Viewing entries in
Genomics & Proteomics

Brenda Andrews

Brenda Andrews, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1308
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-8562

Web Site: http://sites.utoronto.ca/andrewslab/homepage.html


Research:

Studying simple yeast cells to understand human cells


Education:

Postdoctoral Fellow: University of California, San Francisco
Ph.D.: University of Toronto
B.Sc.: University of Toronto


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

The Andrews lab uses functional genomics coupled with yeast genetics and cell biology to study cell cycle transcription factor pathways and mechanisms of cell cycle regulation. Current projects include: 1) systematic synthetic dosage lethality (SDL) screens using automated yeast genetics to define targets of protein kinases; 2) a 'phenomics' project that uses high through put fluorescence microscopy to define biological networks and to map cell cycle transcription factor pathways; 3) collaborations with the Boone, Hughes and other labs to map genetic networks controlling cell cycle progression and cell polarity in yeast.

 

Accepting Rotation Students:

Yes

 

 

 

 

Gary Bader

Gary Bader, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 602
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-3935

Web Site: http://baderlab.org/


Research:

Organization and evolution of biological systems


Education:

Postdoctoral Fellow:  Memorial Sloan-Kettering Cancer Center
Ph.D.: University of Toronto  
B.Sc.: McGill University


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

We study the organization and evolution of biological systems using computational biology and bioinformatics techniques. This work is supported through the development of open-source biological pathway and network databases and visualization and analysis software.

 

Accepting Rotation Students:

No

 

Benjamin Blencowe

Benjamin Blencowe, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1016
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-3016

Web Site: http://sites.utoronto.ca/intron/


Research:

Regulation of gene expression and alternative splicing


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  EMBL, Heidelberg, Germany and University of London, UK
B.Sc (Hon):  Imperial College London, UK


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

Our research focuses on mechanisms underlying the regulation of gene expression and how these mechanisms go awry in human diseases. Most of our research is directed at understanding how alternative splicing is integrated with other layers of gene regulation to control fundamental biological processes, such as cell fate determination.

 

Accepting Rotation Students:

Yes

 

 

Charles Boone

Charles Boone, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Room 1312
160 College Street
Toronto, ON M5S 3E1

Phone #: 416-946-7260

Web Site: http://sites.utoronto.ca/boonelab/


Research:

Functional genomics for mapping genetic, chemical-genetic, and protein-protein interactions in yeast


Education:

Postdoctoral Fellow:  University of Oregon
Ph.D.:  McGill University
B.Sc.:  Queen's University


Fields of Interest:

Computational and Systems Biology
Functional Genomics and Proteomics

 

Research Interests:

We are developing and applying functional genomics approaches for mapping genetic, chemical-genetic, and protein-protein interactions on a large-scale using the yeast model system. The ultimate goal is to place all yeast genes and their corresponding products on a functional network.

 

Accepting Rotation Students:

Yes

 

 

 

Richard Collins

Richard Collins, Ph.D.

Professor

Address:
University of Toronto
Medical Sciences Building, Rm. 4280
1 King's College Circle
Toronto, ON, M5S 1A8

Phone #: 416-978-3541

Web Site: http://individual.utoronto.ca/collins_lab/


Research:

RNA and mitochondria


Education:

Postdoctoral Fellow:  St. Louis University
Ph.D.:  University of Regina
B.Sc.:  University of Regina


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

 We are interested in RNA and mitochondria, especially a natually-occurring Neurospora mitochondrial plasmid that encodes a catalytic RNA called the VS ribozyme. We are currently studying how such plasmids move between mitochondria, and whether they may be useful as vectors for genetic transformation of mitochondria.

 

Leah Cowen

Leah Cowen, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1638
Toronto, ON, M5G 1M1

Phone # :416-978-4085

Web Site: http://individual.utoronto.ca/cowen/index.html


Research:

Pathogenic fungi in evolution, development, and disease


Education:

Postdoctoral Fellow:  Massachusetts Institute of Technology
Ph.D.:  University of Toronto
B.Sc.:  University of British Columbia


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

Research in the Cowen lab exploits model and pathogenic fungi to address mechanisms governing evolution, development, drug resistance, and infectious disease.  We take an interdisciplinary approach incorporating genomics, proteomics, chemical genomics, molecular genetics, experimental evolution, and models of fungal pathogenesis.  Our work reveals novel therapeutic strategies for life-threatening infectious disease.

 

Accepting Rotation Students:

Yes

 

 

Brent Derry

Brent Derry, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm 18-9714
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-7654 ext. 301829

Admin: taylor.becker@sickkids.ca

Web Site: http://lab.research.sickkids.ca/derry


Research:

Apoptosis and DNA repair in C. elegans


Education:

Postdoctoral Fellow:  University of California, Santa Barbara
Ph.D.: University of California, Santa Barbara
M.Sc.:  Carleton University
B.Sc.:  McMaster University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We are interested in cell autonomous and cell-nonautonomous mechanisms of apoptosis and DNA repair in the nematode worm C. elegans. We are also interested in understanding mechanisms by which the cerebral cavernous malformation (CCM) proteins control excretory canal development.

