This course will examine the mechanics of cell division and how the cell cycle is governed by internal and external regulatory cues. Specific subjects will include coupling between growth and division, cell cycle commitment, the initiation of DNA replication, chromosome dynamics, mitotic entry and exit, checkpoint signals, developmental control of division and cell cycle aberrations in cancer. General concepts including decision points, feedback loops, ultrasensitivity, stochasticity, noise suppression and mathematical modeling will be emphasized throughout the course. Landmark publications in a variety of model organism systems will be presented and discussed by students. The course grade will be based on presentations, participation in discussions and an operating grant-style research proposal.