This course will cover topics related to the mechanisms underlying post-transcriptional control of gene expression in eukaryotes. Students will be organized into 6 groups. Each group will be assigned a topic, develop a 60 min power point-assisted lecture that would be suitable to teach this topic to a class of first year graduate students, and present the lecture to the class. The 6 topics will be:
- RNA/protein interactions
- mRNA splicing,
- mRNA export
- mRNA localization
- translational regulation, and
- control of mRNA stability
Each group should consult with Drs. Smibert and Cochrane regarding the content of each topic lecture.
Each class will begin with a student-led lecture, which will be followed by a discussion of one or two papers related to the lecture and then will end with a ~15 minute presentation by a second group outlining future experiments building on the findings of the presented papers. Note that the lecture should be developed with the content of the discussion paper in mind.
Enrollment: 8-24 students