glycolysis, and is reminiscent of the Warburg effect.

Cell 2014, 158;1293-208