Dr. Brian Ciruna

Dr. Brian Ciruna

The team led by Brian Ciruna pioneered a zygotic ptk7 zebrafish model of AIS, deficient in a key regulator of Wnt signalling. They identify genetic links between congenital and idiopathic forms of scoliosis and implicate dysregulated Wnt signaling in AIS, which manifests as a late onset spinal deformity that occurs in 3% of schoolchildren worldwide.  Photo credit: Madeline Hayes and Matthijs van Eede.
 

Nature Communications 2014, 5:477