Study uncovers a novel mechanism controlling DNA repair in mammalian cells (Molecular Cell 2016, 61: 405-18). Team led by Dr. Daniel Durocher uncovered a mechanism that controls how double-strand breaks in DNA are repaired. They discovered that a protein that unwinds DNA, a DNA helicase called HELB, is able to halt the process of chewing back DNA to create single-stranded overhangs that are needed to initiate repair via homologous recombination. This work has broad implications for understanding maintenance of genome integrity, and how this goes awry in cancer.

Dr. Daniel Durocher

Dr. Daniel Durocher