This course will study the progression from basic science to the development and application of new therapeutics, with a focus on cancer therapy. The course will present two case studies, one a biologic protein therapeutic and the other a small-molecule drug. For each case study, we will review (1) the basic biology behind a cancer-associated signaling pathway, (2) the rationale and strategy for developing inhibitors of the pathway, and (3) the application of these inhibitors for human therapy. Students will participate in journal-club style reviews and will primarily be graded on a written research proposal.

Coordinators: Dr. Peter Dirks and Dr. Sachdev Sidhu
Dates: October 19, Wednesdays, Nov. 1 - 15, Nov 23 (2 sessions) Dec. 7 or 14
Time: 9AM - 11AM
Place: Oct. 19: MSB2394; Nov. 1, 8, 15: MSB4174; Nov 29 (2 sessions): 9AM - 1PM: MSB4174, Dec. 7 OR 14: MSB4174
Enrollment: Class size is limited to 15 students