 

Accepting Rotation Students:

Yes

 

Daniel Durocher

Daniel Durocher, Ph.D.

Professor

Address:
Mt. Sinai Hospital
LTRI, Rm.1073
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-4800 ext 2544

Web Site: http://research.lunenfeld.ca/durocher


Research:

Molecular basis of genome integrity


Education:

Postdoctoral Fellow: University of Cambridge
Ph.D. McGill University
B.Sc. Université de Montréal


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

I am interested in understanding the molecular basis of genome integrity. Our research is ultimately relevant to cancer, aging, evolution and stem cell biology.

 

Accepting Rotation Students:

Yes

 

Aled Edwards

Aled Edwards, Ph.D.

Professor

Address:
Structural Genome Consortium
MaRS South Tower Rm. 701 
101 College St.
Toronto, ON, M5G 1L5

Phone #:416-946-3795

Web Site: http://www.thesgc.org/about/director


Research:

Developing open access research tools (chemical inhibitors, protein structures and recombinant antibodies)
Additional Affiliations
Structural Genomics Consortium

*currently on leave from Dept. of Molecular Genetics while serving as Director of SGC


Education:

Postdoctoral Fellow: Stanford University
Ph.D.: McGill University
B.Sc.: McGill University


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Medicine and Human Genetics

Research Interests:

Developing open access research tools (chemical inhibitors, protein structures and recombinant antibodies) to increase knowledge of human biology and accelerate drug discovery

 

Sean Egan

Egan.jpg

Sean Egan, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 15-9704
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 416-813-5267

Admin: iris.biberstein@sickkids.ca

Web Site: http://www.sickkids.ca/.../Sean-Egan.html


Research:

Mouse models of breast cancer and development


Education:

Postdoctoral Fellow:  The Whitehead Institute/Massachusetts Institute of Technology
Ph.D.:  University of Manitoba, Department of Microbiology
B.Sc. (Hon): University of Manitoba


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

Research Interests:

The Egan lab uses mouse models to study breast cancer and mouse development. For example, we use gene targeting to design models for breast cancer which can be probed to define cooperative signaling networks that are involved in transformation and metastasis, and that can be targeted in the clinic.

 

Andrew Emili

Andrew Emili, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre Rm. 904
160 College St.,
Toronto, ON, M5S 3E1

Phone #: 416-946-7281

Web Site: http://sites.utoronto.ca/emililab/


Research:

Systems-level analysis of complex molecular networks


Education:

Postdoctoral Fellow:  Fred Hutchinson Cancer Center, Seattle, WA
Ph.D., M.Sc.: University of Toronto
B.Sc.: McGill University


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

Research Interests:

Systems-level analysis of the complex molecular networks that underly basic cell biology, with an emphasis on developing and applying innovative methods and technologies to investigate diverse model organisms.

 

Alex Ensminger

Alex Ensminger, Ph.D.

Associate Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1637
Toronto, ON, M5G 1M1

Phone #: 416-978-6522

Web Site: http://individual.utoronto.ca/ensminger_lab/


Research:

Host-pathogen interactions and clinical microevolution of Legionella pneumophila


Education:

Postdoctoral Fellow: Tufts University School of Medicine
Ph.D.: Massachusetts Institute of Technology
B.Sc.: Haverford College


Fields of Interest:

  • Functional Genomics and Proteomics
  • Molecular Microbiology and Infectious Disease

 

Research Interests:

We use cutting-edge genomics, experimental evolution, and high-throughput robotics to study host-pathogen interactions and clinical microevolution. Our work is primarily focused on the causative agent of Legionnaires’ Disease, Legionella pneumophila, an often-fatal intracellular bacterial pathogen with a remarkably broad host range.

 

Accepting Rotation Students:

No

 

Andrew Fraser

Andrew Fraser, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre
Rm. 1212, 160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-2712

Web Site: http://www.fraserlab.org/


Research:

How variations in genome sequence affect phenotype in C. elegans


Education:

Postdoctoral Fellow: Wellcome/CRC Institute, U.K.
Postdoctoral Fellow: Cold Spring Harbor
Ph.D.:  University of London, U.K.
B.Sc. - University of Cambridge, U.K.


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We want to understand how variations in genome sequence affect phenotype in health and disease. To do this, we use the nematode worm as a simple model system in which we can perturb the function of any gene in any genetic background and learn how to predict the outcome.

 

Accepting Rotation Students:

No

 

Anne-Claude Gingras

Anne-Claude Gingras, Ph.D.

Professor

Address:
Mount Sinai Hospital
LTRI, Rm. 992
600 University Ave.
Toronto, ON, M5G 1X5

Phone #: 416-586-5027

Web Site: http://gingraslab.lunenfeld.ca/


Research:

Proteomics, biochemistry cell biology phosphoregulation


Education:

Postdoctoral Fellow:  Institute for Systems Biology, Seattle
Ph.D.:  McGill University
B.Sc.:  Université Laval, Ste-Foy


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases whose misregulation may result in numerous diseases, including cancer, diabetes and vascular diseases. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to uncover the basis of phosphoregulation.

