Regulation of Gene Expression

The participants in this course will discuss selected topics dealing mainly with regulatory mechanisms that control gene expression by RNA polymerase II in eukaryotes.  Topics will include: assembly of the initiation complex; roles of transcription factors, co-activators and cis-acting regulatory elements; promoter escape; mechanisms that control elongation and termination of transcription; chromatin control of transcription; regulatory RNAs; and chromosome conformation.  The course will be structured so as to have an introductory lecture on a specific topic in one class followed by the next class being a participatory discussion of pre-assigned research papers in which all students will have prepared themselves to present any of the individual figures from the assigned papers.

Exclusions: BIO477H5 (UTM)

Prerequisites: MGY311Y1/MGB311Y1/BCH311Y1

Course Coordinator: Dr. Jack Greenblatt

Offered: September to December 2019 - Mondays and Wednesdays 11:00 a.m. to 1:00 p.m. (11:00 am for lectures; 11:00 am or 12:00 noon for discussions)

Location: HS 108