Regulation of Gene Expression

The participants in this course will discuss selected topics dealing mainly with regulatory mechanisms that control gene expression by RNA polymerase II in eukaryotes.  Topics will include: assembly of the initiation complex; roles of transcription factors, co-activators and cis-acting regulatory elements; promoter escape; mechanisms that control elongation, termination and anti-termination of transcription; chromatin control of transcription.  The course will be structured so as to have an introductory lecture on a specific topic in one class followed by the next class being a participatory discussion of pre-assigned research papers in which all students will have prepared themselves to present any of the individual figures from the assigned papers.

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Prerequisite: MGY311Y1 / MGB311Y1

Exclusion: BIO477H5 (UTM)

Course Coordinator: Dr. Marc Meneghini

Offered: September to December 2016 - Mondays and Wednesdays (11:00 a.m. to 1:00 p.m.)

Location: Medical Sciences Building, Room 4171