This course will focus on recent advances in cancer molecular genetics and application to human disease. Specifically we will address genetic factors with respect to cancer susceptibility (tumor suppressor and DNA repair genes), tumor-specific genomics and gene expression (tumor suppressor genes and oncogenes), and therapies targeting this knowledge. Within each area, clinical application and relevance will be emphasized. Scientific tools that enable this research will be addressed, such as statistical genetics, expression profiling, genomic screens, and siRNA approaches to targeted therapies. The course will consist of lectures and presentations and discussion by students of selected publications. The course grade will be based on presentations, participation in discussions and a short written paper.