This course is intended to rapidly familiarize QBMG/CBMG students (and others) with central themes in Molecular Genetics and in topics germane to quantitative and computational biology. It is held at the beginning of the fall term in order to facilitate rotation choices.

Each speaker is in charge of a 2-hour session consisting of a presentation/discussion. The first hour is a general introduction to their field.  The second hour is an overview of some key questions in the field, and a description of their own research goals. Each session comes with an assigned paper to read.  Each lecture (except the first) will end with a five-point quiz on the reading and the lecture. The mark is determined 50% from the quiz scores and 50% from the final exam.

  1. September 12 (Mon):  Introduction, microarrays and sequencing technologies (DNA, RNA, protein); gene expression applications (Tim Hughes)
  2. September 15 (Thurs):  Genetics, genetic screens and drug screens (Peter Roy)
  3. September 19 (Mon):  Yeast genetics and genomics (Charlie Boone)
  4. September 26 (Mon):  Screening, RNAi, CRISPR, and image processing (Jason Moffat)
  5. September 29 (Thurs):  Next-gen sequencing analysis and applications: barcoding, mutagenesis, interaction screens (Fritz Roth)
  6. October 3 (Mon):  Regenerative medicine and stem cells (Derek van der Kooy)
  7. October 6 (Thurs):  Metabolomics and data analysis (Amy Caudy)
  8. October 13 (Thurs):  Biological network and pathway analysis (Gary Bader)
  9. October 17 (Mon):  Comparative genomics, variation, and noncoding RNA (Zhaolei Zhang)
  10. October 20 (Thurs):  RNA structure and post-transcriptional gene regulation (Quaid Morris)
  11. October 24 (Mon):  Physical interaction assays for proteins, RNA and DNA in cells, including mass spectrometry (Anne-Claude Gingras)
  12. November 3 (Mon):  Exam. Students will write a six-page grant proposal (single-spaced), due October 31, on a topic of their choosing (related to the course) that incorporates techniques from at least two of the lectures, and present it to the class on October 31. 

Note: This is a two-credit QBMG/CBMG graduate topic course

Coordinator: Dr. Tim Hughes

Date: Mondays & Thursdays, September 12 - November 3 (see class schedule in description above)

Time: 10:00 a.m. - 12:00 p.m.

Place: MSB 2290