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(Cell 2014 158:434-48). An international team led by MoGen scientists Mikko Taipale and Anne-Claude Gingras, and Whitehead scientist Susan Lindquist, systematically investigated protein-protein interactions of key chaperones required for modulating the folding and function of target proteins. They identified a complex landscape of interactions for Hsp90 and its co-chaperones, with  implications for understanding cancer and neurodegenerative disease.