 

Accepting Rotation Students:

No

 

Timothy Hughes

Hughes.jpg

Timothy Hughes, Ph.D.


Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 1302
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-946-8260

Web Site: http://hugheslab.med.utoronto.ca/


Research:

How eukarotic cells recognize and interpret the information in the genome, by studying protein-DNA and protein-RNA sequence specificity


Education:

Postdoctoral Fellow:  Rosetta Inpharmatics (now Merck)
Ph.D.:  Baylor College of Medicine
B.Sc., B. Music:  University of Iowa


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

The genome sequence has been described as a blueprint, but it is one that we are largely unable to read.  Our goal is to understand how eukaryotic cells recognize and interpret the information in the genome, by collecting large-scale data on protein-DNA and protein-RNA sequence specificity.

 

Accepting Rotation Students:

Yes

 

Philip Kim

Kim.jpg

Philip Kim, Ph.D.

Associate Professor

Address:
University of Toronto
The Donnelly Centre Rm. 606
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-946-3419

Web Site: http://www.kimlab.org/


Research:

Computational methods to study protein interactions and signaling networks in the context of cancer and other diseases


Education:

Postdoctoral Fellow: Yale University
Ph.D.:  Massachusetts Institute of Technology
Vordiplom/B.S.:  University of Tuebingen


Fields of Interest:

  • Computational and Systems Biology
  • Functional Genomics and Proteomics

 

Research Interests:

The Kim lab uses and develops computational methods to study protein interactions and signaling networks in the context of cancer and other diseases. We use an integrative approach that encompass structural biophysics, systems biology and comparative genomics. Ultimately, we aim to help develop novel therapies.

 

Accepting Rotation Students:

Yes

 

Henry Krause

Henry Krause, Ph.D.

Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 502
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-8602

Web Site: http://sites.utoronto.ca/krause


Research:

Drosophila and Zebrafish genome-scale approaches to understanding development and disease


Education:

Postdoctoral Fellow:  Biozentrum, Switzerland
Ph.D.: University of Alabama, Birmingham
B.Sc.: McGill University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

Our lab is using live animal (Drosophila and zebrafish), genome-scale approaches to understand developmental and disease processes. We have also developed animal models to screen for new drugs that control diseases such as diabetes, cancer and depression.

 

Accepting Rotation Students:

No

 

Howard Lipshitz

Howard Lipshitz, Ph.D.

Professor

Address:
MaRS Centre, West Tower
661 University Ave., Rm. 1538
Toronto, ON M5G 1M1

Phone #: 416-946-5296

Web Site: http://sites.utoronto.ca/flylab


Research:

Post-transcriptional regulation of gene expression in Drosophila with a focus on RNA-binding proteins and small RNAs


Education:

Postdoctoral Fellow:  Stanford University
M.Phil., Ph.D.:  Yale University
B.Sc., B.Sc.(Hon):  University of Natal, Durban, South Africa 


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

We study post-transcriptional regulation of gene expression in Drosophila with a focus on RNA-binding proteins and small RNAs that regulate the stability, subcellular localization and translation of maternal mRNAs in early embryos. We use gene-by-gene and genome-wide analyses of the transcriptome, ribonome and proteome.

 

Accepting Rotation Students:

Yes

 

Jason Moffat

Jason Moffat, Ph.D.

Associate Professor

Address:
University of Toronto
The Donnelly Centre, Rm. 802
160 College St.
Toronto, ON, M5S 3E1

Phone #: 416-978-0336

Web Site: http://moffatlab.ccbr.utoronto.ca/


Research:

Genetic interaction networks in cancer cells.


Education:

Postdoctal Fellow:  Massachusetts Institute of Technology
Ph.D.:  University of Toronto
B.Sc. (Hon):  Queen's University


Fields of Interest:

  • Genetic Models of Development and Disease
  • Functional Genomics and Proteomics

 

Research Interests:

The Moffat lab is interested in cancer and genetic interaction networks in cancer cells.

 

Accepting Rotation Students:

Yes

 

Michael Moran

Moran.jpg

Michael Moran, Ph.D.

Professor

Address:
Hospital for Sick Children
Peter Gilgan Centre for Research & Learning, Rm. 17-9705
686 Bay St.
Toronto, ON M5G 0A4

Phone #: 647-235-6435

Web Site: http://www.sickkids.ca/.../Moran%20.html


Research:

Proteomics and functional genomics to define and stratify cancers focused on signal transduction and metabolic networks


Education:

Postdoctoral Fellow:  Mt. Sinai Hospital, Toronto
Ph.D.:  University of Western Ontario
B.Sc.:  University of Western Ontario


Fields of Interest:

  • Cellular and Molecular Structure and Function
  • Functional Genomics and Proteomics

 

Research Interests:

Proteomics and functional genomics datasets are integrated in order to define and stratify cancers according to their distinctive molecular signatures. Underlying signal transduction and metabolic networks, and their regulation by post-translational modifications, are then molecularly characterized for their contributions to cancer phenotypes.

 

Accepting Rotation Students:

Yes