This course will study the progression from basic science to the development and application of new therapeutics, with a focus on cancer therapy. The course will present two case studies, one a biologic protein therapeutic and the other a small-molecule drug. For each case study, we will review (1) the basic biology behind a cancer-associated signaling pathway, (2) the rationale and strategy for developing inhibitors of the pathway, and (3) the application of these inhibitors for human therapy. Students will participate in journal-club style reviews and will primarily be graded on a written research proposal.

Coordinators: Dr. Peter Dirks and Dr. Sachdev Sidhu
Dates: September - October, 2019
Time: TBA
Place: TBA
Enrollment: Class size is limited to 15 students